A5091701332- Animal Disease Management and Epidemiology
- Bayesian Modeling and Causal Inference
- HIV Research and Treatment
- COVID-19 epidemiological studies
- Mathematical and Theoretical Epidemiology and Ecology Models
- HIV, Drug Use, Sexual Risk
- Statistical Methods and Bayesian Inference
- Animal Behavior and Welfare Studies
- Genetic and phenotypic traits in livestock
- Microbial infections and disease research
- HIV/AIDS Research and Interventions
- Veterinary medicine and infectious diseases
- Mycobacterium research and diagnosis
- Vector-Borne Animal Diseases
- Influenza Virus Research Studies
- Intergenerational Family Dynamics and Caregiving
- Helminth infection and control
- Tuberculosis Research and Epidemiology
- HIV/AIDS drug development and treatment
- Birth, Development, and Health
- Child Nutrition and Water Access
- Health disparities and outcomes
- Viral Infections and Vectors
- Bayesian Methods and Mixture Models
- Evolution and Genetic Dynamics
University of Zurich
2011-2023
Manchester University NHS Foundation Trust
2023
Education Trust
2022
Danone Nutricia Research (Netherlands)
2020
Danone (Netherlands)
2020
Nutricia Research (Netherlands)
2020
Reckitt Benckiser (United Kingdom)
2017-2018
Office Of Health Economics
2016
Syngenta (United Kingdom)
2015
King's College Hospital
2009-2010
The structure of sexual contact networks plays a key role in the epidemiology sexually transmitted infections, and their reconstruction from interview data has provided valuable insights into spread infection. For HIV, long period infectivity made interpretation more difficult, major discrepancies have been observed between network transmission revealed by viral phylogenetics. high rate HIV evolution principle allows for detailed links virus different individuals, but often sampling too...
Summary 1. Ecological count data typically exhibit complexities such as overdispersion and zero‐inflation, are often weakly associated with a relatively large number of correlated covariates. The use an appropriate statistical model for inference is therefore essential. A common selection criteria choosing between nested models the likelihood ratio test (LRT). Widely used alternatives to LRT based on information‐theoretic metrics Akaike Information Criterion. 2. It widely believed that can...
The third variable loop (V3) of the human immunodeficiency virus type 1 (HIV-1) envelope is a principal determinant antibody neutralization and progression to AIDS. Although it undoubtedly an important target for vaccine research, extensive genetic variation in V3 remains obstacle development effective vaccine. Comparative methods that exploit abundance sequence data can detect interactions between residues rapidly evolving proteins such as HIV-1 envelope, revealing biological constraints on...
: Regression modelling is one of the most widely utilized approaches in epidemiological analyses. It provides a method identifying statistical associations, from which potential causal associations relevant to disease control may then be investigated. Multivariable regression - single dependent variable (outcome, usually disease) with multiple independent variables (predictors) has long been standard model. Generalizing multivariable multivariate all potentially statistically offers far...
SUMMARY Lyme borreliosis (LB) is the most common arthropod-borne disease of humans in Northern hemisphere. In Europe, causative agent, Borrelia burgdorferi sensu lato complex, principally vectored by Ixodes ricinus ticks. The aim this study was to identify environmental factors influencing questing I. nymph abundance and B. s.l. infection nymphs using a large-scale survey across Scotland. Ticks, host dung vegetation were surveyed at 25 woodland sites, climatic variables from Geographical...
: Epidemiological methods for estimating disease prevalence in humans and other animals the absence of a gold standard diagnostic test are well established. Despite this, reporting apparent is still practice public health studies control programmes, even though may differ greatly from true disease. Methods summarized reviewed. A computing appendix also provided which contains brief guide how to easily implement some presented using freely available software.
Abstract Purpose Pesticides are applied to agricultural fields optimise crop yield and their global use is substantial. Their consideration in life cycle assessment (LCA) affected by important inconsistencies between the emission inventory impact phases of LCA. A clear definition delineation product system model (life inventory—LCI, technosphere) natural environment assessment—LCIA, ecosphere) missing could be established via consensus building. Methods workshop held 2013 Glasgow, UK, had...
Highly pathogenic avian influenza (HPAI) virus H5N1 infects water and land fowl can infect cause mortality in mammals, including humans. However, HPAI strains are not equally virulent some have been shown to only mild symptoms experimental infections. Since most studies of the basis virulence mammals small scale, we undertook a meta-analysis available used Bayesian graphical models (BGM) increase power inference. We applied text-mining techniques identify 27 individual that experimentally...
Abstract Spidermonkey is a new component of the Datamonkey suite phylogenetic tools that provides methods for detecting coevolving sites from multiple alignment homologous nucleotide or amino acid sequences. It reconstructs substitution history by maximum likelihood-based methods, and then analyzes joint distribution events using Bayesian graphical models to identify significant associations among sites. Availability: publicly available both as web application at http://www.data-monkey.org...
An epidemiologic systems analysis of diarrhea in children Pakistan is presented. Application additive Bayesian network modeling to 2005–2006 data from the Social and Living Standards Measurement Survey reveals complexity child as a disease system. The key distinction between standard analytical approaches, such multivariable regression, analyses that latter attempt not only identify statistically associated variables but also, additionally empirically, separate these into those directly...
The addition of asparagine (N)-linked polysaccharide chains (i.e., glycans) to the gp120 and gp41 glycoproteins human immunodeficiency virus type 1 (HIV-1) envelope is not only required for correct protein folding, but also may provide protection against neutralizing antibodies as a "glycan shield." As result, strong host-specific selection frequently associated with codon positions where nonsynonymous substitutions can create or disrupt potential N-linked glycosylation sites (PNGSs)....
Owners' satisfaction with, and expectations from, their veterinarians around euthanasia, including questions on disposal of pet remains subject to animal species, clients' gender, age, family conditions, area living type veterinary clinic visited were evaluated by questionnaire. Questionnaires be filled out clients consecutively visiting the individual practices hospitals for any kind consultations. Of 2350 questionnaires distributed, 2008 returned available analysis. Owner concerning...
Government policy in England aims for the elimination of bovine tuberculosis (bTB). This includes culling European badger (Meles meles) to reduce cattle TB incidence. The rationale is based on a field trial, Randomised Badger Culling Trial (RBCT) 1998-2005, which reported substantial decrease bTB herd incidence where had been implemented, comparison untreated control areas. RBCT was undertaken because previous studies reductions badgers by culling, possible association between and cattle,...
The purpose of this study was to establish breed-specific reference intervals for haematological measurands in non-racing greyhounds. Suitability the data partitioning according sex also examined.Haematological were collected from 304 healthy greyhounds and analysed using non-parametric methods. Results compared with non-breed-specific canine greyhound obtained by other investigators.Compared intervals, results showed comparable mean upper limit higher lower erythrocyte count; values...
Endemic diseases of cattle, such as bovine viral diarrhea, have significant impact on production efficiency food animal origin with consequences for welfare and climate change reduction targets. Many modeling studies focus the local scale, examining on-farm dynamics this infectious disease. However, insight into prevalence control across a network farms ultimately requires level approach. Here, we implement understanding infection dynamics, gained through these detailed studies, to produce...