A5063423880- Blood properties and coagulation
- Platelet Disorders and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Sepsis Diagnosis and Treatment
- Antiplatelet Therapy and Cardiovascular Diseases
- Hemophilia Treatment and Research
- Clinical Laboratory Practices and Quality Control
- Bacterial Identification and Susceptibility Testing
- Venous Thromboembolism Diagnosis and Management
- Electrocatalysts for Energy Conversion
- Urinary Tract Infections Management
- Blood disorders and treatments
- Electrochemical Analysis and Applications
- Pulmonary Hypertension Research and Treatments
- Quality and Safety in Healthcare
- Heparin-Induced Thrombocytopenia and Thrombosis
- Periodontal Regeneration and Treatments
- Neonatal Respiratory Health Research
- Neuroscience of respiration and sleep
- Fuel Cells and Related Materials
- Immune Response and Inflammation
- Cell Adhesion Molecules Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Machine Learning in Healthcare
- Trauma, Hemostasis, Coagulopathy, Resuscitation
Cytovale (United States)
2023-2025
Colorado School of Mines
2018-2023
Abstract Background Sepsis is a life-threatening syndrome that requires urgent intervention to achieve optimal outcomes[1-3]. While considered the gold standard for bacteremia and sepsis diagnosis, blood cultures (BCX) require long turnaround offer low sensitivity [4], with only 18-25% of patients returning positive BCXs [5]. In this study, we compared cellular host response test BCX in performance diagnosing risk-stratifying suspected ED. Figure 1 Rate status, per Sepsis-3 definition,...
The variability in bleeding patterns among individuals with hemophilia A, who have similar factor VIII (FVIII) levels, is significant and the origins are unknown.
Sepsis, the leading cause of mortality in hospitals, currently lacks effective early diagnostics. A new cellular host response test, IntelliSep may provide an indicator immune dysregulation characterizing sepsis. The objective this study was to examine correlation between measurements performed using test and biological markers processes associated with Phorbol myristate acetate (PMA), agonist neutrophils known induce neutrophil extracellular trap (NET) formation, added whole blood healthy...
Serotonin (5-HT) contributes to the pathogenesis of experimental neonatal pulmonary hypertension (PH) associated with bronchopulmonary dysplasia (BPD). Platelets are primary source circulating 5-HT and is released upon platelet activation. Platelet transfusions mortality increased rates BPD. As BPD often complicated by PH, we tested hypothesis that platelets activated also in lungs mice bleomycin-induced PH Newborn wild-type received intraperitoneal bleomycin (3 units/kg) three times weekly...
We present the first mathematical model of flow-mediated primary hemostasis in an extravascular injury which can track process from initial deposition to occlusion. The consists a system ordinary differential equations (ODEs) that describe platelet aggregation (adhesion and cohesion), soluble-agonist-dependent activation, flow blood through injury. formation aggregates increases resistance injury, is modeled using Stokes-Brinkman equations. Data analogous experimental (microfluidic flow)...
Polymer electrolyte membrane fuel cells are on the rise as a commercial technology, although Pt catalyst utilization and stability remain challenge. N-doped carbon supports offer opportunity to improve catalyst–support interactions, but there is limited understanding of effects various nitrogen functionalities nucleation stabilization nanoparticles (NPs). This work uses series carbons with varying N chemistries NPs produced via polyol method investigate that deposited externally nucleated...
Collagen peptides are an alternative to animal derived collagens for platelet function studies under flow. The purpose of this study was examine the use collagen in polydimethylsiloxane (PDMS) devices. Three with amino acid sequences and structures that capture von Willebrand factor bind it receptors integrin α2β1 glycoprotein VI were patterned on glass, silicon, PDMS. Each these surfaces also functionalized tridecafluoro-1,1,2,2-tetrahydrooctyltrichlorosilane (FOTS). Surfaces characterized...
Introduction: Sepsis is one of the most impactful conditions facing hospitals. Emergency Department (ED) providers often base decision to initiate treatment on nonspecific signs infection. We hypothesized that a test for quantifying state immune activation may provide an early indication response therapy. In observational study, we evaluated potential prognostic capabilities serial measurement IntelliSep in adults presenting ED who were hospitalized with suspicion sepsis. Methods: The...
Hemophilia A is a bleeding disorder categorized as severe, mild, and moderate deficiencies in factor VIII (FVIII). Within these categories the variance severity significant origins unknown. The number of parameters that could modify are so numerous experimental approaches not feasible for considering all possible combinations. Consequently, we turn to mathematical model coagulation under flow act screening tool identify most likely enhance thrombin generation. We performed global sensitivity...
The variability in bleeding patterns amongst individuals with hemophilia A, which have similar factor VIII (FVIII) levels, is significant and the origins are unknown. objective of this study was to use a mathematical model flow-mediated coagulation as screening tool identify parameters that most likely enhance thrombin generation context FVIII deficiency.Using coagulation, we performed global sensitivity analysis modifiers generation; based on results from 110,000 simulations levels varied...
We present the first mathematical model of flow-mediated primary hemostasis in an extravascular injury, which can track process from initial deposition to occlusion. The consists a system ordinary differential equations (ODE) that describe platelet aggregation (adhesion and cohesion), soluble-agonist-dependent activation, flow blood through injury. formation aggregates increases resistance is modeled using Stokes-Brinkman equations. Data analogous experimental (microfluidic flow) partial...