A5100713742- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Zoonotic diseases and public health
- Medical Imaging and Analysis
- Pelvic floor disorders treatments
- Congenital Heart Disease Studies
- Anorectal Disease Treatments and Outcomes
- Colorectal Cancer Surgical Treatments
- Receptor Mechanisms and Signaling
- Gastric Cancer Management and Outcomes
- Musculoskeletal pain and rehabilitation
- Respiratory Support and Mechanisms
- Prostate Cancer Treatment and Research
- Glaucoma and retinal disorders
- Biochemical effects in animals
- Cancer, Stress, Anesthesia, and Immune Response
- Metabolism, Diabetes, and Cancer
- Blood groups and transfusion
- Scoliosis diagnosis and treatment
- Neuroscience and Neuropharmacology Research
- Estrogen and related hormone effects
- CNS Lymphoma Diagnosis and Treatment
- Cardiac and Coronary Surgery Techniques
- Erythrocyte Function and Pathophysiology
- Cervical and Thoracic Myelopathy
Taizhou People's Hospital
2025
Nantong University
2025
Nanjing Medical University
2025
Third People's Hospital of Huzhou
2025
Huzhou University
2025
Hebei Medical University
2024
Second Hospital of Hebei Medical University
2024
Jinshan Hospital of Fudan University
2012-2023
National Health and Family Planning Commission
2018-2022
Guangdong Academy of Agricultural Sciences
2018-2022
Transient transfection studies have shown that the probasin (PB) promoter confers androgen selectivity over other steroid hormones, and transgenic animal demonstrated PB will target androgen, but not glucocorticoid, regulation in a prostate-specific manner. Previous promoters either targeted low levels of transgene expression or became too large to be conveniently used. The goal was design would small, yet high expression. Thus, composite (ARR2PB) coupled bacterial chloramphenicol...
Previous studies have demonstrated that statins improve neurological outcome and promote neuro-vascular recovery after ICH. This study is designed to examine whether simvastatin atorvastatin affect levels of growth factors activate the Akt signaling pathway during phase intracerebral hemorrhage (ICH) in rats. Sixty (60) male Wistar rats were subjected ICH by stereotactic injecttion 100 μL autologous blood into striatum treated with or without atorvastatin. Neurological functional was...
Transplantation of bone-marrow derived stem/progenitor cells has an established therapeutic effect on cardiac muscle repair after injury. However, the exact mechanism that underlies this phenomenon is not completely understood.Here we transplanted mesenchymal stem (MSCs), a major population from cells, and studied its effects injury.MSCs transplantation significantly improved The grafted MSCs did differentiate into themselves, but appeared to induce neovascularization in injured heart. In...
Aging is an inevitable physiological challenge occurring in organisms over time, and also the most important risk factor of neurodegenerative diseases. In this study, we observed cellular molecular changes different age mice LPS-induced Parkinson disease (PD) model. The results showed that behavioral performance dopaminergic (DA) neurons were declined, accompanied by increased expression pro-inflammatory factors (TLR2, p-NF-kB-p65, IL-1β TNF-α), as well pro-oxidative stress gp91phox aged...
Accumulating evidences supported that knock-down of DHCR24 is linked to the pathological risk factors AD, suggesting a potential role in AD pathogenesis. However, molecular mechanism link between and tauopathy remains unknown. Here, order elucidate relationship tauopathy, we will focus on effect tau hyperphosphorylation at some toxic sites. In present study, found significantly lead sites Thr181, Ser199, Thr231, Ser262, Ser396. Moreover, also increase accumulation p62 protein, simultaneously...
Abstract BACKGROUND The androgen‐regulated probasin (PB) promoter has been used extensively to target transgenes the prostate in transgenic mice; however, limited data exist on mechanism that dictates prostate‐specific gene expression. Tissue‐specific expression involves synergistic effects among transcription factors associated a complex bound cis ‐acting DNA elements. METHODS Using comprehensive linker scan mutagenesis, enzyme mobility shift and supershift assays, chromatin...
Background Transcatheter aortic valve implantation (TAVI) has emerged as the treatment choice for non-operable patients with severe symptomatic stenosis (AS) and may be a good alternative to surgery those at very high or prohibitive surgical risk. We performed meta-analysis evaluate comparative benefits of TAVI versus replacement (SAVR) in AS. Methods A comprehensive literature search PubMed, Embase, ScienceDirect Cochrane Central Register Controlled trials was performed, randomized well...
A transcriptional expression assessment of human samples.To evaluate 12 new candidate nucleus pulposus (NP) markers in degenerative disc disease a Chinese population.Disc degeneration is major contributor low back pain. However, no specific and reliable NP are available.Specimens were collected from 81 patients grouped into the degenerated group (undergoing discectomy fusion with significant signs degeneration) trauma control anterior vertebral body excision without degeneration). Lumbar...
The effects of four elicitors, including 100 μmol/l MeJA (methyl jasmonate), 40 μl/l hydrogen peroxide (30%, w/w), 80 mg/l SA (salicylic acid) and 0.4 g/l F3 (fungal elicitor), on suspension cultures Taxus cuspidata were studied. After addition the above enzyme activity 10-DBAT (10-deacetylbaccatin III-10-O-acetyltransferase) was induced reached its maximum 5.47, 0.97, 3.30 6.82 U, respectively. elicitation, concentrations cytochrome P450 monooxygenase also to values 0.069, 0.336, 0.321...
Abstract Patent ductus arteriosus is the third most common congenital heart disease and resulted from persistence of ductal patency after birth. Ductus closure involves functional structural remodeling, controlled by many factors. The changes in plasma protein levels associated with PDA are not known. Here we for first time demonstrate six key differential proteins human patent patients using proteomic technology present a model to illustrate constriction arteriosus. Differentially expressed...
Carbon monoxide (CO) poisoning is one of the most common diseases induced by CO injury. More than a half survivors still likely to have cognitive dysfunction, which delayed encephalopathy after acute poisoning. There no other effective treatment for except hyperbaric oxygen. Hydrogen sulfide novel signal molecule central nervous system regulation and plays role neural protection in many diseases. H2S has inhibitory effects on oxidative stress apoptosis protect against damage nerve. A...