A5103132461- Insect Resistance and Genetics
- Insect-Plant Interactions and Control
- Alzheimer's disease research and treatments
- Monoclonal and Polyclonal Antibodies Research
- Extracellular vesicles in disease
- CRISPR and Genetic Engineering
- Insect symbiosis and bacterial influences
- Metabolism, Diabetes, and Cancer
- Connexins and lens biology
- Neuroblastoma Research and Treatments
- Neuroscience and Neuropharmacology Research
- Amphibian and Reptile Biology
- Cancer, Hypoxia, and Metabolism
- Amino Acid Enzymes and Metabolism
- Insect behavior and control techniques
- MicroRNA in disease regulation
- Plant Molecular Biology Research
- RNA Interference and Gene Delivery
- Plant Gene Expression Analysis
- Genetic and Environmental Crop Studies
- Therapeutic Uses of Natural Elements
- Autophagy in Disease and Therapy
- Medicinal Plant Pharmacodynamics Research
- Insect Pest Control Strategies
- Aquaculture disease management and microbiota
Agricultural Genomics Institute at Shenzhen
2022-2024
Chinese Academy of Agricultural Sciences
2022-2024
Ministry of Agriculture and Rural Affairs
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Peking University
2024
Chinese Institute for Brain Research
2024
Huazhong Agricultural University
2023
Tea Research Institute
2023
Chongqing Medical University
2017-2022
Chengdu Institute of Biology
2022
Abstract Background The role of physical exercise in the prevention Alzheimer’s disease (AD) has been widely studied. Microglia play an important AD. Triggering receptor expressed myeloid cells 2 (TREM2) is on microglia and known to mediate microglial metabolic activity brain glucose metabolism. However, relationship between metabolism during running APP/PS1 mice remains unclear. Methods Ten-month-old male wild-type were randomly divided into sedentary groups or (AD_Sed, WT_Sed, AD_Run...
•Population genomics reveals global population connectivity in the cotton bollworm.•Adaptation highly connected populations of a major agricultural pest.•Genetic variation enables evolution cold tolerance bollworm.•Climate and human activity shape crop pest Helicoverpa armigera. The bollworm, armigera, is set to become most economically devastating world, threatening food security biosafety as its range expands across globe. Key understanding eco-evolutionary dynamics H. thus management, an...
The major plant pest fall armyworm (FAW), Spodoptera frugiperda, is native to the Americas and has colonized Africa Asia within Eastern hemisphere since 2016, causing severe damage multiple agricultural crop species. However, genetic origin of these invasive populations requires more in-depth exploration. We analysed variation across genomes 280 FAW individuals from both Americas. global range-wide structure shows that in America experienced deep differentiation, largely consistent with...
BACKGROUND:There are few data on the prevalence of low T3 (triiodothyronine) syndrome in patients with non-dialysis chronic kidney disease (CKD) and it is unclear whether can be used to predict progression CKD. MATERIAL AND METHODS:We retrospectively studied 279 who had been definitively diagnosed CKD, without needing maintenance dialysis. Thyroid function was analyzed all enrolled subjects incidence thyroid dysfunction (low syndrome, T4 subclinical hypothyroidism) at different stages CKD...
Abstract Understanding the genetic basis of pest adaptive evolution and risk adaptation in response to climate change is essential for development sustainable agricultural practices. However, climatic Asian corn borer (ACB), Ostrinia furnacalis, main Asia Oceania, poorly understood. Here, we revealed genomic loci underlying ACB by integrating population environmental factors. We assembled a 471-Mb chromosome-scale reference genome resequenced 423 individuals covering 27 representative...
Previous studies have indicated that disease activity, psychological symptoms and social support were associated with health-related quality of life (HRQoL) in patients inflammatory bowel diseases(IBD). However, it is unclear how interact to affect HRQoL. The main purpose this study was examine the mediation effect relationship between HRQoL.This a cross-sectional study, which collected data using convenience sampling, December 2016 March 2018, from Third XiangyaHospital Central South...
Previous studies have reported that exercise could improve the plasticity of hippocampal synapses. However, effects on synapses in hippocampus Alzheimer's disease (AD) are not completely known. In this study, thirty 12-month-old male APP/PS1 double transgenic mice were randomly divided into a sedentary group (n = 15) and running 15). Fifteen wild-type littermates assigned to control While treadmill for four months, did run during study period. After Morris water maze testing, five each...
Background The objective of this study was to use machine learning algorithms construct predictive models for atrial fibrillation (AF) in elderly patients with coronary heart disease (CHD) and type 2 diabetes mellitus (T2DM). Methods diagnosis treatment data CHD T2DM, who were treated four tertiary hospitals Chongqing, China from 2015 2021, collected. Five algorithms: logistic regression, regression+least absolute shrinkage selection operator, classified regression tree (CART), random forest...
The pink stem borer, Sesamia inferens (Walker), is a significant polyphagous pest historically restricted to regions south of N34° latitude. However, with changes in global climate and farming practices, the distribution this moth has progressively exceeded its traditional limit 34° N encompassed most North China. genetic adaptations S. remain incompletely understood due lack high-quality genome resources. Here, we sequenced using PacBio Hi-C technology, yielding assembly 865.04 Mb contig...
The proliferative ability of oligodendrocyte progenitor cells (OPCs) varied markedly under different culture conditions. Astrocytes (ASTs) have been verified to play a major role in regulating the proliferation OPCs through direct contact. However, mechanisms not fully clarified. To investigate effect and mechanism AST OPC co-culture conditions, we analyzed all connexins comprehensively mono-culture, AST-secreted cell factor AST-OPC direct-contact co-culture, found that significantly...
Abstract Background The cotton leafworm, Spodoptera littoralis , is a highly polyphagous pest of many cultivated plants and crops in Africa Europe. genome this will help us to further understand the molecular mechanisms polyphagy. Results Herein, high-quality S. was obtained by Pacific Bioscience (PacBio) sequencing. assembled size 436.55 Mb with scaffold N50 6.09 Mb, consisting 17,207 annotated protein-coding genes. Phylogenetic analysis shows that its sibling species litura diverged about...
Introduction: The development of insecticide resistance in Spodoptera frugiperda populations is a serious threat to the crop industry. Given spread invasive resistant populations, prospective monitoring should be accelerated, and diagnostic tools for rapid accurate assessments essential. Methods: First, discriminating dose time kit were determined by glass vial method based on susceptible strain. Then, pests that collected from field used determine their susceptibility seven insecticides...
The yellow peach moth, Conogethes punctiferalis, is a highly polyphagous pest widespread in eastern and southern Asia. It demonstrates unique ability to adapt rotten host fruits displays resistance pathogenic microorganisms, including fungi. However, the lack of available genomic resources presents challenge comprehensively understanding evolution its innate immune genes. Here, we report high-quality chromosome-level reference genome for C. punctiferalis utilizing PacBio HiFi sequencing Hi-C...
Understanding the genetic basis of adaptive evolution following habitat expansion can have important implications for pest management. The pink rice borer (PRB), Sesamia inferens (Walker), is a destructive that was historically restricted to regions south 34° N latitude in China. However, with changes global climate and farming practices, distribution this moth has progressively expanded, encompassing most North Here, 3 highly differentiated subpopulations were discovered using high-quality...
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Dysregulated glucose metabolism in the brain is considered to be one of key causes Alzheimer's disease (AD). Abnormal uptake AD tightly associated with decreased levels transporter 1 (GLUT1) and GLUT3 brain, but underlying mechanisms remain unclear.We aimed explore cause mechanism impaired AD.N2a/WT N2a/APP695swe cells were cultured vitro, cellular ATP content, as well expression GLUT1, GLUT3, PI3K/Akt pathway members, detected. Intracellular reactive oxygen species (ROS) detected by flow...
This study presents a comprehensive morphological comparison along with molecular phylogeny of the genus Gloydius based on five mitochondrial genes (12S, 16S, COI, cytb, and ND4). The specimens collected from Jiuzhaigou National Nature Reserve are shown to be new species, Gloydiuslateralissp. nov. Zhang, Shi, Jiang & Shi combination accounts. G.lateralissp. differs other congeneric species by series diagnostic characteristics forms strongly supported monophyletic group. is phylogenetically...
We determined the complete mitochondrial (mt) genome of Rhacophorus dennysi (family Rhacophoridae).The R. mitogenome (18,052 bp) contained 37 genes and a single control region (CR) typically found in neobatrachian mtDNAs.In new mt genome, ND5 gene TLPF tRNA cluster (tRNA Thr , Leu(CUN) Pro Phe ) were located between CR 12S rRNA gene.R. rearrangements observed here could be explained by Tandem Duplication Random Loss (TDRL) model.We used twelve protein-coding newly sequenced other reported...