A5053353803- Ocular Diseases and Behçet’s Syndrome
- Retinal and Optic Conditions
- Systemic Lupus Erythematosus Research
- Retinal Diseases and Treatments
- Infectious Diseases and Tuberculosis
- Ocular Surface and Contact Lens
- Sarcoidosis and Beryllium Toxicity Research
- Vasculitis and related conditions
- Cytomegalovirus and herpesvirus research
- Autoimmune Neurological Disorders and Treatments
- Corneal Surgery and Treatments
- Ocular Infections and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- HIV/AIDS Research and Interventions
- Glaucoma and retinal disorders
- HIV-related health complications and treatments
- Angiogenesis and VEGF in Cancer
- Salivary Gland Disorders and Functions
- Otitis Media and Relapsing Polychondritis
- Tuberculosis Research and Epidemiology
- Herpesvirus Infections and Treatments
- Proteoglycans and glycosaminoglycans research
- Pneumocystis jirovecii pneumonia detection and treatment
- Cellular transport and secretion
- Drug-Induced Ocular Toxicity
Erasmus MC
2016-2025
Maastricht University Medical Centre
2023
Erasmus University Rotterdam
2015-2022
Linköping University
1997
Abstract Purpose To analyse intraocular cytokine levels and prevalence of antiretinal antibodies ( ARA s) in patients with retinitis pigmentosa RP ), age‐related macular degeneration AMD glaucoma cataract, correlate the results to clinical manifestations. Methods We collected fluid samples from n = 25), 12), 28) cataract 22), serum paired fluids N 7) 10). Interleukin IL )‐1 β , ‐1ra, ‐2, ‐6, ‐6r α ‐7, ‐8, ‐10, ‐17A, ‐23, thymus‐ activation‐regulated chemokine TARC monocyte chemoattractant...
<h3>Importance</h3> New and improved diagnostic tests for sarcoidosis-associated uveitis are needed because the currently available laboratory biomarkers (eg, lysozyme angiotensin-converting enzyme [ACE]) lacking in high sensitivity specificity. <h3>Objective</h3> To compare value of soluble interleukin 2 receptor (sIL-2R) with ACE as sarcoidosis patients uveitis. <h3>Design, Setting, Participants</h3> A cross-sectional retrospective study was conducted using data collected from 249...
To determine the prevalence of serum antiretinal antibodies (ARAs) among patients with uveitis and establish their clinical relevance.This prospective study assessed presence ARAs by indirect immunofluorescence (IIF) using primate retina in 126 60 healthy controls. Clinical data were collected from medical charts included classification uveitis, cause or its association systemic disease, stage activity specific retinal features. Correlations between various characteristics analysed.The was...
Purpose Although multiple serum antiretinal autoantibodies (ARAs) have been reported in patients with paraneoplastic and non-paraneoplastic autoimmune retinopathy ((n)pAIR), not all retinal antigens involved (n)pAIR are specified. This study aims to serologically identify presumed through determination of both known unknown ARAs by autoantibody profiling. Methods An antigen suspension bead array using 188 different representing 97 ocular proteins was performed detect samples (n = 24),...
To evaluate serum B cell activating factor (BAFF) and CXCL9 as diagnostic biomarkers for ocular sarcoidosis tuberculosis (TB). We also explore their role in the stratification of patients with QuantiFERON (QFT)-positive uveitis without another identifiable cause. Eighty various entities were included: 10 sarcoidosis, 35 TB-related (including 11 confirmed (ocular TB) 24 QFT-positive unknown cause) other entities. Levels BAFF measured. Serum was higher compared to groups (area under curve...
Retinal detachment is more common among uveitis patients than in the general population. Here, we aimed to assess prevalence of rhegmatogenous retinal (RRD) a population.We retrospectively studied 851 patients, recording characteristics such as duration, anatomical location, and cause; RRD occurrence; proliferative vitreoretinopathy (PVR) at presentation; surgical approach; reattachment rate; initial final visual acuity (VA).RRD occurred 26 (3.1%; 29 affected eyes) was significantly...
Abstract Purpose Recent insights into the pathogenesis of immune‐mediated diseases proposed a new classification, which includes autoimmune and auto‐inflammatory diseases. The prevalence specific in uveitis and/or scleritis is not yet known. In this study, we examine presence systemic patients with put special emphasis on disorders by reporting their clinical manifestations visual prognosis. Methods retrospective reviewed data 1327 presenting between January 2010 July 2016 at Erasmus Medical...
Primary vitreoretinal lymphoma [(P)VRL]) is a rare malignancy of the eye localized in retina, vitreous or choroid. Here, we aim to determine value combination innovative diagnostic methods for accurate differentiation between (P)VRL and non-(P)VRL patients with suspect uveitis vitritis.Multicolour flow cytometric immunophenotyping cells samples was performed using EuroFlow small sample tube. Additionally, cytokines/chemokines growth factors were measured specimens multiplex immunoassay. Data...
Purpose To describe and compare clinical features, treatment approaches, outcomes of ocular tuberculosis (OTB) patients in the Netherlands, a low (TB)-endemic country, Indonesia, high TB-endemic country. We also aimed to identify predictors outcomes.
The vitreous proteome might provide an attractive gateway to discriminate between various uveitis aetiologies and gain novel insights into the underlying pathophysiological processes. Here, we investigated 180 proteins discover biomarkers broaden disease by comparing (1). primary vitreoretinal lymphoma ((P)VRL) versus other aetiologies, (2). sarcoid tuberculosis (TB)-associated (3). granulomatous (sarcoid TB) aetiologies.Vitreous protein levels were determined proximity extension assay in 47...
Purpose: Diabetic retinopathy (DR) is a complication of type 2 diabetes mellitus (T2DM). Lipoprotein(a) (Lp(a)) contributes to the progression DR, but how unclear. In homeostasis retinal microvasculature, myeloid-derived pro-angiogenic cells (PACs) also play pivotal role, and fail function properly in diabetic conditions. Here, we explored putative contribution Lp(a) from patients with T2DM with/without DR healthy controls on inflammation angiogenesis endothelial (RECs), PAC differentiation....
To identify the clinical characteristics and prevalence of neoplastic nonneoplastic inflammatory masquerade syndromes (IMSs) in a tertiary center determine useful diagnostic tests.A retrospective cohort study consecutive 1906 patients diagnosed with intraocular disease.Of all initially disease, we identified 116 (6%) noninflammatory causes (neoplastic IMSs 36/116; 31% 52/116; 45%). In addition, 26 (22%, 1.4% all) had drug-induced uveitis 2 (2%, 0.1% paraneoplastic uveitis. The large B-cell...
Tear fluid forms a potential source for biomarker identification, and can be minimal invasively collected via Schirmer strips. The lack of knowledge on the processing strips however complicates analysis between-study comparisons. We studied two different pre-processing methods, specifically use punches strip versus elution in buffer. filled were from 5 healthy participants, divided into halves over length strip. In either part, or eluates obtained 4 locations, first part touching eye (head)...
Scleritis is an extremely painful and potentially blinding inflammation of the sclera with unknown pathogenesis unpredictable course. To gain insight in its disease process identify biomarker candidates, we performed extensive proteomics serum tear fluid.Prospective multicenter cohort study.A total 121 patients noninfectious scleritis (of which 39 active cases), 30 healthy controls, 23 controls (uveitis rheumatoid arthritis) were enrolled Netherlands from 2020 to 2022.Serum, fluid both eyes,...
Scleritis is a severe and painful ophthalmic disorder, in which pathogenic role for collagen-directed autoimmunity was repeatedly suggested. We evaluated the presence of sclera-specific antibodies large cohort patients with non-infectious scleritis. Therefore, we prospectively collected serum samples from 121 scleritis multicenter study Netherlands. In addition, healthy (n = 39) uveitis controls 48) were included. Serum tested anti-native human type II collagen using validated enzyme-linked...
Purpose To assess the clinical relevance of pathophysiology-based biomarkers, specifically serum C1q and whole blood interferon gene signature score (IGSS), in ocular tuberculosis (OTB) diagnosis by conducting an integrative analysis presentations treatment response.
To investigate the possible role of autoimmune reactions directed against retinal tissue in central serous chorioretinopathy (CSC), by analysing presence serum antiretinal antibodies (ARAs) and establishing their clinical relevance.Sixty-three patients with CSC were included, characteristics collected. Serum samples all CSC, 101 uveitis 60 healthy donors analysed for ARAs indirect immunofluorescence. Furthermore, on Western blot. Correlations between laboratory findings features determined...