A5068566490- Alzheimer's disease research and treatments
- Prion Diseases and Protein Misfolding
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Mitochondrial Function and Pathology
- Cholinesterase and Neurodegenerative Diseases
- Olfactory and Sensory Function Studies
- Genetic Neurodegenerative Diseases
- RNA regulation and disease
- Neuroscience and Neuropharmacology Research
- Electron Spin Resonance Studies
- Nuclear Receptors and Signaling
- Nerve injury and regeneration
- Advanced MRI Techniques and Applications
- Lanthanide and Transition Metal Complexes
- Insect Resistance and Genetics
- Psychosomatic Disorders and Their Treatments
- Personality Disorders and Psychopathology
- Neurogenesis and neuroplasticity mechanisms
- Supramolecular Self-Assembly in Materials
- Biochemical and Structural Characterization
- Curcumin's Biomedical Applications
- Parkinson's Disease Mechanisms and Treatments
- Psychotherapy Techniques and Applications
Linköping University
2012-2023
The pathology of Alzheimer's disease (AD) is characterized by the presence extracellular deposits misfolded and aggregated amyloid-β (Aβ) peptide intraneuronal accumulation tangles comprised hyperphosphorylated Tau protein. For several years, natural compound curcumin has been proposed to be a candidate for enhanced clearance toxic Aβ amyloid. In this study we have studied potency feeding as drug alleviate toxicity in transgenic Drosophila. longevity well locomotor activity five different AD...
Neuroinflammation, particularly that involving reactive microglia, the brain's resident immune cells, is implicated in pathogenesis of major neurodegenerative diseases. However, early markers this process are high demand. Multiple studies have reported changes ribosomal protein (RP) expression during neurodegeneration, but significance these remains unclear. Ribosomes evolutionarily conserved synthesizing machines, and although commonly viewed as invariant, accumulating evidence suggest...
Selective vulnerability is an enigmatic feature of neurodegenerative diseases (NDs), whereby a widely expressed protein causes lesions in specific cell types and brain regions. Using the RiboTag method mice, translational responses five neural subtypes to acquired prion disease (PrD) were measured. Pre-onset onset timepoints chosen based on longitudinal electroencephalography (EEG) that revealed gradual increase theta power between 10- 18-weeks after injection, resembling clinical human PrD....
The aim of this study was to analyze whether self-reported attachment style (measuring avoidance and anxiety) among adolescents associated with dissociative symptoms, in addition potentially traumatic experiences. A group consisting 462 completed three self-assessment questionnaires: Linkoping Youth Life Experience Scale (LYLES), Experiences Close Relationships, modified version (ECR) Dissociation Questionnaire Sweden (Dis-Q-Sweden). Self-reported had a stronger association symptoms than...
Brain amyloid plaques are a hallmark of Alzheimer's disease (AD), and primarily consist aggregated Aβ peptides. While 1-40 1-42 the most abundant, number other peptides have also been identified. Studies indicated differential toxicity for these various peptides, but in vivo has not systematically tested. To address this issue, we generated improved transgenic Drosophila UAS strains expressing 11 pertinent flies were by identical chromosomal insertion, hence removing any position effects,...
Abstract Genetic variation is a primary determinant of phenotypic diversity. In laboratory mice, genetic can be serious experimental confounder, and thus minimized through inbreeding. However, generalizations results obtained with inbred strains must made caution, especially when working complex phenotypes disease models. Here we compared behavioral characteristics C57Bl/6—the strain most widely used in biomedical research—with those 129S4. contrast to 129S4, C57Bl/6 demonstrated high...
Abstract Although Huntington’s disease (HD) is classically defined by the selective vulnerability of striatal projection neurons, there increasing evidence that cerebellar degeneration modulates clinical symptoms. However, little known about cell type-specific responses neurons in HD. To dissect early mechanisms cerebellum and cerebrum, we analyzed translatomes neuronal types from both regions a new HD mouse model. For this, HdhQ200 knock-in mice were backcrossed with calm 129S4 strain, to...
Purpose The purpose of this study was to develop an X‐Band electron paramagnetic resonance imaging protocol for visualization oxidative stress in biopsies. Methods developed based on spin trapping with the cyclic hydroxylamine probe 1‐hydroxy‐3‐methoxycarbonyl‐2,2,5,5‐tetramethylpyrrolidine and EPR imaging. Computer software deconvolution back‐projection image. A phantom containing radicals known spatial characteristic used evaluation protocol. As a demonstration technique performed six...
Over the past several years, toxic mechanism of proliferating misfolded proteins (MPs) as initiators and drivers neurodegeneration has gained momentum. Nonetheless, notion selective v ...
The basis for selective vulnerability of certain cell types misfolded proteins (MP) in neurodegenerative diseases is largely unknown. This knowledge crucial understanding disease progression relation to MP spreading the CNS. We assessed this issue Drosophila, by specific expression human Aβ1-42 associated with Alzheimer's disease. Expression various neurons resulted concentration dependent severe phenotypes, and intraneuronal ringtangle like aggregates immature fibril properties when...
Abstract Selective vulnerability is an enigmatic feature of neurodegenerative diseases (NDs), whereby a widely expressed protein causes lesions in specific brain regions and cell types. This selectivity may arise from cells possessing varying capacities to regain proteostasis when stressed by cytotoxic conformers. Using the RiboTag method mice, translational responses five neural subtypes acquired prion disease (PrD) were measured. Pre-onset onset timepoints chosen based on longitudinal...
A bstract Genetic variation is a primary determinant of phenotypic diversity within populations. In laboratory mice, genetic has often been regarded as serious experimental confounder, and thus minimized through inbreeding. However, generalizations results obtained with inbred strains need to be made caution. Effects background on traits controlled, especially when working complex phenotypes disease models. Here we compared behavioral parameters C57Bl/6 – the mouse strain most widely used...
ABSTRACT Although Huntington’s disease (HD) is predominantly defined by selective vulnerability of striatal projection neurons, there increasing evidence that cerebellar degeneration modulates clinical symptoms. However, little known about cell type-specific responses neurons in HD. To dissect early mechanisms the cerebellum and cerebrum, we analyzed translatomes neuronal types from both regions a new HD mouse model. For this, HdhQ200 knock-in mice were backcrossed with calm, 129S4 strain,...