A5041459325- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Bioactive Compounds and Antitumor Agents
- Synthesis and biological activity
- Synthesis and Biological Evaluation
- Cancer therapeutics and mechanisms
- Synthesis and Characterization of Heterocyclic Compounds
- Click Chemistry and Applications
- Multicomponent Synthesis of Heterocycles
- Quinazolinone synthesis and applications
- Tuberculosis Research and Epidemiology
- Crystallography and molecular interactions
- Porphyrin and Phthalocyanine Chemistry
- Carbohydrate Chemistry and Synthesis
- Concrete Corrosion and Durability
- Enzyme Catalysis and Immobilization
- Sesquiterpenes and Asteraceae Studies
- Cyclopropane Reaction Mechanisms
- Free Radicals and Antioxidants
- Pneumocystis jirovecii pneumonia detection and treatment
- Natural product bioactivities and synthesis
- Venomous Animal Envenomation and Studies
- Rabies epidemiology and control
- Biological Activity of Diterpenoids and Biflavonoids
- Chronic Myeloid Leukemia Treatments
Universidade Federal de Sergipe
2025
Universidade Federal Fluminense
2015-2024
Hospital Israelita Albert Einstein
2022-2024
Rede de Química e Tecnologia
2022
Hospital Municipal São José
2022
Fundação Oswaldo Cruz
2021
Discovery Air (Canada)
2020
Brazilian National Association of Graduate Programs in Communication
2015-2017
University of Aveiro
2017
Universidade Federal do Rio de Janeiro
2017
Tuberculosis treatment remains a challenge that requires new antitubercular agents due to the emergence of multidrug-resistant Mycobacterium strains. This paper describes synthesis, activity and theoretical analysis N-substituted-phenylamino-5-methyl-1H-1,2,3-triazole-4-carbohydrazides (8a–b, 8e–f, 8i–j 8n–o) analogues (8c–d, 8g–h, 8l–m 8p–q). These derivatives were synthesized in good yields some them showed promising profile. Interestingly N-acylhydrazone (NAH) 8n was most potent against...
Genetically improved farmed tilapia (GIFT) is a strain of Nile ( Oreochromis niloticus ) developed for production and commercial parameters. Skin color, one the characteristics distinguishing varieties, an important phenotypic trait associated with qualitative productive performance. This study aimed to assess fillet skin in GIFT black red phenotypes. For this, 24 from same spawning stock were divided into two groups based on namely variety (dark skin) (reddish skin). There no significant...
The current treatment used against envenomation by Lachesis muta venom still presents several side effects. This paper describes the synthesis, pharmacological and theoretical evaluations of new 1-arylsulfonylamino-5-methyl-1H-[1,2,3]-triazole-4-carboxylic acid ethyl esters (8a–f) tested hemolytic profile L. snake venom. Their structures were elucidated one- two-dimensional NMR techniques (1H, APT, HETCOR 1JCH nJCH, n = 2, 3) high-resolution electrospray ionization mass spectrometry. series...
In this work we described the synthesis and antimicrobial evaluation of 7-arylamino-5,8-dioxo-5,8-dihydroisoquinoline-4-carboxylates derivatives that exhibited remarkable activity against two Gram-negative strains clinical importance.
This review discusses the development and applications of bioconjugates derived from natural hydroxycinnamic acids (HCA), such as coumaric, sinapic, ferulic, caffeic acids, combined with various biomaterials. These offer a range benefits including antioxidant properties, UV protection, customized hydrophilic–lipophilic balance, improved safety, solubility, emolliency, biocompatibility, biodegradability, targeted delivery for biomedical, cosmetic, food applications. The increasing demand...
A novel series of carbohydrate-based 1,2-naphthoquinones 13a–c and their substituted phenylhydrazono derivatives 14a–l were synthesized evaluated for cytotoxicity against HL-60, MDA-MB435, HCT-116 SF-295 cancer cell lines. The compounds 9a–c showed the best profile (IC50 below 2 μM) HL-60 MDA-MB 435 human cells, while hydrazone derivative 14i 1.65 was selective leukemia when compared to reference drug doxorubicin. None exhibited lytic effects mouse erythrocytes. Characterization all...
A novel series of carbohydrate-based naphthoquinones was synthesized and evaluated for cytotoxicity against different human cancer cell lines (HCT-116, A-549 MDA-MB 435). The compounds derived from juglone showed better profiles.
In this work a microwave-assisted Knoevenagel/Michael/cyclization multicomponent domino methodology, using ethanol as solvent and the ionic liquid 1-methylimidazolium chloride catalyst was developed for synthesis of spiro compounds. The reaction conditions considered ideal were determined from methodological study varying solvent, catalyst, amount temperature, heating mode. Finally, generality methodology evaluated by exploring scope reaction, starting materials (isatin, malononitrile,...
Starting from 2-hydroxy-1,4-naphthoquinone (lawsone), we synthesized eight new 6H-dibenzo[b,h]xanthene derivatives selectively under solvent-free conditions. Spectroscopic investigations confirmed that only the isomer was obtained in all cases. Computational studies provide a rationalization for selective appearance of these isomers having as an intermediate addition product.
(1) Background: The pandemic led to significant healthcare disruptions, resulting in postponed surgeries and extended waiting times for non-urgent treatments, including hysteroscopies essential diagnosing endometrial cancer. This study aims formulate a risk stratification model enhance the prioritization of hysteroscopy procedures Brazil; (2) Methods: A case-control was conducted at Vila Santa Catarina Hospital São Paulo, analyzing medical records 2103 women who underwent between March 2019...
Natural alkylated hydroxy cinnamates (AHCs) isolated from medicinal plants and the thereby designed synthesized cinnamides are derivatives of cinnamic acids such as p-coumaric, sinapic, ferulic, caffeic acids, which naturally derived human dietary sources. The pharmacological properties displayed by AHCs based on their inherent structure range include antioxidant, antimicrobial, antiplasmodial, anti-tyrosinase, Alzheimer’s Parkinson’s disease therapy, anticancer metabolic biopesticides, have...
A new and efficient method for the synthesis of hexahydropyrimidine-fused 1,4-naphthoquinones in one step with high yields from reaction lawsone 1,3,5-triazinanes was developed.
This work describes the first determination of absolute configuration (AC) (-)-cubebin by means electronic circular dichroism (ECD), supported quantum chemical calculations.The comparison experimental ECD with corresponding prediction for proper diastereoisomer resulted in definitive assignment AC naturally occurring as (8R,8aR,9S).The challenging relative (RC) cubebin based only on nuclear magnetic resonance (NMR) methods is stressed.Computation 13 C and 1 H NMR shifts all possible...