Background and Purpose— Most acute ischemic stroke patients arrive after the 3-hour time window for recombinant tissue plasminogen activator (rtPA) administration. The Desmoteplase In Acute Ischemic Stroke trial (DIAS) was a dose-finding randomized designed to evaluate safety efficacy of intravenous desmoteplase, highly fibrin-specific nonneurotoxic thrombolytic agent, administered within 3 9 hours onset in with perfusion/diffusion mismatch on MRI. Methods— DIAS placebo-controlled,...

Object Current standard of care for patients with severe traumatic brain injury (TBI) is prophylactic treatment phenytoin 7 days to decrease the risk early posttraumatic seizures. Phenytoin alters drug metabolism, induces fever, and requires therapeutic-level monitoring. Alternatively, levetiracetam (Keppra) does not require serum monitoring or have significant pharmacokinetic interactions. In current study, authors compare EEG findings in receiving those monotherapy seizure prophylaxis...

Many real-world optimization problems have more than three objectives, which has triggered increasing research interest in developing efficient and effective evolutionary algorithms for solving many-objective problems. However, most only been evaluated on benchmark test functions few applied to To move a step forward, this paper presents case study of hybrid electric vehicle controller design problem using state-of-the-art algorithms, namely, decomposition based algorithm (MOEA/D),...

Background: Recent meta-analyses of randomized controlled trials in homeopathy have suggested that is more than a placebo response. Objective: Comparison the effectiveness primary care with conventional medicine for three commonly encountered clinical conditions. Design: An international multicenter, prospective, observational study real world medical setting comparing medicine. Participants: Thirty (30) investigators licenses at six sites four countries enrolled 500 consecutive patients...

Research Article| September 01, 2009 Real-time Performance of the Virtual Seismologist Earthquake Early Warning Algorithm in Southern California Georgia Cua; Cua Swiss Seismological Service ETH Zurich Switzerland georgia.cua@sed.ethz.ch (G. C.) 1Swiss Service, Zurich, Search for other works by this author on: GSW Google Scholar Michael Fischer; Fischer Thomas Heaton; Heaton 2California Institute Technology, Pasadena, California, U.S.A. Stefan Wiemer Letters (2009) 80 (5): 740–747....

Abstract Background The aim of this study was to assess the effectiveness homeopathy compared conventional treatment in acute respiratory and ear complaints a primary care setting. Methods designed as an international, multi-centre, comparative cohort non-randomised design. Patients, presenting themselves with at least one chief complaint: (≤ 7 days) runny nose, sore throat, pain, sinus pain or cough, were recruited 57 practices Austria (8), Germany Netherlands (7), Russia (6), Spain Ukraine...

Modern machine learning techniques have shown tremendous potential, especially for object detection on camera images. For this reason, they are also used to enable safety-critical automated processes such as autonomous drone flights. We present a study Detect and Avoid, safety critical function drones that detects air traffic during flights reasons. An ill-posed problem is the generation of good large data sets, since itself corner case. Most models suffer from limited ground truth in raw...

Human experience with technology has shifted from technological contexts requiring occasional intervention by a fraction of people mostly in command technologies, to that require constant ongoing participation most complete tasks. We examine the current state `mixed-use' new technologies integration legacy systems, and whether human assistance required tasks processes could function as training ground for future smart or increasing `co-dependence with' `training of' algorithmic enhancing...

article Free AccessReliable communication over unreliable channels Authors: Yehuda Afek Tel Aviv Univ., Aviv, Israel IsraelView Profile , Hagit Attiya Technion–Israel Institute of Technology, Haifa, Alan Fekete Univ. Sydney, Australia AustraliaView Michael Fischer Yale New Haven, CT CTView Nancy Lynch Massachusetts Cambridge CambridgeView Yishay Mansour Dai-Wei Wang Academia Sinica, Taipei, Taiwan TaiwanView Lenore Zuck Authors Info & Claims Journal the ACMVolume 41Issue 6Nov. 1994 pp...

Background An increase in mean platelet volume has been reported to be associated with arterial thrombosis and myocardial infarction. A larger regarded as an independent risk factor for recurrent We therefore investigated whether it is also increased patients coronary heart disease examined a few days before cardiac surgery. Methods Four hundred twenty-six who were waiting surgery 125 healthy individuals included the study. Mean other parameters obtained from routine blood count procedure...

This qualitative research examines gender differences in offenders’ability to negotiate a positive identity once the pejorative labels of criminal, prostitute, drug dealer, and incompetent parents have been imputed onto them. In-depth semi-structured focused interviews were conducted with purposeful information-rich sample eight male female offenders. Content analysis reveals that males much more adept than offenders at juggling conventional street norms justify and/or resist stigmatizing...

Preliminary evidence suggests local brain tissue oxygenation (PbtO2) values of ≤15 mm Hg following severe traumatic injury (TBI) represent hypoxia. Accordingly, many neurotrauma units attempt to maintain PbtO2 ≥20 avoid This study tested the impact a short (2 h) trial normobaric hyperoxia on measures oxidative stress. We hypothesized this treatment would positively affect cerebral but negatively cellular environment via stress mechanisms. Cerebrospinal fluid (CSF) was serially assessed in 11...

This study examined the extent to which a multiethnic sample of 900 Israeli high school students supported date-rape and victim-blaming attitudes predictors such support. Findings indicate wide support for stereotypes justifying sexual coercion by time location date, victim’s behavior, minimization seriousness date rape. A regression analysis indicates that students’ gender age are strongest rape-tolerant attitudes. Socioeconomic status religious orientation explain small proportion variance...

Freight transportation is a critical element of the system and economy Los Angeles County, California. links large consumer market, major manufacturing industry sector, international trade network to rest United States world. As agency responsible for planning programming in County Metropolitan Transportation Authority needs comprehensive tools understanding demands freight sector effects investment on this sector. A project was undertaken design comprehensive, innovative, multimodal...

Eleven female drug-court participants looked at current and past experiences to assess their program envision future innovations. From these women's perspective, the strongest component of drug court was being surrounded by staff dedicated progress recovery. Graduated supervision accurate testing were appreciated rather than resented when not humiliated treated with respect. Wraparound services, resources, referral; treatment facilities that accepted children; individualized plans therapy...

Based on in-depth qualitative interviews, this article gives the opportunity to 145 sixth graders tell, in their own words, how they felt and reacted when verbally emotionally abused by classmates. Content analysis of interviews revealed gender differences students’ reactions verbal aggression. Another interesting finding was differentiation between aggressive messages meant be for fun from those that were not so based (1) contextual cues, (2) other peers’ reaction, (3) malleability personal...

We consider some possible broad changes that may impact society as a whole result of widespread integration full-spectrum deployed pervasive computing technologies. Our approach considers design challenges for successfully developing and integrating technologies into culture society. This is particularly challenging, since services are most successful when transparent, invisible, overlooked, unacknowledged seemingly forgotten by the very groups embrace their usage development. suggest...