A5057649482- MicroRNA in disease regulation
- Mitochondrial Function and Pathology
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Extracellular vesicles in disease
- Diet and metabolism studies
- Metabolomics and Mass Spectrometry Studies
- Animal Virus Infections Studies
- Liver Disease Diagnosis and Treatment
- ATP Synthase and ATPases Research
- Hepatitis B Virus Studies
- Metabolism and Genetic Disorders
- Sodium Intake and Health
- Bone health and osteoporosis research
- Obesity, Physical Activity, Diet
- Nutritional Studies and Diet
- DNA Repair Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiovascular Disease and Adiposity
- Vitamin C and Antioxidants Research
- Peroxisome Proliferator-Activated Receptors
- RNA modifications and cancer
- Vitamin D Research Studies
- Chronic Kidney Disease and Diabetes
- COVID-19 epidemiological studies
Southern Medical University Shenzhen Hospital
2017-2025
University of Hong Kong
2021
University of Hong Kong - Shenzhen Hospital
2021
Wenzhou Medical University
2011-2016
Abstract Background Qualitative and quantitative changes in human mitochondrial DNA (mtDNA) have been implicated various cancer types. A 4,977 bp deletion the major arch of genome is one most common mutations associated with a variety diseases aging. Methods We conducted comprehensive study on clinical features mtDNA 104 colorectal patients Wenzhou area China. In particular, using real time PCR method, we analyzed content tumor tissues paired non-tumor areas from these patients. Results...
Purpose This study aimed to explore the characteristics of intestinal microflora polymorphism in postmenopausal women, and determine pathophysiological changes gene flora bone metabolism osteoporosis (PMOP) patients.
Emerging evidence suggests that atherosclerosis, one of the leading phenotypes cardiovascular diseases, is a chronic inflammatory disease. During atherosclerotic process, immune cells play critical roles in vascular inflammation and plaque formation. Meanwhile, gastrointestinal disorder considered risk factor mediating process. The present study aimed to utilize sivelestat, selective inhibitor neutrophil elastase, investigate its pharmacological benefits on atherosclerosis disclose...
Emerging evidence suggests that microRNAs (miRNAs) are essential for metabolic haemostasis of liver tissues. Among them, miR-33a is supposed to modulate the cholesterol export and fatty acid oxidation, but whether involves in process disease unclear. To disclose hypothesis, we utilized mimic antisense explore their effects primary hepatocytes or high-fat diet (HFD)-fed mice. Treatment with palmitic (PA) HFD significantly increased expression In hepatocytes, decreased mitochondrial function,...
There is a big difference in the expression of miRNAs plasma exosomes patients with HBV infection. This study aims to analyze four molecular markers peripheral blood evaluate their potential diagnostic values infection.A total 55 cases chronic hepatitis B were Experimental Group 1; 49 carriers 2, and 46 healthy control group. The RNA exosome was used specificity sensitivity draw ROC curves.There significant miRNA-1246, miRNA-150-5p, miRNA-5787, miRNA-8069 down-regulated by 1 2 Control Group,...
To investigate the impact of microecological preparation combined with modified low-carbon diet on glucolipid metabolism and cardiovascular complication in obese patients. From August 2017 to July 2020, 66 patients were recruited, administrated an (group A) or without (Group B) microecology a balanced control group C) for 6 months. Meanwhile, 20 volunteers recruited as healthy D). After 6-month intervention, subjects A B showed significant improvement body liver fat mass, reduction serum...