A retrospective epidemiological study of ulcerative colitis (UC) and proctitis was performed in Leicestershire from 1972-89. Potential cases were identified hospital departments pathology, endoscopy, medical records general practitioners. The county population includes more than 93,000 South Asians. There 573 UC 286 Europeans 115 29 standardised incidence Asians stable, except Sikhs whom it had increased rapidly. relative risk to 2.45. incidences during the 1980s were: 10.8/10(5)/year Hindus...

The family history of patients identified during incidence studies in Leicestershire were investigated and the prevalence comparative risks calculated; 1254 aged 15 to 80 years sent a questionnaire about their history. All cases with positive reviewed confirmed included study. In Europeans standardised Crohn9s disease was 75.8/10(5) that ulcerative colitis 90.8/10(5). among South Asians 33.2/10(5) 135/10(5). significantly greater than Hindus (chi 2 = 16, p < 0.001), while lower 27, 0.001)...

Twenty healthy subjects eating normal diets made repeated five-day stool collections, the 10 females making their collections in four to six successive weeks. In most there were striking variations transit time, measured by Hinton's method. The variability of average faecal wet and dry weight, volume, frequency defaecation was equally great, suggesting that time genuine. size individual stools varied even more, often tenfold or more. Faecal water content relatively constant. There no...

A retrospective, epidemiological community study of Crohn's disease was performed in Leicestershire from 1972 to 1989. The county population 930,000 includes 93,000 South Asians. Potential cases were identified hospital departments pathology, endoscopy and medical records, addition general practitioners. There 582 Europeans 28 incidence Asians has increased, particularly Muslims. standardized during the 1980s 2.4/10(5)/year Hindus, 3.4/10(5)/year Sikhs 5.4/10(5)/year risen significantly...

Summary Background : Bovine colostrum is a rich source of nutrients, antibodies and growth factors. Aim To examine the efficacy enemas in treatment distal colitis using randomized, double‐blind, controlled protocol. Methods Fourteen patients (eight female), with mean age 45 years (range, 16–75 years) mild to moderately severe (Powell‐Tuck scoring system), received enema (100 mL 10% solution) or placebo (albumin b.d. for 4 weeks. Both groups also mesalazine (1.6 g/day) or, if already taking...

Thoracoscopically assisted Ivor-Lewis oesophagectomy potentially combines the pulmonary advantages of transhiatal oesophageal dissection, with visibility and control permitted by thoracotomy. This study reviewed 17 patients who underwent this procedure an intrathoracic anastomosis. Five required conversion to thoracotomy, four because technical difficulties After operation 13 had radiological evidence atelectasis, six developed a left pleural effusion five clinically significant pneumonia....

Mortality among 610 people with Crohn9s disease identified in a population based study from 1972-89 was assessed. In Europeans the overall mortality not increased, standardised ratio (SMR) 71.8 (95% confidence interval (CI) 49 to 101). The SMR South Asians 0, CI 0 1590). varied site of (chi 2 (4) = 10.5, p < 0.05) and highest those duodenal jejunal involvement (SMR 210, 95% 44 621). Survival curve comparisons showed that colonic carried worse prognosis than terminal ileal (chi-2 9, 0.01)...

Malnutrition in hospital is often unrecognized. A nutrition team aims to teach simple methods of detecting malnutrition. On a single day all medical in-patients underwent nutritional assessment. Eighty-four patients (43 men), median age 71 years (range 28–97), were assessed. The most common diagnoses cardiac disease (26), stroke/dementia (12), non-malignant lung (9) and malignancy (6). weight loss more than 10% (%WL) was found 17/65 (26%) body mass index (BMI) less 19kg/m 2 13/69 (19%)....

Twelve healthy young men added bran 15 g twice daily to their diet and underwent aspiration of bile-rich duodenal contents at 0, 1, 2, 4 6 weeks. In the 6-week sample, but not earlier, there was a significant decrease in deoxycholate increase chenodeoxycholate. Bile unsaturated with cholesterol beginning remained so throughout. The delay action may be because it reduces formation colon does merely impede its absorption.

SUMMARY Background: Many guidelines exist regarding the surveillance of patients with Barrett's oesophagus. There are limited data, however, regard to whether practitioners follow these guidelines. Methods: We assessed current practice amongst members British Society Gastroenterology using a simple 11‐question anonymized survey, mailed 300 randomly selected from Handbook . Results : Two hundred and three (68%) responded, 76% considering that was worthwhile. In those who considered be...

To ascertain reasons for non-compliance with faecal occult blood tests in colorectal cancer screening programmes.A standard interview by a trained nurse of random sample those who declined screening.The Leicestershire town Market Harborough, where most the 25,000 population are served single general practice 10 partners.Altogether 4185 residents aged 51 to 70 years were invited receive free test (Haemoccult). Eighty one subjects from 351 wrote declining offer interviewed.Non-compliers...

We measured fasting serum and bile lipid concentrations at three intervals during the normal menstrual cycles of 11 healthy women not taking oral contraceptives. In nine them cholesterol saturation bile, therefore presumably risk developing gall stones, was higher days after midcycle than end menstruation. This change in preceded by a significant fall concentrations: mid-cycle triglyceride fell eight respectively. Changes composition biliary lipids cycle are due to direct effect sex hormones...

Background —Barrett’s metaplasia is a premalignant condition for which screening recommended. Aims/methods —Annual endoscopies have been performed on all subjects suitable surgery many years. To examine the benefits to patients of continuing this policy 10 years’ experience Barrett’s oesophagus was reviewed. Results —Of 29 374 over period, present in 1.4%. There an approximate equal sex distribution with majority cases being identified 50 years old. Thirty five per cent these were enter...

The treatment of achalasia by laparoscopic Heller's cardiomyotomy may combine the minimally invasive advantages pneumatic dilatation with success rate and low risk perforation conventional surgery. requirement for an antireflux procedure remains a contentious issue, as in Nine patients underwent cardiomyotomy; excellent symptomatic relief was obtained eight at follow-up between 12 21 months after operation. Four these agreed to 24-h pH monitoring showed no evidence acid reflux. One patient,...

An investigation was undertaken to discover whether a single intramuscular dose of long-acting (or mixed and crystalline) penicillin or day9s therapy with oral satisfactory treatment for lobar pneumonia. These treatments were compared standard hospital injection therapies. All the experimental regimes found be satisfactory. They provide justification treating pneumonia on an out-patient basis in order save admissions.

Colorectal cancer is the second commonest cause of death in UK. An effective national screening programme urgently required to reduce substantial morbidity and mortality from disease. The success any will depend on test detecting early Dukes's A carcinomas adenomatous polyps. Prognosis directly related tumour staging a proportion are thought arise Two methods exist--faecal occult blood testing sigmoidoscopy. Large trials faecal show that it detects more lesions than patients presenting with...

Tropical enteropathy, which may be related to tropical sprue, has been described in many developing countries including parts of Africa. The jejunal changes enteropathy are seen Rhodesians all social and racial categories. Xylose excretion, however, is socioeconomic status, but not race. Upper Africans Europeans excrete significantly more xylose than lower Africans. Vitamin B12 fat absorption normal, suggesting predominant involvement the proximal small intestine. Rhodesia similar that...