A5020851193- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Platelet Disorders and Treatments
- Ocular Infections and Treatments
- Fungal Infections and Studies
- Dermatology and Skin Diseases
- Cutaneous lymphoproliferative disorders research
- Eosinophilic Disorders and Syndromes
- Cell Adhesion Molecules Research
- Antifungal resistance and susceptibility
Rush University Medical Center
2022-2024
Princess Margaret Hospital for Children
2012
Pathwest Laboratory Medicine
2012
The University of Western Australia
2012
Introduction Inflammatory epidermolysis bullosa acquisita (EBA) is characterized by a neutrophilic response to anti-type VII collagen (COL7) antibodies resulting in the development of skin inflammation and blistering. The antibody transfer model EBA closely mirrors this phenotype. Methods To better understand changes induced neutrophils upon recruitment from peripheral blood into lesional EBA, we performed single-cell RNA-sequencing whole dissociate capture minimally perturbed characterize...
Abstract While autoantibodies in bullous pemphigoid (BP) are known to activate the innate immune response, their direct effect on keratinocytes, and contribution of BP-IgG autoantibody-dependent keratinocyte responses BP pathology is largely unknown. Herein, we performed multiplex immunoassays bulk RNA-seq primary keratinocytes treated with IgG from patients or controls. We identified a pro-inflammatory proteolytic response release several cytokines (IL-6, IL-24, TGF-β1), chemokines (CXCL16,...
Das bullöse Pemphigoid ist eine blasenbildende Autoimmunerkrankung, die durch Autoantikörper verursacht wird, auf BP180 und BP230 abzielen. Während Ablagerungen von IgG und/oder Komplement entlang der epidermalen Basalmembran typischerweise komplementvermittelte Pathogenese hindeuten, weisen mehrere neuere Erkenntnisse komplementunabhängige Wege hin, zu Gewebeschäden subepidermaler Blasenbildung beitragen. Die wesentlichen umfassen Makropinozytose IgG-BP180-Komplexen, einer Depletion...