A5005299656- Cardiac electrophysiology and arrhythmias
- Magnesium in Health and Disease
- Analytical Chemistry and Sensors
- Electrochemical Analysis and Applications
- Ion Channels and Receptors
- Neuroscience and Neural Engineering
- Advanced Battery Technologies Research
- Pulmonary Hypertension Research and Treatments
- Atomic and Subatomic Physics Research
- Optical Imaging and Spectroscopy Techniques
- Advanced Fluorescence Microscopy Techniques
- Advanced MRI Techniques and Applications
- Trace Elements in Health
- Advancements in Battery Materials
- Electrodeposition and Electroless Coatings
- Cardiac Arrhythmias and Treatments
- Advancements in Materials Engineering
- Photoreceptor and optogenetics research
- Plant Micronutrient Interactions and Effects
Lithuanian University of Health Sciences
2014-2021
TRPM7 channels participate in a variety of physiological/pathological processes. currents are modulated by protons but opposing effects external pH (pHo) (potentiation vs inhibition) have been reported. has less studied human cardiomyocytes than heart-derived non-cardiomyocyte cells. We used the whole-cell patch-clamp technique on isolated atrial to investigate impact an acidic pHo current. With voltage-dependent and other ion inhibited, were challenged with acidification either presence or...
Abstract Indocyanine green (ICG) fluorescent dye has been approved by the FDA for use in medical diagnostics. Recently, we demonstrated that ICG voltage-sensitive properties with a dual-component (fast and slow) response Langendorff-perfused rabbit heart. Here, extended our studies showing different spectral of both components analysis fractional change fluorescence to voltage changes. We used light from four LEDs obtain excitation; emission was measured using an EMCCD camera band-pass...
Despite the wide application of carvacrol (CAR) in medicines, dietary supplements, and foods, there is still insufficient electrophysiological data on mechanisms action CAR, particularly with regard to heart function. Therefore, this study, we attempted elucidate whether whose inhibitory effect both cardiac vascular TRPM7 L-type Ca 2+ currents has been demonstrated previously, could modify electrical activity. We used a combination optical mapping microelectrode techniques track potentials...
Elsholtzia ciliata essential oil (E. ciliata) has been developed in Lithuania and internationally patented as exerting antiarrhythmic properties. Here we demonstrate the pharmacological effects of this herbal preparation on cardiac electrical activity. We used surface ECG a combination microelectrode optical mapping techniques to track action potentials (APs) Langendorff-perfused rabbit heart model during atrial/endo-/epi-cardial pacing. Activation time, conduction velocity AP duration (APD)...
The expression of the channels-enzymes TRPM6 and TRPM7 in human heart remains poorly defined, is generally considered not to be expressed cardiomyocytes. We examined their at protein mRNA levels using right atrial samples resected from patients (n = 72) with or without ischemic disease (IHD) all chamber walls explanted hearts 9). proteins were detected immunofluorescence on isolated cardiomyocytes, ELISA tissue homogenates, immunostaining cardiac tissue, whereas mRNAs by RT-qPCR. Both...