A5050582829- Polymer Surface Interaction Studies
- Nanofabrication and Lithography Techniques
- Surface Modification and Superhydrophobicity
- Ion-surface interactions and analysis
- Diamond and Carbon-based Materials Research
- Metal and Thin Film Mechanics
- Molecular Junctions and Nanostructures
- Nanoparticle-Based Drug Delivery
- Force Microscopy Techniques and Applications
- Adhesion, Friction, and Surface Interactions
- Electrospun Nanofibers in Biomedical Applications
- Nanoparticles: synthesis and applications
- Protein Interaction Studies and Fluorescence Analysis
- Gold and Silver Nanoparticles Synthesis and Applications
- 3D Printing in Biomedical Research
- Polysaccharides Composition and Applications
- Plasma Diagnostics and Applications
- nanoparticles nucleation surface interactions
- Advanced biosensing and bioanalysis techniques
- Ga2O3 and related materials
- ZnO doping and properties
- Bone Tissue Engineering Materials
- Advanced Semiconductor Detectors and Materials
- Semiconductor materials and devices
- Carbon Nanotubes in Composites
Joint Research Centre
2015-2024
European Commission
2006-2024
Polytechnic University of Turin
2020
Joint Research Centre
2018
Art Research Centre of the Slovak Academy of Sciences
2015
Universität Ulm
2008
Biomécanique et Bioingénierie
2006
Eindhoven University of Technology
2000
University of Minnesota
1989-1993
Tecnologie Avanzate (Italy)
1991
Acute myeloid leukemia (AML) is a severe and often fatal systemic malignancy. Malignant cells are capable of escaping host immune surveillance by inactivating cytotoxic lymphoid cells. In this work we discovered fundamental molecular pathway, which includes ligand-dependent activation ectopically expressed latrophilin 1 possibly other G-protein coupled receptors leading to increased translation exocytosis the receptor Tim-3 its ligand galectin-9. This occurs in protein kinase C mTOR...
We measure the structural and stability changes of proteins at nanomolar concentration upon interaction with nanoparticles. Using synchrotron radiation circular dichroism (SRCD), we a decrease 6 °C in thermal unfolding human serum albumin silver nanoparticles while this does not happen gold. The use SRCD allows measuring critical parameters on protein-nanoparticle interactions, it will provide experimental data relative key biological for nanotoxicology.
In this work, Time of Flight Secondary Ion Mass Spectrometry (ToF-SIMS), Principal Component Analysis (PCA) and X-ray Photoelectron Spectroscopy (XPS) have been used to characterize the surface chemistry gold substrates before after functionalization with thiol-modified glucose self-assembled monolayers subsequent biochemical specific recognition maltose binding protein (MBP). The results indicate that is achieved both on flat nanoparticles thus showing potential developed system as...
The presence of thin ordered layers Si within the interface region AlAs-GaAs heterostructures is found to tune valence-band offset throughout 0.02--0.78 eV range. High-resolution x-ray-photoemission studies prepared in situ by molecular-beam epitaxy as a function substrate temperature, arsenic flux, concentration Si, and growth sequence (AlAs on GaAs versus AlAs) indicate that this tunability associated with Si-related local dipole which can be added or subtracted from intrinsic 0.40 eV.
Abstract Carbon‐based nanomaterials have attracted much interest during the last decade for biomedical applications. Multimodal imaging probes based on carbon nano‐onions (CNOs) emerged as a platform bioimaging because of their cell‐penetration properties and minimal systemic toxicity. Here, we describe covalent functionalization CNOs with fluorescein folic acid moieties both targeting cancer cells. The modified display high brightness photostability in aqueous solutions selective rapid...
Abstract The improvement of scaffold performances as cell carriers in a tissue implant is still challenge engineering. Since cells contact with firstly sense its top surface before interacting macro‐/micro‐porous structure, the insertion chemical motifs within body could improve colonization through entire structure. In this study, combinations plasma deposition and treatment processes have been employed to create gradients inside polycaprolactone porous scaffolds, whose micro‐morphology has...
In this paper a method for fabricating nanostructured polymeric surfaces with contrasted chemical functionality is presented. First, polymer film of acrylic acid (PAA) deposited by plasma enhanced vapor deposition. It covered monolayer particles in the 500 nm range. Then oxygen etching performed, providing both nanoparticles and present between masks. The process stopped before complete residual ones are removed ultrasonic bath. Chemical contrast thus created nanodomes having plateau-like...
We report the results of a VAMAS (Versailles Project on Advanced Materials and Standards) interlaboratory study measurement composition in organic depth profiling. Layered samples with known binary compositions Irganox 1010 either 1098 or Fmoc-pentafluoro-l-phenylalanine each layer were manufactured single batch distributed to more than 20 participating laboratories. The analyzed using argon cluster ion sputtering X-ray photoelectron spectroscopy (XPS) time-of-flight secondary mass...
Polystyrene Petri dishes, aminated by a plasma deposition process, were surface modified the covalent linking of two different enzymatically hairy regions (HRs) from pectin containing, for example, rhamnogalacturonan-I and xylogalacturonan structural elements. The polysaccharide preparations share same elements apple pectin, but relative amounts lengths neutral side chains present differ. Surface analysis X-ray photoelectron spectroscopy, contact angle measurement, atomic force microscope...
The silicon surface of commercial atomic force microscopy (AFM) probes loses its hydrophilicity by adsorption airborne and package-released hydrophobic organic contaminants. Cleaning the acid piranha solution or discharge plasma removes contaminants renders very hydrophilic probe surfaces. Time-of-flight secondary-ion mass spectroscopy X-ray photoelectron investigations showed that native oxide films on AFM surfaces are completely covered for as-received probes, while cleaning methods...
Abstract Summary: In this paper, we present a review of our research activity related to the use plasma deposition and etching technologies for production functional polymers (protein affinity anti‐fouling) their application fabrication chemical contrasts at micro sub micron scale. Plasma processes acrylic acid (ppAA) PEO‐like films obtain functionalized surfaces are illustrated, together with optical lithography colloidal techniques used nanoscale patterning. particular, microstructure...
A method to measure the number of proteins bound each nanoparticle and changes in protein structure is reported.
Characterisation of engineered nanomaterials (NMs) is outmost importance for the assessment potential risks arising from their extensive use. NMs display indeed a large variety physico-chemical properties that drastically affect interaction with biological systems. Among them, hydrophobicity an important property nevertheless only slightly covered by current characterisation techniques. In this work, we developed method direct NM hydrophobicity. The determination nanomaterial hydrophobic...
We report the results of a VAMAS (Versailles Project on Advanced Materials and Standards) inter-laboratory study measurement shell thickness chemistry nanoparticle coatings. Peptide-coated gold particles were supplied to laboratories in two forms: colloidal suspension pure water and; dried onto silicon wafer. Participants prepared analyzed these samples using either X-ray photoelectron spectroscopy (XPS) or low energy ion scattering (LEIS). Careful data analysis revealed some significant...
A safe UV filter may be obtained by inhibiting the photo-generation of free radicals through modification surface TiO2 nanoparticles with carbon.
Statistically designed amphiphilic copolymer coatings were deposited onto Thermanox, Si wafer, and quartz crystal microbalance (QCM) substrates via Plasma Enhanced Chemical Vapor Deposition of 1H,1H,2H,2H-perfluorodecyl acrylate diethylene glycol vinyl ether in an Inductively Excited Low Pressure reactor. characterized by Field Emission Scanning Electron Microscopy, X-ray Photoelectron Spectroscopy, Atomic Force Water Contact Angle techniques. The surface energy the can be adjusted between...