A5059202858- Ocular Diseases and Behçet’s Syndrome
- Systemic Lupus Erythematosus Research
- Psoriasis: Treatment and Pathogenesis
- RNA modifications and cancer
- Endoplasmic Reticulum Stress and Disease
- Gastric Cancer Management and Outcomes
- Neonatal Respiratory Health Research
- Mitochondrial Function and Pathology
- Multiple and Secondary Primary Cancers
- Liver Disease Diagnosis and Treatment
- Retinal and Optic Conditions
- Olfactory and Sensory Function Studies
- Radiomics and Machine Learning in Medical Imaging
- Advanced Chemical Sensor Technologies
- Air Quality and Health Impacts
- Galectins and Cancer Biology
- Helicobacter pylori-related gastroenterology studies
- Ubiquitin and proteasome pathways
- Immunodeficiency and Autoimmune Disorders
- Lung Cancer Treatments and Mutations
- interferon and immune responses
- Hepatitis B Virus Studies
- Cancer-related gene regulation
- Vitamin D Research Studies
- Immune Cell Function and Interaction
Shanghai Changzheng Hospital
2024-2025
Xian Center for Disease Control and Prevention
2024
Second Military Medical University
2024
Sun Yat-sen University
2017-2023
University of Science and Technology of China
2021
Anhui Medical University
2021
Aberrant expression of programmed death ligand-1 (PD-L1) facilitates tumor immune evasion. Protein arginine methyltransferase 3 (PRMT3), a member type I PRMT family, mediates asymmetric dimethylarginine (ADMA) modification various substrate proteins. This study investigates the role PRMT3 in PD-L1-associated immunosuppression hepatocellular carcinoma (HCC). Hepatocyte-specific knockout Prmt3 significantly suppressed HCC progression DEN-CCL4-treated mice. Knockout cells markedly increased...
Highlights•Active disease in uveitis patients is associated with reduced serum IFN-α•Effective treatment of type I IFN requires CXCR3 signaling•CXCR3 engagement retains pathogenic CD4+ T cells peripheral lymphoid organs•CXCR3 may be a potential biomarker to predict the efficacy for therapySummaryType interferons (IFNs) have therapeutic CNS autoimmune diseases, such as uveitis, but molecular mechanisms remain unclear. Using cell-transfer model experimental (EAU), we found that IFN-α/β...
Objective To explore the relationships between gastric cancer and serum pepsinogen I (PG I), PG II, I/II ratio, gastrin 17 (G-17) Helicobacter pylori infection, to investigate dietary lifestyle risk factors for in Fujian Province, China. Design A hospital-based, 1:1 matched case–control study. Setting Patients with newly diagnosed were recruited from Provincial Hospital No. 900 of Joint Support Force Chinese People’s Liberation Army July 2014 December 2016. Participants total 180 pairs...
Human uveitis is an autoimmune disease of the central nervous system that characterized by ocular inflammation with involvement uveitogenic Th1 and Th17 responses. In experimental (EAU), animal model for human uveitis, both responses are proven to be critical in development. Therefore, targeting cells has therapeutic implication resolution. IL-27 a multifunctional cytokine can either promote or inhibit T cell implicated infectious diseases. The aim this study characterize role IL-27/IL-27R...
Various regulatory CD8
Objective: Experimental autoimmune uveitis (EAU) represents in humans, among which B10.RIII and C57BL/6 are the frequently used strains mice, but to date, no study has been reported compare EAU disease between two strains. Here we compared differences morphology, pathology, visual function of retinal inflammation Th1/Th17 immune responses models induced by interphotoreceptor retinoid binding protein (IRBP) strains, using fundus histological examinations, optical coherence tomography,...
To explore whether rs2073244 at PAX9 increased susceptibility for full-term low birth weight infants and indoors passive smoking exposure has a combined effect with on newborn (LBW), 1:2 paired case–control study of LBW newborns was conducted Xiamen University Affiliated Women Children's Hospital from March 2010 to October 2013. The rate indoor in the group higher than it NBW (p = 0.019). GG decreased risk [OR 0.38, 95% CI: (0.15-0.98)] smaller HC 0.44, CI:(0.20-0.98)]. relative excess...
Hepatocyte nuclear factor 4α (HNF4α) is a key regulator of hepatocyte function and has strong therapeutic effect on hepatocellular carcinoma (HCC) by inducing the differentiation hepatoma cell into hepatocytes. Our previous study showed that Tribbles homolog 3 (TRIB3) directly interacts with promotes degradation HNF4α in non-alcoholic fatty liver disease (NAFLD). Disrupting TRIB3–HNF4α interaction cell-permeating peptide, called P-T3H2, stabilized protein. This aimed to assess anti-tumor...
Objective: Data from the surveillance program was collected, to analyze situation of hospitalization and cases death with recorded causes, in Shenzhen, 1995 2014. Situation causes deaths were studied Shenzhen which had been a fast-developing city growing number immigrants so as provide reference for decision-making on related prevention control strategies. Methods: hospitalizations collected program, classified by both International Classification Diseases (ICD)- 9 ICD-10. A database...
Objective: To analyze the epidemiological features, spectrum and case fatality of malignant tumor patients in Shenzhen city, to provide evidence for development prevention treatment strategies on Shenzhen. Methods: All hospitalized including deaths, were monitored from 1995 2014 Shenzhen, data was analyzed by SPSS 20.0 software. Results: There 160 988 inpatients tumors between The top three lung (13.64%), liver (11.13%) breast (7.86%) cancers. Numbers had been rapidly increasing during past...