A5022337039- Palliative Care and End-of-Life Issues
- Dermatology and Skin Diseases
- Veterinary Oncology Research
- Monoclonal and Polyclonal Antibodies Research
- Childhood Cancer Survivors' Quality of Life
- HER2/EGFR in Cancer Research
- Nail Diseases and Treatments
- Skin and Cellular Biology Research
- Peroxisome Proliferator-Activated Receptors
- Infectious Diseases and Mycology
- Cancer survivorship and care
- Economic and Financial Impacts of Cancer
- Virus-based gene therapy research
- Nursing Roles and Practices
- Safe Handling of Antineoplastic Drugs
- Interprofessional Education and Collaboration
- Cancer Treatment and Pharmacology
- Veterinary Medicine and Surgery
- Migraine and Headache Studies
- Drug-Induced Adverse Reactions
- Fatty Acid Research and Health
- Radiopharmaceutical Chemistry and Applications
- Allergic Rhinitis and Sensitization
- Immune Response and Inflammation
- Family Support in Illness
Edinburgh Napier University
2010-2025
University of Stirling
2022-2024
Campbell Collaboration
2024
Rudd Foundation
2024
NHS Lothian
2024
University of Illinois Urbana-Champaign
2009-2023
University of Missouri
2019-2022
University of the West of Scotland
2022
Rubius Therapeutics (United States)
2021
Macmillan Cancer Support
2016-2020
Abstract Purpose: Therapeutic nanoparticles are designed to deliver their drug payloads through enhanced permeability and retention (EPR) in solid tumors. The extent of EPR its variability human tumors is highly debated has been proposed as an explanation for variable responses therapeutic clinical studies. Experimental Design: We assessed the effect patients using a 64Cu-labeled nanoparticle, 64Cu-MM-302 (64Cu-labeled HER2-targeted PEGylated liposomal doxorubicin), imaging by PET/CT....
Background Cytotoxic drugs, including chemotherapy, potentially pose significant risks to cancer nurses. Therefore, it is important take measures protect them from the health effects associated with these drugs. Aim To determine UK nurses' perceptions and experiences regarding potential exposure cytotoxic their knowledge of hazards, use personal protective equipment (PPE) closed system transfer devices (CSTDs), perceived effects. Method A cross-sectional survey was conducted across UK,...
This phase 1 dose-escalation trial studied MM-302, a novel HER2-targeted PEGylated antibody–liposomal doxorubicin conjugate, in HER2-positive locally advanced/metastatic breast cancer. Patients were enrolled four cohorts: MM-302 monotherapy (8, 16, 30, 40, and 50 mg/m2 every 4 weeks [q4w]); (30 or 40 q4w) plus trastuzumab (4 mg/kg q2w); mg/m2) (6 mg/kg) q3w; cyclophosphamide (450 q3w. Sixty-nine patients treated. The most common adverse events (AEs) fatigue nausea. Grade 3/4 AEs of special...
Abstract Objective To determine whether methicillin-resistant staphylococci from dogs expressed the mecA gene and to what proportion of canine staphylococcal isolates positive for were resistant oxacillin other antibiotics. Sample Population 25 (10 coagulase-positive 15 coagulase-negative) methicillin-susceptible (8 7 isolated dogs. Procedure All strains tested methicillin resistance by use agar screening identified standard techniques. Minimum inhibitory concentrations 16 antibiotics...
While life is experienced continuously, we tend to perceive it as a series of events. At neural level, this event segmentation process has been linked changes in states. An open question whether these states differ with age. Participants (N = 577) from the CamCAN cohort viewed an 8-min movie during fMRI. A data-driven state method was used identify changes. To study effects age, participants were sorted into 34 age groups. We show that become significantly longer increasing particularly...
The development and use of novel systemic anticancer therapy (SACT) treatments are advancing rapidly. While cytotoxic drugs have traditionally been the cornerstone treatment, they increasingly used alongside agents. This study aims to assess factors affecting adherence safe-handling precautions, enhance safety protocols, minimize potential occupational exposure hazards in clinical environments, increasing their capacity for treatments. Cross-sectional, online survey oncology nurses across UK...
Abstract Data on fifty horses with hereditary equine regional dermal asthenia (HERDA; ‘hyperelastosis cutis’) were collected clinical, histopathological, ultrastructural and immunohistological findings. All Quarter or of horse ancestry. Pedigree evaluation strongly supported an autosomal recessive mode inheritance. The most common lesions seromas/haematomas, open wounds, sloughing skin, loose, easily tented skin that did not return to its initial position. Definitive diagnosis could be made...
Overactive bladder (OAB) is a common medical condition with significant economic and humanistic burden. Inadequately managed OAB may exacerbate or result in comorbidities such as depression, falls, urinary tract infections, which can further increase the burden to health care system. Anticholinergics are often prescribed for management of incontinence ("wet" OAB). However, research has shown that patient adherence persistence anticholinergic therapy poor, approximately 80% patients...
Fourteen cats received either daily prednisolone (4.4 mg/kg per os [PO]) or dexamethasone (0.55 PO) for 56 days. These doses were clinically equipotent. Serum fructosamine and urine glucose measured on days 0, 28, 56. Insulin sensitivity, tolerance, peak insulin secretion in each group prior to at the end of courses glucocorticoid administration. On day 56, prevalence glucosuria was significantly greater (P=0.027), a trend seen toward concentrations (P=0.083) dexamethasone-treated compared...
To evaluate the introduction of Advanced Nurse Practitioners in a specialist, multi-professional palliative care context. The objective is to explore core domains and competencies advanced nurse practitioner role context.New models health service delivery are emerging alongside expanded levels autonomy, skills decision-making for nurses midwives. This has resulted some confusion community internationally about professional scope practitioner.A qualitative evaluation study (n = 21).Three...
To compare pathologic changes of the horizontal ear canal associated with chronic severe otitis externa between Cocker Spaniels and dogs other breeds.Retrospective study.80 that required total ablation lateral bulla osteotomy.Medical records were reviewed for breed, sex, age at time surgery. Histologic specimens from evaluated by a single examiner overall tissue response pattern scored sebaceous gland hyperplasia, ceruminous ectasia, fibrosis, pigment-laden macrophages, osseous metaplasia.48...
To determine nonenteric sites associated with Escherichia coli isolates in dogs and the antimicrobial susceptibilities of isolates.Retrospective study.17,000 canine specimens.Medical records 17,000 specimens submitted for bacteriologic culture were examined number isolations E was determined. For these cases, further respect to body system involvement, sex, concurrent infection other species bacteria, susceptibility.674 (424 from urine, 62 skin, 52 respiratory tract, 45 ear, 43 female...
Inverted papillomas of the skin occurred in five dogs. Lesions were 1–2 cm, circumscribed, flask-like structures below level surrounding normal skin. Walls consisted hyperplastic epidermis, forming thin papillary projections on fibrovascular stalks. Cells stratum granulosum had clear cytoplasm, numerous keratohyalin-like granules various sizes, and poorly defined intranuclear inclusions. These cells stained positively for papillomavirus group-specific antigens by both...
Papillomavirus was identified in pigmented epidermal plaques (PEP) from three dogs: a miniature schnauzer with hyperadrenocorticism and hypoglobulinemia, an American Staffordshire terrier Pomeranian unconfirmed hypothyroidism. Squamous cell carcinoma (SCC) arose within several the Pomeranian. Clinical improvement coincided first two cases treatment of concurrent disease administration low-dose oral interferon-α. This is report PEP The potential for malignant transformation to SCC emphasizes...
Fourteen cats were given immunosuppressive doses of either prednisolone (4·4 mg/kg/day) or dexamethasone (0·55 for 56 days. Complete blood counts, serum biochemistry profiles and urinalyses performed on days 0 56, liver biopsies taken laparoscopically day because evidence hepatic disease the profiles. There significant increases in cats' mean white cell neutrophil counts monocyte decreases their lymphocyte eosinophil counts. consistent concentrations albumin, glucose, triglycerides...