A5060417634- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Genomic variations and chromosomal abnormalities
- Chronic Lymphocytic Leukemia Research
- CAR-T cell therapy research
- Lymphoma Diagnosis and Treatment
- Genetics and Neurodevelopmental Disorders
- RNA modifications and cancer
- DNA Repair Mechanisms
- Chromosomal and Genetic Variations
- Health Literacy and Information Accessibility
- Mobile Health and mHealth Applications
- Ubiquitin and proteasome pathways
- CRISPR and Genetic Engineering
- Sleep and related disorders
- Telemedicine and Telehealth Implementation
- Natural product bioactivities and synthesis
- Family and Patient Care in Intensive Care Units
- Flavonoids in Medical Research
- Advances in Oncology and Radiotherapy
- Childhood Cancer Survivors' Quality of Life
- Phytochemicals and Antioxidant Activities
- Patient Satisfaction in Healthcare
- Frailty in Older Adults
- Intensive Care Unit Cognitive Disorders
University of Chicago
2022-2025
University of Michigan
2022-2023
Sechenov University
2023
Royal College of Surgeons in Ireland
2023
Poznan University of Medical Sciences
2023
Distal enhancers play critical roles in sustaining oncogenic gene-expression programs. We identify aberrant enhancer-like activation of GGAA tandem repeats as a characteristic feature B-cell acute lymphoblastic leukemia (B-ALL) with genetic defects the ETV6 transcriptional repressor, including ETV6-RUNX1+ and ETV6-null B-ALL. show that repeat are direct activators previously identified ETV6-RUNX1+/- like B-ALL "signature" genes, likely leukemogenic driver EPOR. When restored to...
Abstract High expression of MYC and its target genes identify germinal center B-cell diffuse large lymphomas (GCB-DLBCL) associated with poor outcomes. We used CRISPR-interference profiling human lymphoma cell lines to define essential enhancers in the locus non-immunoglobulin rearrangement partner loci, including a recurrent between BCL6 control region. GCB-DLBCL without are dependent on an evolutionarily-conserved enhancer we name “germinal 1” (GME-1), which is activated by transcription...
High expression of MYC and its target genes define a subset germinal center B-cell diffuse large lymphoma (GCB-DLBCL) associated with poor outcomes. Half these high-grade cases show chromosomal rearrangements between the locus heterologous enhancer-bearing loci, while focal deletions adjacent non-coding gene PVT1 are enriched in -intact cases. To identify genomic drivers activation, we used high-throughput CRISPR-interference (CRISPRi) profiling candidate enhancers rearrangement partner loci...
: A novel series of Apigenin bioisosteres [1(4-chlorophenyl)-3-phenyl prop-2-ene-1-one] non-cyclic derivatives (4a-4c) and [7-hydroxy-2-phenyl-4H-chromen-4-one] cyclic (9a- 9d) were synthesized. The newly synthesized apigenin confirmed using UV, IR, NMR, mass spectroscopic methods. antioxidant, antibacterial, anti-cancer activities all compounds assessed the DPPH free radical scavenging capacity, disc diffusion method, in vitro MTT assay on human breast cancer MCF-7 cell line. Almost had...
The role of sufficient vision in self-management is salient with respect to the growing prevalence eHealth-based interventions for chronic diseases. However, relationship between insufficient and has been understudied.We aimed assess differences access use technology among adults without at an academic urban hospital.This observational study hospitalized adult general medicine patients that part a larger quality improvement called hospitalist study. provided demographic health literacy data...
<div>Abstract<p>Distal enhancers play critical roles in sustaining oncogenic gene-expression programs. We identify aberrant enhancer-like activation of GGAA tandem repeats as a characteristic feature B-cell acute lymphoblastic leukemia (B-ALL) with genetic defects the <i>ETV6</i> transcriptional repressor, including <i>ETV6–RUNX1</i><sup>+</sup> and <i>ETV6</i>-null B-ALL. show that repeat are direct activators previously identified...
<div>Abstract<p>Distal enhancers play critical roles in sustaining oncogenic gene-expression programs. We identify aberrant enhancer-like activation of GGAA tandem repeats as a characteristic feature B-cell acute lymphoblastic leukemia (B-ALL) with genetic defects the <i>ETV6</i> transcriptional repressor, including <i>ETV6–RUNX1</i><sup>+</sup> and <i>ETV6</i>-null B-ALL. show that repeat are direct activators previously identified...
<p>Contains Supplementary Figures 1-12 and additional information about tables</p>
<p>Contains Supplementary Figures 1-12 and additional information about tables</p>
Introduction:The relationship between vitamin D receptor (VDR) polymorphisms and cardiovascular disease (CVD) is unclear.This study explores the correlation VDR genotypes, plasma concentrations of metabolites, CVD occurrence metabolic disorders.Method: Fifty-eight patients with were included.ApaI rs7975232 TaqI rs731236 genotyped using PCR-RFLP method.Circulating 25-hydroxyvitamin-D2, 25-hydroxyvitamin-D3, 3-epi-25-hydroxyvitamin D3 measured by a validated UPLC-MS/MS method.Results: ApaI...