A5090122545- Computational Drug Discovery Methods
- Pharmacological Effects of Natural Compounds
- Menopause: Health Impacts and Treatments
- Tryptophan and brain disorders
- Estrogen and related hormone effects
- Gut microbiota and health
- Lipoproteins and Cardiovascular Health
- Metabolomics and Mass Spectrometry Studies
- Ginseng Biological Effects and Applications
- Pomegranate: compositions and health benefits
- Liver Disease Diagnosis and Treatment
- Nuclear Receptors and Signaling
- Curcumin's Biomedical Applications
- Ziziphus Jujuba Studies and Applications
- Liver physiology and pathology
- Seaweed-derived Bioactive Compounds
- Menstrual Health and Disorders
- Receptor Mechanisms and Signaling
- Bioactive natural compounds
- Natural product bioactivities and synthesis
- Phytochemicals and Antioxidant Activities
- Essential Oils and Antimicrobial Activity
- Tea Polyphenols and Effects
- Antioxidant Activity and Oxidative Stress
- Monoclonal and Polyclonal Antibodies Research
Nanjing University of Chinese Medicine
2009-2025
Jiangsu Province Hospital
2023
Jiangsu Provincial Academy of Traditional Chinese Medicine
2020-2023
Nanjing University
2006-2021
Background: The pathogenesis of inflammatory bowel disease (IBD) is linked to an intricate association environmental, microbial, and host-related factors. Polysaccharide affects host immunity by regulating the composition metabolism gut microbiota common mechanism resistance. However, efficacy Schisandra chinensis polysaccharide (SCP) in treatment have not been studied. Objective: To explore effect SCP on dextran sodium sulfate (DSS) - induced ulcerative colitis (UC) mice. Materials/Methods:...
Purpose: This study aimed to investigate the potential mechanisms and related bioactive components of ZSS for treatment insomnia. Method: The insomnia model rat induced by PCPA was established. After oral administration extract, general morphological observation, pentobarbital sodium-induced sleep test histopathological evaluation were carried out. Network pharmacology, assisted UHPLC-Q-Exactive-MS/MS analysis, developed identify targets in insomnia, as well corresponding signaling pathways....
Liver fibrosis is a primary threat to public health, owing limited therapeutic options. Germacrone (GM) has been shown exert various curative effects against human diseases, including liver injury. The aim of this study was investigate the pharmacological GM in pathophysiology hepatic and determine its potential mechanisms action. A rat model established via carbon tetrachloride (CCl4 ) treatment, LX-2 cells were stimulated with TGF-β1. on relationship phosphatidylinositol 3-kinase...
Abstract Hepatic stellate cells (HSCs) were activated and secreted excessive amounts of extracellular matrix (ECM) proteins during pathogenetic progress liver fibrosis. Germacrone (GMO) miR-29b can play an important role in inhibiting growth HSCs production type I collagen. GMO co-encapsulated into nanoparticles (NPs) based on poly(ethylene glycol)-block-poly(lactide-co-glycolide) (PEG-PLGA). Then, NPs modified with cyclic RGD peptides (cRGDfK). cRGDfK is effective ligand to bind integrin α...
Cognitive dysfunction increases as menopause progresses. We previously found that estrogen receptors (ERs) contribute to dyslipidemia, but the specific relationship between ERs, dyslipidemia and cognitive remains poorly understood. In present study, we analyzed sequencing data from female hippocampus normal breast aspirate samples Alzheimer's disease (AD) women, results suggest abnormal ERs signaling is associated with dysfunction. replicated a mouse model of postmenopausal status in LDLR-/-...
Curcuma aromatica Salisb. rhizome (CASR) has multifunctional characteristics worldwide and a long history of use as botanical drug with. Currently, it is often used clinically to treat coronary heart disease (CHD) caused by blood stasis syndrome. However, the therapeutic mechanism CASR in treatment CHD remains poorly understood. In study, main chemical constituents were analyzed using UPLC-Q-TOF-MS/MS. Then, its potential against was predicted. Subsequently, pharmacological evaluation...
This study aims to the effective substance and mechanism of Ziziphi Spinosae Semen extract in treatment insomnia based on serum metabolomics network pharmacology. The rat model induced by p-chlorophenylalanine(PCPA) was established. After oral administration extract, general morphological observation, pentobarbital sodium-induced sleep test, histopathological evaluation were carried out. potential biomarkers screened ultra-high performance liquid chromatography-mass spectrometry(UHPLC-MS)...
Schisandra chinensis (SC) is a well-known important traditional Chinese medicine (TCM) that has been used to treat liver disease in China for long time. However, its overall effects and mechanism of action are unclear. The present study aimed explore the potential SC protection against alcoholic injury (ALI). In this research, enable full assessment metabolic changes ALI Sprague-Dawley rats increase our understanding physiological normal pathological states, ultra-high performance liquid...
In our previous study, the efficacy of Schisandra chinensis polysaccharide (SCP) against ulcerative colitis (UC) has been evaluated. At same time, mechanism action was studied from structure and composition intestinal flora metabolism short chain fatty acids (SCFAs). Metabolomics method used to study SCP UC which needed further analysis, research results were carried out conduct correlation analysis in order systematically reveal intervention based on studies. metabolomics, 32 potential...
Carbonizing by stir-frying (CSF) is the most common technology in botanical folk medicines to enhance convergence, hemostasis, and antidiarrheal effects. Sanguisorbae Radix (SR), a well-known herbal medicine China, has extensive therapeutic functions, while charred SR known as an additional product obtained from after CSF. In this study, mass spectrometry was used investigate effect of charring on tannins transformation SR. The findings showed that content level decreased significantly...
Cholesteryl ester transfer protein (CETP) is a promising therapeutic target for cardiovascular diseases. It effectively lowers the low-density lipoprotein cholesterol levels and increases high-density in human plasma. This study identified novel highly potent CETP inhibitors using virtual screening techniques. Molecular docking molecular dynamics (MD) simulations revealed binding patterns of these inhibitors, with top 50 compounds selected according to their predicted affinity....
Background: Curcuma wenyujin rhizome (CWR) is a commonly used Chinese herbal medicine for treating blood stasis in China 1000 of years. However, the underlying mechanism CWR remains unclear. Aims and Objectives: The purpose this study to clarify bioactive stasis. Materials Methods: In study, pharmacological indexes, including hemorheology four coagulation indexes were tested. Bile urine metabolomics engaged by UPLC-Q/TOF-MS. Multivariate statistical analysis screen out differential...
Primary dysmenorrhea (PDM) is a common disorder among women around the world. Two processed products of Curcuma aromatica Salisb. [Zingiberaceae] (CAS) are traditional Chinese medicine (TCM) that have long been used to treat gynecological blood stasis syndrome such as primary dysmenorrhea. The mechanisms and active substances CAS still largely unknown. study aimed establish rat model which investigates differences between pharmacodynamics raw (RCAS) vinegar-processed (VCAS). Histopathology,...
Abstract Background To support the multicomponent pharmacokinetics of Gastrodia elata , a rapid, simple, and sensitive ultra-performance liquid chromatography tandem with mass spectrometry (LC–MS/MS) approach was established for simultaneous quantification gastrodin, parishin A, B, C, E. Methods Five compounds were extracted from plasma by using one-step protein precipitation. The chromatographic separation achieved on C 18 column gradient mobile phase comprising acetonitrile 0.05% formic...