A5010899922- Acute Kidney Injury Research
- Renal function and acid-base balance
- Nitric Oxide and Endothelin Effects
- Cardiac Ischemia and Reperfusion
- Diabetic Foot Ulcer Assessment and Management
- Laser Applications in Dentistry and Medicine
- Organ Donation and Transplantation
- Botulinum Toxin and Related Neurological Disorders
- Cardiac Arrest and Resuscitation
- Chronic Kidney Disease and Diabetes
- Electrolyte and hormonal disorders
- Wound Healing and Treatments
- Birth, Development, and Health
- Poisoning and overdose treatments
- Rural Development and Agriculture
- Reproductive Biology and Fertility
- Organ Transplantation Techniques and Outcomes
- Heme Oxygenase-1 and Carbon Monoxide
- Eicosanoids and Hypertension Pharmacology
- Veterinary Medicine and Surgery
- Erythrocyte Function and Pathophysiology
- Drug-Induced Hepatotoxicity and Protection
- Bone fractures and treatments
- Renin-Angiotensin System Studies
- Pediatric Urology and Nephrology Studies
Johns Hopkins University
2013-2024
University of Colorado Denver
1987-2019
The University of Texas MD Anderson Cancer Center
2001-2008
Nenagh Hospital
2006
Weatherford College
2004
University of Toledo Medical Center
1999-2002
University of Illinois Urbana-Champaign
1975-2001
University of Colorado Health
1981-2000
University of Colorado Anschutz Medical Campus
1988-2000
University of Limerick
1998
Nitric oxide (NO), among several other functions, may play a role in hypoxia and reoxygenation injury due to its free radical nature high reactivity with the superoxide yield peroxynitrite, an oxidant molecule. The present study was undertaken evaluate potential for NO, either endogenous or exogenous, model of hypoxia/reoxygenation (H/R) freshly isolated rat proximal tubules. NO synthase activity, as assessed by conversion L-[3H]arginine L-[3H]citrulline, detected normoxic This activity...
The present study examined whether a pre- or postischemic infusion of verapamil (V) nifedipine (N), drugs which block calcium (Ca++) influx across plasma membranes, provides protection against ischemic acute renal failure (ARF) in dogs. Renal hemodynamics and excretory function were 1 h (initiation phase) 24 (maintenance after 40-min intrarenal norepinephrine (NE). In each case, the uninfused contralateral kidney served as control. Four groups studied: (a) dogs receiving NE alone; (b) an V...
Ethylene oxide ("EtO") is an industrially made volatile organic compound and a known human carcinogen. There are few reliable reports of ambient EtO concentrations around production end-use facilities, however, despite major exposure concerns. We present
The pathogenetic factors involved in norepinephrine- (NE) induced reversible acute renal failure (ARF) were examined untreated (U) and mannitol-treated (M) animals. At 3 24 h after NE infusion blood flow (RBF) was significantly higher M compared to U animals (174 vs. 138 191 148 ml/min, respectively, both P less than 0.05). h, glomerular filtration rate (GFR) (8 4 0.01), while at protection even greater (18 0.01). In proximal tubule pressure (Pt) lower 1 before (13 23 mmHg, 0.01); from Pt...
Ischemic preconditioning has been shown to ameliorate injury due subsequent ischemia in several organs. However, relatively little is known about and the kidney. To address this, rats were randomized control (C, N = 14), 2 min of ischemic (P2 10), 3 periods separated by 5 reflow (P2,3 7), or three (P5,3 6) prior 45 bilateral renal followed 24 hours reperfusion. We observed a lower serum creatinine after P2, but not P5, compared with C. Histology was examined C groups demonstrated less severe...
Renal clearance and recollection micro-puncture experiments were conducted to evaluate the possible role of a distal tubular feedback mechanism in phenomenon renal autoregulation dogs. Single nephron glomerular filtration rate (SNGFR) was measured from collection sites both proximal (proximal SNGFR) tubules (distal SNGFR). autoregulatory behavior assessed by evaluating response SNGFR reduction arterial pressure imposed means an aortic constrictor. Whole kidney function evaluated parallel...
Objective: This study explored the outcome of applying red/near-infrared light therapy using light-emitting diodes (LEDs) pulsed with three different frequencies transcranially to treat traumatic brain injury (TBI) in Veterans. Background: Photobiomodulation (PBMT) LEDs has been shown have positive effects on TBI humans and animal models. Materials methods: Twelve symptomatic military Veterans diagnosed chronic >18 months post-trauma received transcranial PBMT (tPBMT) two neoprene pads...
The early pathophysiological changes in acute urate nephropathy were investigated a rat model using micropuncture, clearance, and morphologic methods. Plasma was increased from 1.2 +/- 0.6 to 20.1 3.1 mg/100 ml (P less than 0.001). Urinary rose 24.3 5.1 142.2 21.0 Renal plasma flow glomerular filtration rate fell 17 14% of control values, respectively, urine decreased 11.3 4.8 4.2 2.2 mul/min (all P 0.005) Superficial nephron that the whole kidney (70 vs. 86%). Both proximal distal tubular...
Forty-nine consecutive subjects with established diabetic peripheral neuropathy were treated monochromatic near-infrared photo energy (MIRE) to determine if there was an improvement of sensation. Loss protective sensation characterized by Semmes-Weinstein monofilament values 4.56 and above present in 100% (range, 6.45), 42 (86%) had 5.07 or higher. The ability discriminate between hot cold absent (54%) impaired (46%) both groups prior the initiation MIRE treatment. On basis values, 48 (98%)...
Objective: to determine whether restoration of sensation, impaired due diabetic peripheral neuropathy (DPN), would reduce the number falls and fear falling improve activities daily living (ADL) in a Medicare-aged population.
To determine nonenteric sites associated with Escherichia coli isolates in dogs and the antimicrobial susceptibilities of isolates.Retrospective study.17,000 canine specimens.Medical records 17,000 specimens submitted for bacteriologic culture were examined number isolations E was determined. For these cases, further respect to body system involvement, sex, concurrent infection other species bacteria, susceptibility.674 (424 from urine, 62 skin, 52 respiratory tract, 45 ear, 43 female...
This study explored the outcome of applying red/near-infrared light therapy using light-emitting diodes (LEDs) pulsed with three different frequencies transcranially to treat traumatic brain injury (TBI) in Veterans.
Progressive mitochondrial Ca2+ accumulation and respiratory dysfunction have been observed during reperfusion after renal ischemia. The present study demonstrated that normal mitochondria, isolated in the presence of high concentrations, are capable accumulating large amounts vitro exhibit depressed rates. Since mitochondria from reperfused ischemic tissue may be exposed to concentrations isolation procedure, examined effect versus vivo loading on function acute failure (ARF) anesthetized...