A5030945890- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Neurological Disease Mechanisms and Treatments
- Long-Term Effects of COVID-19
- Barrier Structure and Function Studies
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Neurogenesis and neuroplasticity mechanisms
- COVID-19 Pandemic Impacts
- Autophagy in Disease and Therapy
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Extracellular vesicles in disease
- Pluripotent Stem Cells Research
- Neurological Disorders and Treatments
- Circular RNAs in diseases
- Attention Deficit Hyperactivity Disorder
- Acute Ischemic Stroke Management
- Diet, Metabolism, and Disease
- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Genetics, Aging, and Longevity in Model Organisms
- Nerve injury and regeneration
- Celiac Disease Research and Management
- Cancer-related molecular mechanisms research
University of Medicine and Pharmacy of Craiova
2017-2025
Essen University Hospital
2024
University of Duisburg-Essen
2023-2024
University of Lincoln
2024
Universitätsmedizin Göttingen
2023-2024
Lincolnshire Community Health Services NHS Trust
2024
World Organisation of Family Doctors
2024
Abstract Small extracellular vesicles (sEVs) obtained from mesenchymal stromal cells (MSCs) promote neurological recovery after middle cerebral artery occlusion (MCAO) in young rodents. Ischemic stroke mainly affects aged humans. MSC-sEV effects on rodents had not been assessed. In a head-to-head comparison, we exposed (4–5 months) and (19–20 male Sprague–Dawley rats to permanent distal MCAO. At 24 h, 3 7 days post-stroke, vehicle or MSC-sEVs (2 × 10 6 2 MSC equivalents/kg) were...
As the population ages, promoting healthy aging through targeted interventions becomes increasingly crucial. Growing evidence suggests that dietary can significantly impact this process by modulating fundamental molecular pathways. This review focuses on potential of strategies in and mechanisms which specific nutrients patterns influence key pathways involved cellular repair, inflammation, metabolic regulation. Caloric restriction, intermittent fasting, Mediterranean diet, as well ketogenic...
Worldwide, millions of individuals suffer an ischemic stroke each year, causing major disability, especially in the elderly, where is number one cause disability. However, to date, no effective therapy exists that targets functional recovery after stroke. After necrosis, neuroinflammation a common feature acute and obstacle tissue restoration. In lesioned area, dying neurons release chemotactic signals, such as fractalkine/CX3CL1, which evoke “eat-me” signals are recognized by microglia...
The identification and quantification of sources vaccine hesitancy among industrial workers in Romania have become crucial for developing effective strategies to facilitate the vaccination process. Our study included employees, both with without comorbidities, who work companies. goal was develop a scale assess COVID-19 Romania. This proposed has been designated as Romanian Vaccine Hesitancy (RO-CVH) scale. survey encompassed demographic characteristics respondents questions related their...
Vaccine hesitancy remains a critical barrier to achieving widespread vaccination, particularly in settings with limited public trust and high exposure misinformation. This study aims measure the level of vaccine hesitancy, identifying factors contributing it, evaluate effectiveness two targeted interventions-group individual counseling-designed address among employees seven industrial companies Romania during Coronavirus disease 2019 (COVID-19) pandemics. A total 256 participants were...
Cerebrovascular diseases are the second leading cause of death worldwide. Despite significant research investment, only available therapeutic options mechanical thrombectomy and tissue plasminogen activator thrombolysis. None more than a thousand drugs tested on animal models have proven successful in human clinical trials. Several factors contribute to this poor translation data from stroke-related stroke patients. Firstly, our understanding molecular cellular processes involved recovering...
Stroke remains a debilitating cerebrovascular condition associated with oxidative stress, while COVID-19 has emerged as global health crisis multifaceted systemic implications. This study investigates the hypothesis that patients experiencing acute ischemic stroke alongside exhibit elevated stress markers and altered antioxidant defense mechanisms compared to those stroke. We conducted single-center prospective cross-sectional investigate balance through damage markers: TBARS (thiobarbituric...
The concept of paraneoplastic syndromes encompasses a spectrum indirect clinical manifestations caused by secretion bioactive products malignant cells. Paraneoplastic glomerulopathy represent distinct entity where nephrotic syndrome can arise as manifestation underlying malignancies, particularly solid tumors. Membranous nephropathy is notably associated with such highlighting the intricate relationship between and cancer. present study reports case 44-year-old Caucasian male, smoker (22...
The major aim of stroke therapy is to stimulate brain repair and improve behavioral recovery after cerebral ischemia. One option endogenous neurogenesis in the subventricular zone direct newly formed neurons damaged area. However, only a small percentage these survive, many do not reach area, possibly because corpus callosum impedes migration zone-derived stem cells into lesioned cortex. A second obstacle cell strong inflammatory reaction induced by ischemia, whereby associated phagocytic...
Despite the clinical significance of post-stroke angiogenesis, a detailed phenotypic analysis pre-stroke vascular remodeling and angiogenesis had not yet been done in model focal ischemia. In this study, using BrdU-labeling proliferating cells immunofluorescence pre- rats, we found that, (i) BrdU administered before stroke was incorporated preferentially into nuclei endothelial lining lumen existing blood vessels newly born neurons dentate gyrus but subventricular zone or microglia, (ii)...
In response to the intricate clinical challenges posed by intersection of COVID-19 and acute ischemic stroke, Neuropsychiatry Hospital Craiova, Romania, initiated a comprehensive study. This research aims unravel impacts pulmonary complications on stroke outcomes, comparing patients with concurrent SARS-CoV-2 infection those without. The study integrates assessments, acknowledging significant role respiratory involvement plays in progression prognosis during pandemic. By systematically...
Vaccine hesitancy remains a significant public health challenge, particularly in rural populations where geographic and socioeconomic barriers exacerbate the issue. This study aimed to examine factors influencing vaccine hesitancy, focusing on influenza vaccinations urban communities Romania. The was conducted between October 4 30, 2024, across 16 family medicine practices, including seven nine areas from A 13-item questionnaire, assessing such as fear of adverse effects, distrust vaccines,...
Aim: Stroke is one of the leading causes death and disability worldwide. Plasma biomarkers have long been used to evaluate physiological or pathological processes make predictions about outcome stroke patients. The current systematic review focused on genetic plasma as a new potential prognostic indicator for post-stroke recovery. aim present assess associated with predict Methods: search strategy PubMed Web Science databases identified 166 studies that investigated in patients between 2017...
Background: Social prescribing initiatives are tailored coaching programs created to assist participants in improving their personal circumstances and might constitute a creative way enhance public preventive health as we work toward providing universal financially sustainable healthcare. Methods: We conducted scoping review with the aim of summarizing main global trends on social identify existing resources potential targets Romania. Results: One concerns that arose from this is lack...
Abstract The major aim of stroke therapy is to stimulate brain repair and improve behavioral recuperation after cerebral ischemia. One option endogenous neurogenesis in the sub-ventricular zone (SVZ) direct newly formed neurons damaged area. However, only a small percentage these survive and, those that do, many will not reach area possibly because corpus callosum impedes migration SVZ-derived stem cells into lesioned cortex. A second obstacle cell strong inflammatory reaction induced by...