A5015983737- Chronic Myeloid Leukemia Treatments
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- RNA Research and Splicing
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Blood groups and transfusion
- Histone Deacetylase Inhibitors Research
- Protein Degradation and Inhibitors
- Bone Tissue Engineering Materials
- Autophagy in Disease and Therapy
- Hepatitis B Virus Studies
- Viral Infections and Vectors
- High Altitude and Hypoxia
- Eicosanoids and Hypertension Pharmacology
- Titanium Alloys Microstructure and Properties
- Chemokine receptors and signaling
- T-cell and B-cell Immunology
- Renal Transplantation Outcomes and Treatments
- Quinazolinone synthesis and applications
- Sulfur Compounds in Biology
- Immune Cell Function and Interaction
- Circular RNAs in diseases
- Hematopoietic Stem Cell Transplantation
- Multiple Myeloma Research and Treatments
Harbin Medical University
2017-2024
Second Affiliated Hospital of Harbin Medical University
2017-2024
Zhejiang University
2017
First Affiliated Hospital Zhejiang University
2016-2017
Small nucleolar RNA host gene 12 (SNHG12) expression is associated with multiple cancers, including renal cell carcinoma, prostate cancer, cervical nasopharyngeal colorectal and hepatocellular carcinoma. However, SNHG12 biological function unclear in diffuse large B-cell lymphoma (DLBCL).SNHG12 clinicopathological characteristics were evaluated DLBCL tissues. CCK-8 transwell assay used to analyze the vitro role of progression. The xenograft model was explore vivo growth. physical interaction...
Hydroxychloroquine (HCQ) is the only autophagy inhibitor in clinical use and it has shown great potential treating chronic myeloid leukemia (CML). By inhibiting autophagy, HCQ enhances anti-CML efficiency of chemotherapy. In present study, we demonstrated that sensitized CML cells to Vγ9Vδ2 T cell-mediated lysis. inhibited cells, but sensitizing effects were autophagy-independent. Since sensitization was not mimicked by ATG7 knockdown even occurred absence ATG7. We revealed a time-dependent...
The roles of microRNA (miRNA/miR)‑383‑5p have been reported in several malignancies, including breast cancer, gastric ovarian cancer and lung adenocarcinoma. However, its function diffuse large B‑cell lymphoma (DLBCL) remains unclear. Thus, the present study aimed to investigate role miR‑383‑5p DLCBL. Reverse transcription‑quantitative PCR analysis was performed detect expression 80 paired tissue samples from patients with DLBCL control subjects, as well related cell lines. Kaplan‑Meier...
To analyze the expression characteristics of leukemia stem cell (LSC) antigen in acute myeloid (AML) and to explore correation LSC-specific antigens with subtypes, cytogenetics clinical efficacy AML.A total 61 newly diagnosed patients AML (except M3) hospltalized Department Hematology our hopital were selected from January 2013 March 2016. The immun phenotypes Tim-3, CD96 CD123 on leucamia cells detected by direct immunofluorescenct flow cytometry. divided into positive megative groups...
Abstract Purpose Because of the dose-dependent increased risk cardiovascular events we tried to lower dose ponatinib without reducing its efficacy in treatment BCR-ABL T315I-containing CML. Combination with hydroxychloroquine can enhance efficiency and axitinib through autophagy inhibition CML cell T315I. Methods Cell viability, cycle, cellular senescence, formation clones apoptosis assay were taken test medicine. Lentiviral vectors containing shRNA was used block verify mechanism Establish...