A5007214105- Ocular Oncology and Treatments
- Head and Neck Surgical Oncology
- Neonatal and fetal brain pathology
- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Neonatal Respiratory Health Research
- Cancer-related Molecular Pathways
- Infant Development and Preterm Care
- Fetal and Pediatric Neurological Disorders
- Ocular Disorders and Treatments
- Meningioma and schwannoma management
- Cancer, Hypoxia, and Metabolism
- Vascular Malformations Diagnosis and Treatment
- Inflammatory Bowel Disease
- Diagnosis and treatment of tuberculosis
- Immunodeficiency and Autoimmune Disorders
- Ear and Head Tumors
- Salivary Gland Tumors Diagnosis and Treatment
- Ocular Diseases and Behçet’s Syndrome
- Abdominal Surgery and Complications
- Head and Neck Cancer Studies
- Microwave Engineering and Waveguides
- Medical Imaging and Pathology Studies
- Nonmelanoma Skin Cancer Studies
- Polyomavirus and related diseases
University Children's Hospital Zurich
2022-2025
University of Zurich
2022-2025
Kocaeli Üniversitesi
2024
Essen University Hospital
2013-2022
University of Duisburg-Essen
2013-2021
Institut für Medizinische Informatik, Biometrie und Epidemiologie
2015
Institut Curie
2015
Abstract Objectives Cerebral magnetic resonance imaging (cMRI) at term-equivalent age (TEA) can detect brain injury (BI) associated with adverse neurological outcomes in preterm infants. This study aimed to assess BI incidences a large, consecutive cohort of infants born < 32 weeks gestation, the comparison between very (VPT, ≥ 28 + 0 gestation) and extremely (EPT, across gestation. Methods We retrospectively analyzed cMRIs TEA VPT EPT large tertiary center (2009–2018). recorded compared...
Abstract Objective Impaired cognition is a frequent complication of prematurity, closely related to patients’ outcomes. Imaging features cerebellar hemorrhages (CBH) impaired are not well studied. This study evaluated the relationship between cMRI-derived CBH characteristics and clinical risk factors for adverse cognition. Methods Our analysis threefold: (1) We included very preterm infants (2009–2018) undergoing cMRI, compared cMRI findings with without CBH. (2) In cohort, we associated...
To improve the prediction of neurodevelopmental outcome in very preterm infants, this study used combination amplitude-integrated electroencephalography (aEEG) within first 72 h life and cranial magnetic resonance imaging (MRI) at term equivalent age. A single-center cohort 38 infants born before 32 weeks gestation was subjected to both investigations. Structural measurements were performed on MRI. Multiple regression analysis identify independent factors including functional structural...
Previous studies have described a correlation between variants of the circle Willis and pathological findings, such as cerebrovascular diseases. Moreover, anatomic variations anterior cerebral artery (ACA) seem to correspond prevalence aneurysms in communicating (ACoA). The aim this study was assess patients with anatomical/morphological Willis.We retrospectively analyzed 223 who underwent angiography January 2002 December 2010 for aneurysm ACoA. Diagnostic imaging reviewed statistically...
Purpose To assess the correlation of intraocular retinoblastoma tumor size measured with magnetic resonance (MR) imaging in prediction histopathologically determined metastatic risk factors (postlaminar optic nerve invasion and massive choroidal invasion). Materials Methods The ethics committee approved this retrospective multicenter study a waiver informed consent. population included 370 consecutive patients (375 eyes) who underwent baseline MR imaging, followed by primary enucleation from...
Pineal cysts are a common incidental finding on brain MRI with resulting difficulties in differentiation between normal glands and pineal pathologies. The aim of this study was to assess the size morphology cystic gland children (0-5 years) compare findings published pineoblastoma cases.In retrospective multicenter study, 257 MR examinations (232 children, 0-5 were evaluated regarding (width, height, planimetric area, maximal cyst(s) size) morphology. We performed linear regression analysis...
Background MYCN-amplified RB1 wild-type (MYCNARB1+/+) retinoblastoma is a rare but clinically important subtype of due to its aggressive character and relative resistance typical therapeutic approaches. Because biopsy not indicated in retinoblastoma, specific MRI features might be valuable identify children with this genetic subtype. Purpose To define the phenotype MYCNARB1+/+ evaluate ability qualitative help Materials Methods In retrospective, multicenter, case-control study, scans...
Magnetic resonance colonography (MRC) is a well-accepted, noninvasive imaging modality for the depiction of inflammatory bowel disease. Diffusion-weighted (DWI) very helpful to display lesions. The aim this retrospective study was assess whether intravenous contrast needed depict lesions in magnetic if DWI available.Thirty-seven patients (23 females, 14 males; mean age, 14.6 years) underwent MRC on 1.5-T scanner (MAGNETOM Avanto; Siemens). Contrast-enhanced T1-weighted (ce-T1-w) sequences...
Differentiation between normal solid (non-cystic) pineal glands and pathologies on brain MRI is difficult. The aim of this study was to assess the size gland in children (0-5 years) compare findings with published pineoblastoma cases.We retrospectively analyzed (width, height, planimetric area) 184 non-retinoblastoma patients (73 female, 111 male) aged 0-5 years MRI. effect age gender evaluated. Linear regression analysis performed analyze relation age. Ninety-nine percent prediction...
Purpose To identify associations between magnetic resonance (MR) imaging features and gene expression in retinoblastoma. Materials Methods A retinoblastoma MR atlas was validated by using anonymized images from referral centers Essen, Germany, Paris, France. Images were 39 patients with (16 male 18 female [the sex five unknown]; age range, 5-90 months; inclusion criterion: pretreatment imaging). This used to compare genome-wide messenger RNA (mRNA) data 60 consecutive obtained 1995 2012 (35...
Preterm birth incorporates an increased risk for cerebellar developmental disorders likely contributing to motor and cognitive abnormalities. Experimental evidence of dysfunction in preterm subjects, however, is sparse. In this study, classical eyeblink conditioning was used as a marker dysfunction. Standard delay investigated 20 adults 32 preschool children born very preterm. Focal lesions were excluded based on structural magnetic resonance imaging. For comparison, equal number matched...
Background To demonstrate histopathological findings in retinoblastoma eyes enucleated after intra-arterial chemotherapy (IAC) with special emphasis on vascular toxicity and local tumour control. Methods Retrospective study a consecutive series of 23 IAC where work-up was available. Results From November 2010 to June 2019 were the attempt eye salvaging therapy using melphalan. first line treatment nine salvage 14 eyes. Doses melphalan ranged from 3 7.5 mg, whereby strict protocol...
To investigate the prevalence and magnetic resonance imaging (MRI) phenotype of retinoblastoma-associated orbital cellulitis. Additionally, this study aimed to identify postlaminar optic nerve enhancement (PLONE) patterns differentiating between inflammation tumor invasion.A monocenter cohort assessed cellulitis features on MRI in retinoblastoma patients. A multicenter case-control compared cases with controls.A consecutive patient 236 patients (311 eyes) was retrospectively investigated....
<b><i>Background:</i></b> Preterm infants are at increased risk of neurodevelopmental impairment due to the vulnerability immature brain. Early stratification is necessary for predicting outcome in period highest neuroplasticity. Several biomarkers magnetic resonance imaging (MRI) term equivalent age (TEA) have therefore been suggested. <b><i>Objective:</i></b> To assess predictive value simple brain metrics and total abnormality score (TAS) –...
<h3>Background</h3> PD-1/PD-L1 inhibitors are promising approaches for advanced Merkel cell carcinoma (MCC). Nevertheless, these bear a high risk induction of immune-related adverse events (irAEs), particularly flares preexisting autoimmune diseases. Neurological irAEs possibly underestimated and potentially fatal toxicities. Additionally, exacerbations myasthenia gravis (MG) with MG-specific-related mortality have been reported. <h3>Case presentation</h3> A 61-year-old woman history MG...
Retinoblastoma and other eye tumors in childhood are rare diseases. Many the first signs of a genetic tumor predisposition syndrome affected children carry higher risk developing cancers later life. Clinical data all with diagnosed between 2013–2018 Germany Austria were collected multicenter prospective observational study. In five years, 300 recruited into study: 287 retinoblastoma, 7 uveal melanoma, 3 ciliary body medulloepithelioma, 2 retinal astrocytoma, 1 meningioma optic nerve...
PurposeTo evaluate the effectiveness of baseline screening and follow-up with MRI to detecting trilateral retinoblastoma (TRb) assessing risk TRb development.DesignProspective multicenter cohort studyMethodsA total 607 patients from 2012 through 2022 were included followed up until 1-9-2023. At each center a neuroradiologist categorized pineal glands on scans into four groups: (A) normal, (B) cystic gland, (C) suspicious or (D) TRb. Different schedules assigned category. Categories...
Background: Detection of nodal metastasis is critical for the treatment and prognosis head neck cancer (HNC). Positron emission tomography/computed tomography (PET/CT) increasingly being used to detect cervical lymph node involvement. Aim: The purposes this study were (1) investigate diagnostic accuracy PET/CT detection in patients with HNC (2) determine effect time interval between surgery PET/CT. Methods: Fifty squamous cell carcinoma who underwent before included study. Preoperative...
Advanced localized retinoblastoma can be cured by enucleation, but extraocular spread of cells is associated with a high mortality. Risk-stratified adjuvant treatment chemotherapy and radiotherapy has been shown to reduce the risk for relapse in children histopathological factors. Data 184 patients primary enucleation were collected prospective, multicenter, observational study between 2013 2020. The clinical characteristics evaluated as factors progression-free overall survival rates...
To validate associations between MRI features and gene expression profiles in retinoblastoma, thereby evaluating the repeatability of radiogenomics retinoblastoma.