A5078353490- Congenital heart defects research
- MicroRNA in disease regulation
- Liver Diseases and Immunity
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related molecular mechanisms research
- Coronary Artery Anomalies
Babraham Institute
2019-2020
Cholangiocarcinoma (CCA) results from the malignant transformation of cholangiocytes. Primary sclerosing cholangitis (PSC) and primary biliary (PBC) are chronic diseases in which cholangiocytes primarily damaged. Although PSC is an inflammatory condition predisposing to CCA, CCA almost never found autoimmune context PBC. Here, we hypothesized that PBC might favor immunosurveillance. In preclinical murine models challenged with syngeneic (but not PSC) reduced frequency development delayed...
The murine developing epicardium heterogeneously expresses the transcription factors TCF21 and WT1. Here, we show that this cell heterogeneity is conserved in human epicardium, regulated by BNC1 associated with fate function. Single RNA sequencing of derived from pluripotent stem cells (hPSC-epi) revealed distinct epicardial subpopulations are defined high levels expression for or TCF21. WT1