A5048925158- Spinal Cord Injury Research
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Retinal and Macular Surgery
- Corneal surgery and disorders
- Retinal Imaging and Analysis
- Cerebral Palsy and Movement Disorders
- Injury Epidemiology and Prevention
- Retinal Development and Disorders
- Facial Trauma and Fracture Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Nerve injury and regeneration
- Ocular Disorders and Treatments
- Pain Mechanisms and Treatments
- Neonatal and fetal brain pathology
- Spinal Dysraphism and Malformations
- Vascular Malformations Diagnosis and Treatment
- Nerve Injury and Rehabilitation
- Cardiovascular Health and Disease Prevention
- Electrospun Nanofibers in Biomedical Applications
- Craniofacial Disorders and Treatments
- Ocular and Laser Science Research
- Neurogenetic and Muscular Disorders Research
- Atherosclerosis and Cardiovascular Diseases
- Periodontal Regeneration and Treatments
Beihang University
2015-2025
Beijing Advanced Sciences and Innovation Center
2018-2020
International Collaboration On Repair Discoveries
2015-2019
University of British Columbia
2012-2019
University of Southern California
2008-2018
University of Leeds
2017
University of Minnesota
2011-2013
Doheny Eye Institute
2013
Virginia Tech
2012
Duke University
2012
This study examines the elastic properties of human posterior retina, choroid, and sclera. Twenty-four eyes from 30- to 74-year-old donors were obtained an eye bank. Vertically horizontally oriented tissue strips sclera (ideally n = 12 in each group) harvested eyes. Their thicknesses estimated optically. The samples stretched at 1 mm/s 37°C saline. Stress strain mechanical tests, then transition stress, strain, toe modulus, heel modulus calculated. Statistical analysis was performed for...
The objective of this study was to compare the long-term histological and behavioral outcomes after spinal cord injury (SCI) induced by one three distinct biomechanical mechanisms: dislocation, contusion, distraction. Thirty male Sprague-Dawley rats were randomized incur a traumatic cervical SCI these clinically relevant mechanisms. injured spines surgically stabilized, motor function assessed for following 8 weeks. cords then harvested histologic analysis. Quantification white matter...
Abstract For guided bone regeneration (GBR) in clinical orthopedics, the importance of a suitable scaffold which can provide space needed for and simultaneously promotes new formation cannot be overemphasized. Due to its excellent biocompatibility, mechanical strength, similarity structure composition natural bone, mineralized collagen-based scaffolds have been increasingly considered as promising GBR scaffolds. Herein, we propose novel method fabricate an in-situ homogeneous (IMHCS) with...
We examine the thickness and mechanical properties of porcine posterior retina, choroid, sclera in different environments surface directions. Vertical horizontal samples were surgically obtained. Uniaxial experiments performed room-temperature air, saline, body-temperature saline. Sample thicknesses estimated optically. Thickness all layers was found to vary significantly among samples; standard deviation mean 24, 19, 19% for sclera, respectively. Transition stresses heel moduli consistently...
Retrospective study.To describe the epidemiology and clinical outcomes of pediatric patients with spinal cord injury (SCI) without radiographic abnormality (SCIWORA) in mainland China for first time.SCIWORA is a syndrome that often occurs children mainly due to unique biomechanics spine. Although there have been numerous retrospective studies on SCIWORA, has more SCI than anywhere else, SCIWORA not described any study.Review all cases at Beijing Children's Hospital between July 2007 December...
Quantifying axons and myelin is essential for understanding spinal cord injury (SCI) mechanisms developing targeted therapies. This study proposes validates an automated method to measure myelin, applied compare contusion, dislocation, distraction SCIs in a rat model. Spinal cords were processed stained neurofilament, tubulin, basic protein, with histology images segmented into dorsal, lateral, ventral white matter regions. Custom MATLAB scripts identified through brightness-based object...
There is an increasing need to understand the mechanical properties of human orbital fat and its encapsulating connective tissue (OFCT), but such knowledge not available in current literature. The purpose present study examine OFCT. From 5 pairs 76- 92-year-old Caucasian eyes 33 5- 7-month-old porcine eyes, 11 OFCT samples were dissected at posterior pole or adjacent vertical, horizontal, radial directions. Sample dimensions fixed measured. Tensile tests performed on body-temperature saline....
Purpose: To evaluate retinal damage as the result of craniomaxillofacial trauma and explain its pathogenic mechanism using finite element (FE) simulation. Methods: Computed tomography (CT) images an adult man were obtained to construct a FE skull model. A skin model was built cover outer surface previously validated right eye symmetrically copied create left model, both models assembled An orbital fat developed fill space between Simulations ball-shaped object striking frontal bone, temporal...
This study examines and compares the walking function in contusion distraction spinal cord injury (SCI) mechanisms. Moderate SCIs were surgically induced between C5 C6 Sprague-Dawley male rats. The CatWalk system was used to perform gait analysis of walkway walking. ladder rung test quantify skilled locomotor movements It found that inter-paw coordination, paw support, front kinematics, hind significantly different before after distraction. Step sequence duration, diagonal forelimb...
We previously observed that the stiffness of porcine retina was significantly higher when deforming at room temperature than body temperature. The present study further investigates this phenomenon by examining mechanical properties in saline lower temperature.Tensile testing performed on a total 15 retinal strips dissected from pig eyes. Equal amount dissection were tested 37.0 ± 0.3°C, 26.1 0.1°C, and 7.8 1.2°C. Their transition modulus, stress, strain measured for statistical analysis.The...
This study proposes and validates an automated method for counting neurons in spinal cord injury (SCI) then uses it to examine compare the surviving cells common types of SCI mechanisms. Moderate contusion, dislocation, distraction SCIs were surgically induced Sprague Dawley male rats (n = 6 each type injury). Their cords harvested 8 weeks post with 5 normal weight-matched rats. The cut, stained anti-NeuN antibody fluorescent Nissl, imaged dorsal ventral horns at various distances epicenter....
The purpose of this study is to measure, characterize, and compare the viscoelastic properties posterior eye advanced dry age-related macular degeneration (AMD) patients, age-matched normal subjects, pigs (3 groups). Ten horizontal ten vertical strips macula retina underneath choroid sclera were obtained for each group, respectively. They examined by incremental stress-relaxation cycles in body-temperature saline. Mechanical response was characterized quasi-linear model. All tissues shown be...
This study investigated the pathogenesis of age-related macular degeneration (AMD) using histological methods that are commonly used for atherosclerotic vascular disease (ASVD). 1 normal, 3 early dry AMD, and late AMD eyes were obtained from Lions Eye Bank Oregon systematically dissected. They stained with hematoxylin eosin, Oil red O, Masson, Elastica van Gieson, Alizarin red, Prussian blue. Additionally, normal immunostained a-smooth muscle actin, CD45, CD68 Nile DAPI. Correlations found...