A5014331829- Cholangiocarcinoma and Gallbladder Cancer Studies
- Synthesis of Organic Compounds
- Consumer Attitudes and Food Labeling
- Free Radicals and Antioxidants
- Cancer therapeutics and mechanisms
- RNA modifications and cancer
- Agriculture Sustainability and Environmental Impact
- Cancer, Hypoxia, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Biochemical effects in animals
- Neuroendocrine Tumor Research Advances
- Seed and Plant Biochemistry
- Cancer-related molecular mechanisms research
- Advanced Breast Cancer Therapies
- melanin and skin pigmentation
Thammasat University
2024
Bangkokthonburi University
2022
Khon Kaen University
2017-2020
Lactate dehydrogenase A (LDHA), a key metabolic enzyme, plays crucial role in the final step of anaerobic glycolysis. Overexpression LDHA is observed many human malignancies association with tumor progression. The purpose this study was to investigate expression pattern during carcinogenesis, its clinico-pathological association, and evaluate prognostic value CCA patients. investigated using immunohistochemistry technique both hamster- (n=60) human-CCA tissues (n=82). Plasma LDH from healthy...
Pyruvate kinase M2 (PKM2) is an enzyme that predominantly overexpressed in various types of cancer. The role PKM2 liver fluke-associated cholangiocarcinoma (CCA) remains unclear. This study aimed to investigate the antitumor activity shikonin, a inhibitor, CCA cells.Immunohistochemistry and immunoblotting were used determine expression tissues cells. Antiproliferative effects shikonin evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, colony-formation trypan blue...
A quinoa natto protein herb product was developed as an alternative to traditional foods. The current study aimed introduce a new approach for producing from seeds enhance their bioactive properties and increase antioxidant activity. <i>Bacillus subtilis</i> subsp. chosen the fermentation strain due its widespread use in fermented Both proteins (QNPs) with herbs (QNPHs) were evaluated total soluble trichloroacetic acid-soluble peptide content. Gel electrophoresis assays conducted...
Diabetes is a major risk factor in the development and progression of several cancers including cholangiocarcinoma (CCA). However, molecular mechanism by which hyperglycemia potentiates CCA not clearly understood. Here, we showed that high glucose condition significantly increased reactive oxygen species (ROS) production promoted aggressive phenotypes cells, proliferation migration activities. Mannosidase alpha class 2a member 2 (MAN2A2), was upregulated at both mRNA protein levels glucose-...
Skin hyperpigmentation is an aesthetic problem that leads to psychosocial issues. Thus, skin whitening agents from agro- and poultry-industrial co-products are considered high economic value ingredients of interest for sustainable application. Therefore, this study aimed determine the cosmeceutical potential anserine/carnosine-rich chicken extract (ACCE) Thai native Pradu Hang Dam Mor Kor 55 (PD) meat. The chemical composition was identified quantified using HPLC-UV method. Then,...
Cholangiocarcinoma (CCA) is a highly aggressive disease. Most of CCA patients are diagnosed in an advanced stage the disease, when it unresectable and there chemoresistance, resulting poor prognosis. However, effective therapeutic regimens molecular targets for remain poor. Cyclin-dependent kinases (CDKs) key regulatory enzymes cell cycle progression. Aberrant CDK activation hallmark cancer. Dinaciclib small molecule inhibitor multiple CDKs, currently under clinical evaluation treating...