A5103139395- Immunotherapy and Immune Responses
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Renal Transplantation Outcomes and Treatments
- T-cell and B-cell Immunology
- Cytomegalovirus and herpesvirus research
Institut d'Investigació Biomédica de Bellvitge
2017-2018
Universitat de Barcelona
2018
Chronic immunosuppression promotes nonmelanocytic squamous cell carcinoma (SCC) after kidney transplantation. Adaptive and innate immunity play a key role controlling tumor growth are influenced by different immunosuppressive agents. We hypothesized that functional impairment of tumor-specific T responses due to calcineurin inhibitors (CNI) could contribute SCC development, whereas conversion mammalian target rapamycin (mTOR-i) recover this protective immune response.Peripheral against main...
Donor-specific (d-sp) interferon gamma enzyme-linked immunosorbent spot (d-sp ELISPOT) and Panel of reactive T-cell (PRT) ELISPOT assays have been developed to detect alloreactive memory T (Tmem) cells in order estimate the risk acute rejection after kidney transplantation. Adding IL15 PRT assay (PRT+IL15) may uncover presence pathogenic CD28-Tmem. Face-to-face comparisons these not done yet. We performed pre-transplant d-sp (±IL15, against six B-cell lines) 168 consecutive transplant...