Building blocks of life show well-defined chiral symmetry which has a direct influence on their properties and role in Nature. Chiral molecules are typically characterized by optical techniques such as circular dichroism (CD) where they exhibit signatures the ultraviolet frequency region. Plasmonic nanostructures have potential to enhance sensitivity detection translate molecular chirality visible spectral range. Despite recent progress, date, it remains unclear plasmonic sensors should...

Chiro-sensitive molecular detection is highly relevant as many biochemical compounds, the building blocks of life, are chiral. Optical chirality conventionally detected through circular dichroism (CD) in UV range, where molecules naturally absorb. Recently, plasmonics has been proposed a way to boost otherwise very weak CD signal and translate it visible/NIR technology friendlier. Here, we explore how dielectric nanoresonators can contribute efficiently differentiate enantiomers. We study...

The need for point-of-care devices able to detect diseases early and monitor their status, out of a lab environment, has stimulated the development compact biosensing configurations. Whereas localized surface plasmon resonance (LSPR) sensing integrated into state-of-the-art microfluidic chip stands as promising approach meet this demand, its implementation an operating platform capable quantitatively detecting set molecular biomarkers in unknown biological sample is only infancy. Here, we...

Abstract Using light to manipulate fluids has been a long-sought-after goal for lab-on-a-chip applications address the size mismatch between bulky external fluid controllers and microfluidic devices. Yet, this remained elusive due complexity of thermally driven dynamic phenomena, lack approaches that allow comprehensive multiscale multiparameter studies. Here, we report an innovative optofluidic platform fulfills need by combining digital holographic microscopy with state-of-the-art...

Label-free detection of multiple analytes in a high-throughput fashion has been one the long-sought goals biosensing applications. Yet, for all-optical approaches, interfacing state-of-the-art label-free techniques with microfluidics tools that can process small volumes sample high throughput, and surface chemistry grants analyte specificity, poses critical challenge to date. Here, we introduce an optofluidic platform brings together digital holography PDMS by using supported lipid bilayers...

Biosensing based on optical micro- and nanoresonators integrated in a microfluidic environment is promising approach to lab-on-a-chip platforms capable of detecting low concentrations analytes from small sample volumes. While sensitivity has reached the single molecule level, practice, applicability real-life settings limited by Brownian diffusion analyte sensor surface, which dictates total duration sensing assay. Here, we use electrothermoplasmonic (ETP) effect overcome this limit through...

Fluorescence microscopes can record the dynamics of living cells with high spatio-temporal resolution in a single plane. However, monitoring rapid and dim fluorescence fluctuations, e.g induced by neuronal activity brain, remains challenging for 3D-distributed emitters due to out-of-focus background, restricted photon budget, speed limit conventional scanning systems. Here, we introduce Thermally Adaptive Surface strategy, capable simultaneously recording, at camera framerate, objects. This...

<title>Abstract</title> Fluorescence microscopes can capture the dynamics of living cells with high spatio-temporal resolution in a single plane. However, monitoring rapid and dim fluorescence fluctuations, e.g. induced by neuronal activity brain, remains challenging for 3D-distributed emitters due to out-of-focus background, restricted photon budget, speed limit conventional scanning systems. Here, we introduce Thermally Adaptive Surface strategy, allowing parallel imaging objects at speeds...

We demonstrate that a set of microfabricated electrodes can be coupled to commercial optical tweezers device, implementing hybrid electro-optical platform with multiple functionalities for the manipulation micro-/nanoparticles in suspension. show scheme allows enhanced capabilities, including dynamics, controlled accumulation dielectrophoretic trap from tweezers, selectivity, and video tracking individual trajectories trapped particles. This creates opportunities novel studies statistical...

As miniaturization becomes a growing trend in optical systems, the ability to precisely manipulate wavefronts within micrometric pupils crucial. Extensive efforts develop integrated micro-optics primarily led tunable microlenses. Among these approaches,

The extraordinary sensitivity of single-photon avalanche diodes (SPADs) makes these devices the ideal option for vision systems aimed at low-light applications. Nevertheless, there exist large dark count rate and photon detection probability non-uniformities, which reduce dynamic range detector. As a result, capability to create image contrast is severely damaged or even lost. This paper presents implementation correction algorithm compensate mentioned non-uniformities thus extend generated...

Shipboard infrared search and track (IRST) systems can detect sea-skimming anti-ship missiles at long ranges. Since IRST cannot measure range line-of-sight velocity, they have difficulty distinguishing from slowly moving false targets clutter. In a joint Army-Navy program, the Army Research Laboratory (ARL) is developing chirped amplitude modulation ladar to provide velocity measurements for tracking of handed over it by distributed aperture system (DAS-IRST) under development Naval (NRL)...

Label-free detecting multiple analytes in a high-throughput fashion has been one of the long-sought goals biosensing applications. Yet, for all-optical approaches, interfacing state-of-the-art label-free techniques with microfluidics tools that can process small volumes sample high throughput, and surface chemistry grants analyte specificity, poses critical challenge to date. Here, we introduce an optofluidic platform brings together digital holography PDMS by using supported lipid bilayers...

We recently proposed a new wavefront shaping concept, coined as Smartlens, in which the phase of transmitted light is shaped by engineering temperature landscape thermo-optical material. Individually or arrays, these microscale devices can generate complex functions based on either pure, combination of, Zernike polynomials, including lenses electrically-tuneable aberration correctors. will see how this concept could complement existing optical toolbox offering low-chromatic-aberration,...

Abstract Phase change materials (PCM) have greatly contributed to optics with applications ranging from rewritable memories smart windows. This is possible thanks the variation in optical properties that PCMs undergo upon thermally‐induced phase change. However, this behavior accompanied by a loss of transparency one (or more) their phases, posing major limitation for transmission‐based functionalities. Here challenge addressed producing PCM‐based composites remain transparent visible...

We demonstrate that a set of microfabricated electrodes can be coupled to commercial optical tweezers device, implementing hybrid electro-optical trap with multiple functionalities manipulate micro/nanoparticles in suspension. Our design allows us simultaneously tens particles single potential well generated the low electric field region electrode arrangement, taking advantage negative dielectrophoresis. Together tweezers, we show scheme enhanced manipulation capabilities, including...

Label-free detecting multiple analytes in a high-throughput fashion has been one of the long-sought goals biosensing applications. Yet, for all-optical approaches, interfacing state-of-the-art label-free techniques with microfluidics tools that can process small volumes sample high throughput, and surface chemistry grants analyte specificity, poses critical challenge to date. Here, we introduce an optofluidic platform brings together digital holography PDMS by using supported lipid bilayers...

A new mathematical model for the study of nonlinear chaotic dynamics in a heavily doped erbium fiber laser is proposed. The takes into account excited state and saturable absorption at lasing wavelength.

We present a novel plasmonic sensor configuration that allows the discrimination of chiral molecules. The consists handed gold nanostructures gammadion shape, distributed in racemic (50/50 mixture) matrix with C4 symmetry. Its optical response enhances interaction molecules thus circular dichroism can be measured visible range. bare sensors exhibit flat CD signal, providing background-free measurements for molecular detection. have used model based on L-, D-, and mixture phenylalanine, which...