A5101011357- Chronic Obstructive Pulmonary Disease (COPD) Research
- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
- Respiratory and Cough-Related Research
- Pharmaceutical studies and practices
- Respiratory Support and Mechanisms
- Air Quality and Health Impacts
- Pharmacovigilance and Adverse Drug Reactions
- Regional Economic and Spatial Analysis
- Allergic Rhinitis and Sensitization
- Economic Zones and Regional Development
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Influenza Virus Research Studies
- Climate Change and Health Impacts
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Dermatology and Skin Diseases
- Inhalation and Respiratory Drug Delivery
- Antifungal resistance and susceptibility
- E-commerce and Technology Innovations
- Educational Technology and Assessment
- Fungal Infections and Studies
- Biosimilars and Bioanalytical Methods
- Potassium and Related Disorders
- Antimicrobial Resistance in Staphylococcus
Jinan University
2023-2025
University of Jinan
2024
Guangzhou Medical University
2006-2023
First Affiliated Hospital of Guangzhou Medical University
2013-2023
State Key Laboratory of Respiratory Disease
2006-2023
Guangzhou Regenerative Medicine and Health Guangdong Laboratory
2023
National Bureau of Statistics of China
2001
The prevalence of chronic obstructive pulmonary disease (COPD) in China is largely unknown.To obtain the COPD through a large-population, spirometry-based, cross-sectional survey COPD.Urban and rural population-based cluster samples were randomly selected from seven provinces/cities. All residents 40 years age or older clusters interviewed with standardized questionnaire revised international BOLD (Burden Obstructive Lung Diseases) study. Spirometry was performed on all eligible...
Lianhuaqingwen Capsule (LH-C) is a traditional Chinese medicine (TCM) formula used to treat respiratory tract infectious diseases in Chinese. The aim of this study was determine the antiviral activity LH-C and its immunomodulatory effects on viral infection.The vitro cytotoxicity determined by MTT Plaque reduction assays. Time course under single-cycle virus growth conditions were which stage replication blocked. effect nuclear export nucleoprotein examined using an indirect...
Background Biomass smoke is associated with the risk of chronic obstructive pulmonary disease (COPD), but few studies have elaborated approaches to reduce COPD from biomass burning. The purpose this study was determine whether improved cooking fuels and ventilation effects on function incidence COPD. Methods Findings A 9-y prospective cohort conducted among 996 eligible participants aged at least 40 y November 1, 2002, through 30, 2011, in 12 villages southern China. Interventions were...
Background: Clarithromycin is a widely used antibiotic, but its safety profile, particularly in different age groups, remains inadequately explored. Objectives: This study aims to characterize and illustrate the features of clarithromycin-related adverse events (AEs) across groups using FDA Adverse Event Reporting System (FAERS) database, providing reference for clinical detection, prevention, management AEs various groups. Design: A disproportionality analysis was performed data from FAERS...
Objective and background: Increasing evidence suggests that low‐dose theophylline has anti‐inflammatory benefits is safe in the treatment of COPD. This study aims to evaluate efficacy safety low‐dose, slow‐release oral administered over a 1‐year period patients with Methods: A randomized, double‐blind, parallel‐group, placebo‐controlled trial was carried out. In total, 110 participants COPD were randomly assigned receive (100 mg b.i.d.) or placebo for 1 year. Use medicine symptoms recorded...
Evidence supporting the association of COPD or airflow obstruction with use solid fuels is conflicting and inconsistent.To assess self-reported for cooking heating.We analysed 18,554 adults from BOLD study, who had provided acceptable post-bronchodilator spirometry measurements information on fuels. The heating was assessed by sex, within each site, using regression analysis. Estimates were stratified national income meta-analysed. We carried out similar analyses spirometric restriction,...
Background and Objective: An association between chronic obstructive pulmonary disease (COPD) low body mass index (BMI) has been well established in cross-sectional studies. However, there have few cohort studies investigating this issue. We therefore aimed to address gap. Methods: Two population-based studies, a study including 1818 subjects subsequent 4-year consisting of 759 individuals without COPD, were conducted Guangzhou, China. Every subject was 40 years old or older at the time...
Recently, the prevalence trend of pulmonary fungal infection (PFI) has rapidly increased. Changes in risk factors for, distributions underlying diseases associated with and clinical characteristics some individual PFIs have been reported past decade. However, data regarding remain uncertain. This study reports epidemiological trends over time recent years. We applied an automated natural language processing (NLP) system to extract clinically relevant information from electronic health...
Molnupiravir, an urgently approved drug during the Coronavirus Disease 2019 (COVID-19) pandemic, serves as basis for our study, which relies on Food and Drug Administration Adverse Event Reporting System (FAERS). The objective is to extract adverse event (AE) signals associated with molnupiravir from FAERS database, thereby providing a reference post-marketing monitoring of events. Specifically, we extracted individual case safety reports (ICSRs) focusing cases COVID-19 indications...
Background: Chronic bronchitis (CB) is closely associated with the frequency and severity of chronic obstructive pulmonary disease (COPD) exacerbation. However, little known about impact CB on COPD exacerbations, severe non-severe, recovery from an Methods: We conducted a nation-wide multicenter cross-sectional survey in China between September 2007 December 2008. Eleven hospitals participated this study. Patients' demographic information, presence CB, overall numbers exacerbation leading to...
BackgroundNo comprehensive multicenter study of sensitization patterns among patients with allergic rhinitis (AR) to various common pollen allergens was available nationwide, and risks factors pollen-induced (PiAR) in mainland China unclear. This aimed fill this gap.MethodsA performed on 736 AR aged below 18 from four regions China. Patients completed a standardized questionnaire asking for the environmental risk severity, undertook skin prick tests (SPT) 14 allergens.FindingsAmong patients,...
Azithromycin and clarithromycin are commonly used to treat community-acquired pneumonia in adults aged ≥ 65, such as mycoplasma pneumonia. This study aims evaluate adverse events (AEs) associated with azithromycin this age group by analyzing the FDA Adverse Event Reporting System (FAERS), providing insights for clinical use management of AEs population.
Aim: Incretin therapies, including dipeptidyl peptidase-4 inhibitors (DPP-4is) and glucagon-like peptide-1 receptor agonists (GLP-1RAs), are crucial for type 2 diabetes treatment. Evidence on their association with gallbladder, biliary diseases liver injury remains inconsistent. This study evaluated the between incretin therapies hepatobiliary adverse events using FDA's Adverse Event Reporting System (FAERS) data. Methods: Case reports involving from January 2006 to December 2023 were...
COPD is often underdiagnosed in a primary care setting where the spirometry unavailable. This study was aimed to develop simple, economical and applicable model for screening those settings.First we established discriminant function based on Bayes' Rule by stepwise analysis, using data from 243 patients 112 non-COPD subjects our survey urban rural communities local settings Guangdong Province, China. We then used this discriminate additional 150 (50 100 ones) who had been recruited same...
The presence of increased oxidative stress and airway inflammation has been proven in subjects with chronic obstructive pulmonary disease (COPD). Several studies have demonstrated that drugs antioxidant anti-inflammatory properties such as N-acetylcysteine (NAC) can reduce the rate exacerbations patients COPD. However, beneficial effects NAC early-stage COPD are minimally discussed. We investigating whether high-dose therapeutic Chinese