A5101968096- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer Immunotherapy and Biomarkers
- Pediatric health and respiratory diseases
- Adrenal and Paraganglionic Tumors
- Myasthenia Gravis and Thymoma
- Retinoids in leukemia and cellular processes
- CAR-T cell therapy research
- Nitric Oxide and Endothelin Effects
- Respiratory and Cough-Related Research
- Foot and Ankle Surgery
- Vascular Malformations Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Peptidase Inhibition and Analysis
- CNS Lymphoma Diagnosis and Treatment
- Neurological disorders and treatments
- Pain Management and Treatment
- Pharmacological Effects and Assays
- Autophagy in Disease and Therapy
- Chronic Kidney Disease and Diabetes
- Hepatocellular Carcinoma Treatment and Prognosis
- Antioxidant Activity and Oxidative Stress
- Biliary and Gastrointestinal Fistulas
- Infectious Disease Case Reports and Treatments
- Vascular Anomalies and Treatments
Dalian Medical University
2024
Longgang Central Hospital
2024
Peninsula Health
2024
Shandong Provincial Hospital
2023
Shandong First Medical University
2023
Zunyi Medical University
2023
First Hospital of Jilin University
2022
Jilin University
2022
University of Science and Technology of China
2022
Qilu Hospital of Shandong University
2019-2021
Hyperglycemia induces p38 MAPK-mediated renal proximal tubular cell (RPTC) apoptosis. The current study hypothesized that alteration of the Akt signaling pathway by hyperglycemia may contribute to MAPK activation and development diabetic nephropathy. Immunoblot analysis demonstrated a hyperglycemia-induced increase in phosphorylation kidneys at 1 mo, peaking 3 dropping back baseline 6 mo. Immunohistochemical staining with anti-pAkt antisera localized tubules. Maximal was detected concomitant...
To investigate the gender difference in knowledge, attitude, and practice of COPD diagnosis treatment China.A nationwide, multicenter, cross-sectional questionnaire study was carried out to patients' understanding experience between September 2007 December 2008.Two thousand seventy-two patients were recruited from eleven centers. The final effective questionnaires those 1,698 cases, which 32% female. Women younger, had higher body mass index, more never smokers, lesser pack-years (all...
Purpose: To investigate how the changes of definition in assessment Global Initiative for Chronic Obstructive Lung Disease (GOLD) stratification 2017 lead to chronic obstructive pulmonary disease (COPD) patient clinical characteristics across categories China. Patients and methods: COPD patients from 11 medical centers China were stratified into old new groups A–D twice according GOLD 2011 comprehensive assessment. Demography compared between A–D. Results: In 1,532 patients, distribution...
Lutein has been linked with various visual performance disorders, including age-related macular degeneration (AMD). However, previous studies evaluating the association between serum lutein and risk of AMD showed results, efficacy intake in patients remains unclear.To comprehensively estimate relationship AMD, a systematic review meta-analysis was conducted by searching eligible randomized clinical trials (RCT) case-control to study on Cochrane Library, MEDLINE, Elsevier, PubMed, Web...
Despite the intriguing therapeutic prospects offered by immune checkpoint inhibitors (ICIs), immune-related adverse events (irAEs) become an increasingly important safety issue. Herein, we report a patient with locally advanced colorectal cancer (LACRC) who received anti-programmed cell death protein 1 (PD-1) (tislelizumab) therapy, then developed weakness of limbs and drooping eyelids. He experienced sequential irAEs including severe myasthenia gravis, myocarditis, rhabdomyolysis. Although...
Background: Chronic bronchitis (CB) is closely associated with the frequency and severity of chronic obstructive pulmonary disease (COPD) exacerbation. However, little known about impact CB on COPD exacerbations, severe non-severe, recovery from an Methods: We conducted a nation-wide multicenter cross-sectional survey in China between September 2007 December 2008. Eleven hospitals participated this study. Patients' demographic information, presence CB, overall numbers exacerbation leading to...
Paragangliomas, also known as chemodectomas, are rare tumors arise from chemoreceptor tissue, and most commonly locate at the bifurcation of common carotid, jugular foramen, aortic arch, retroperitoneum. Paragangliomas generally considered to be benign tumors, rarely produce local or distant metastases. Metastasis liver is extremely rare. We report case a 39-year-old woman, who had undergone resection retroperitoneal paraganglioma her hospital for 12 years. She was referred our further...
Background Primary non-dural central nervous system mucosa-associated lymphoid tissue (MALT) lymphoma is a rare indolent B-cell lymphoma, with only few reported cases worldwide. Case summary A 33-year-old man presented 5-mo history of left blepharoptosis and 4-mo right limb numbness weakness. Magnetic resonance imaging showed significantly enhanced mass in the midbrain. Subsequent positron emission tomography revealed that lesion had increased glucose uptake. stereotactic robotic biopsy...
BACKGROUND:The present study was designed to the ability of preoperative serum concentrations tumor-associated biomarkers carcinoembryonic antigen (CEA), carbohydrate 19-9 (CA19-9) and adjusted CA19-9 assess resectability advanced gallbladder cancer (GBC). MATERIAL AND METHODS:This retrospective included patients with potentially resectable stage II–IV (AJCC 8th) GBC examined at our institution between January 2012 December 2016. Receiver operating characteristic (ROC) curve analysis used...
Introduction: Immune checkpoint inhibitors (ICIs) have emerged as pivotal therapeutics for personalized cancer treatment. Programmed death protein receptor 1/ligand 1 (PD-1/PD-L1) represent the most extensively utilized immune blockade agents. Among these, pembrolizumab has gained approval advanced management. By engaging with PD-1 on T cells, orchestrates response against tumor cells; however, it is also associated a spectrum of adverse events, including an infrequent manifestation...
<title>Abstract</title> Background Brain abscesses are critical infections of the central nervous system, resulting from various pathogens. Common causes recurrent brain include immunodeficiency, chronic otitis media, sinusitis, and intracranial infection spread. Although rare, pulmonary arteriovenous fistula (PAVF) is a significant risk factor for infections, as it allows pathogens to bypass filtration directly enter systemic circulation via abnormal vascular connections. Case Presentation:...
Clinically recognizing the changes in carpal bone volumes and understanding their implications predicting osteoarthritis (OA) is crucial clinical practice This study aimed to explore age-related differences across genders, leveraging computed tomography (CT) wrist scans create 3D surface models of these bones.
Programmed cell death protein-1 (PD-1) or its ligand PD-L1 monoclonal antibodies, opening a new era of tumor immunotherapy, and they have significantly improved the overall survival many patients with advanced solid tumors. However, in addition to effectiveness, we should also pay attention adverse effects. The instructions PD-1 inhibitor camrelizumab clearly indicate that reactive cutaneous capillary endothelial proliferation (RCCEP) is most common reaction; it for immune checkpoint...
Objective To systematically evaluate the effects of respiratory muscle training by using device on rehabilitation people undergoing cardiothoracic and abdominal surgery. Methods The relevant randomized controlled trials were searched in databases CINAHL, Medline, PubMed, EBSCO, China National Knowledge Infrastructure (CNKI), Wanfang Data, VIP. The quality studies was critically appraised data extracted two reviewers independently, a meta-analysis conducted for included...