The global cell culture market is experiencing significant growth due to the rapid advancement in antibody-based and cell-based therapies. Both rely on capacity of different living factories, namely prokaryotic eukaryotic cells, plants or animals for reliable mass production. ability improve production yield important concern. Among many strategies pursued, optimizing complex nutritional requirements protein has been frequently performed via media component titration serum replacement....

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructure and mechanism in the photoreduction of aryl chlorides alkane solventsNigel J. Bunce, John P. Bergsma, Michael D. Wilma De Graaf, Yogesh Kumar, Luis RavanalCite this: Org. Chem. 1980, 45, 18, 3708–3713Publication Date (Print):August 1, 1980Publication History Published online1 May 2002Published inissue 1 August 1980https://pubs.acs.org/doi/10.1021/jo01306a033https://doi.org/10.1021/jo01306a033research-articleACS PublicationsRequest reuse...

β-Lactams are important heterocycles with diverse pharmacological profiles and have emerged as useful organic synthons.

Here we report a photoactive supramolecular assembly that is multifunctional and constructed by covalently linking four receptor molecules (cucurbit[7]uril) to porphyrin derivative with suitable linkers. While this molecular platform serves very efficiently as light-triggered broad-spectrum antibacterial agent, owing its negligible dark cytotoxicity the presence of host (CB7), it can also be utilized vehicle carry drug for combined chemo photodynamic cancer therapy.

Abstract Aromatic compounds were efficiently nitrated under facile reaction conditions by employing 69% nitric acid catalyzed transition-metal complexes such as [Co(NH3)5Cl]Cl2, [Cu(NH3)4]SO4, Mn(acac)3, [Ni(NH3)6]Cl2, [Ni(en)3]S2O3, and Hg[Co(SCN)4]. The was completed smoothly at room temperature afforded corresponding mono-nitro derivatives in quantitative yield. This new method offers efficient regioselective mononitration of aromatic compounds. Keywords: nitrationnitric...

A facile and highly diastereoselective synthesis of<italic>cis</italic>-3-(hydroxyl/bromo)methyl-1-aryl-4-(-styryl)azetidin-2-ones<italic>via</italic>copper(<sc>i</sc>) mediated Kinugasa reactions of previously unexplored functionalized α,β-unsaturated nitrones.

The reactions of butadienylketene with variety 1,4‐diazabuta‐1,3‐dienes are studied. resulted in the formation previously unknown functionalized cis butadienyl‐4‐iminomethyl‐azetidin‐2‐ones and butenylidene‐butadienyl‐[2,2′‐biazetidine]‐4,4′‐ diones. Butadienyl ketene reacts [2+2] cycloaddition fashion both iminic portion 1,4‐ diazabuta‐1,3‐dienes competitive [4+2] reaction as 4π component butadienyl 2π not observed.

A series of novel (+/-) 3-menthone semi carbazides (1-7) and thiosemicarbazides synthesized using an appropriate synthetic route characterized by thin layer chromatography spectral analysis. The anticonvulsant activity compounds was established after intraperitoneal administration in three seizure models mice which include maximal electroshock (MES), subcutaneous pentylene tetrazole (scPTZ) induced minimal neurotoxicity test. Seven exhibited protection both N(1) - (4-fluorophenyl) N(4)-...

Abstract Visible‐light triggerable, stable, organic material‐based photocatalysts that can function in alkaline media without the necessity of sacrificial agent for hydrogen production are highly sought after. Here, we report a novel supramolecular photocatalyst confers aforementioned features. This ( TPP‐4CB7 ) is synthesized through conjugation monohydroxylated cucurbit(7)uril (CB7) hosts to suitably substituted tetraphenyl porphyrin. Although by its own preforms as an efficient visible...

A chemoselective synthesis of novel 1,4-benzodiazepin-2-ones and dienyl thiazolidin-4-one carboxylates in excellent yields by ring transformation reactions functionally decorated 2-azetidin-3-thiazolidin-4-ones is reported.

Highly diastereo- and π-facially selective imino Diels–Alder cycloadditions of 3-allylideneamino-2-azetidinones having stereocentres at its α- β-positions, with symmetrical dienophiles leading to the formation biologically potent (2-oxo-4-styrylazetidin-3-yl)–pyridine hybrids have been reported.

The photocatalytic potential of chlorophyll has been investigated for the facile synthesis dihydropyrimidinones utilizing concentrated solar irradiation towards sustainable energy solutions. This, one-pot, multicomponent Biginelli reaction, which involves a photoinduced electron transfer (PET) mechanism, affords green and efficient approach transformation commercial aldehydes, β-keto ester urea into valuable 3,4-dihydropyrimidin-2(1H)-ones with wide substrate scope diversity. These improved...

Abstract The manuscript describes a straightforward and atom‐efficient method for the synthesis of α ‐alkylidene‐ β ‐lactams using sorbyl tosylate imines/1‐azadienes at high temperature (80 °C). Density functional theory calculations have shown prevalence first order kinetics in these [2+2] cycloadditions to produce mixture 3‐butadienyl‐azetidin‐2ones 3‐but‐2‐enylidene‐azetidin‐2‐ones good yields. also antimicrobial activity against E . coli, S aureus, P aeruginosa, B cereus subtilis.

Renewable concentrated solar-radiation (CSR) offered a promising en route for the development of practical, highly efficient, scalable, catalyst free and solvent-free clean process leading to synthesis functionalized benzimidazoles.Developed protocol has very good substrate scope, involves mild reaction conditions products obtained in excellent yields.Method presented observations which light alone could affect remarkable changes with more than 85% energy saving 75% less time listed organic...

ABSTRACT Vilsmeier–Haack (VH) formylation reactions with acetophenones are sluggish in acetonitrile medium even at elevated temperatures. However, millimolar concentrations of transition metal ions such as Cu(II), Ni(II), Co(II), and Cd(II) were found to exhibit efficient catalytic activity Reactions acetophenones. accelerated remarkably the presence ions. The VH followed second order kinetics afforded acetyl derivatives under kinetic conditions also irrespective nature oxychloride (POCl 3...

Abstract We report herein an efficient, straightforward and ligand free synthesis of aminopyridyl carboxylates, important building block used in pharmaceuticals agrochemicals. The C(sp 2 )‐N bond formation utilize a readily available Cu‐catalyst, NaN 3 as the amino source ethanol, corresponding ortho‐functionalized aromatic amines were synthesized good to excellent yields. This one‐pot domino methodology proceeds through Ullmann‐type coupling halopyridyl carboxylates with sodium azide...

The manuscript describes a simple, convenient and metal-free diastereoselective synthesis of 4-halo-3-aryl/alkyl-6-aryl-2,6-diazabicyclo[3.2.0]heptan-7-ones via intramolecular endo-trig haloamination 3-aminoazetidin-2-ones its facile transformations to previously unknown methyl 4-halo-3-arylaminopyrrolidine-2-carboxylates N-deprotected diazabicyclo[3.1.0]hexane-2-carboxylicacids in good yields.The such heterocyclic system is important terms the usefulness as organic synthon well their...

Vilsmeier–Haack reactions (VHR) with acetanilides afforded 2-chloro 3-formyl quinoline derivatives. The obeyed second order kinetics a first dependence on VHR as well acetanilide. Significant rate enhancements were observed when transition metal ions such Cu(II), Ni(II), Co(II), and Cd(II) used catalysts in these reactions. kinetic results ion catalyzed coupled uv-visible spectrophotometric observations substantiated the participation of mixed ligand precursors type [M(II)S(VHR)] involving...

Abstract A novel, efficient and one‐pot multicomponent copper‐catalyzed amination of N ‐pyridyl imines is described. This, one‐pot, reaction, in which imine acts as a directing group by chelating to the metal core, affords domino approach for transformation commercial pyridinamines, aldehydes azide into valuable imidazo[4, 5‐b]pyridines with wide substrate extent diversity.

Cancer is one of the most common, devastating class disease affecting millions people causing large number death every year. It therefore considered to be second leading cause in developing countries next cardiovascular diseases. Recent molecular studies have focussed on targeted gene for cancer i.e. DNA topoisomerase II (DNA TOP2), an enzyme that controls and alters topological states during transcription. TOP2 also a target known anticancer drugs like etoposide, doxorubicin, daunorubicin,...