Visceral allodynia and increased colonic permeability are considered to be crucial pathophysiology of irritable bowel syndrome (IBS). Corticotropin-releasing factor (CRF) immune-mediated mechanisms have been proposed contribute these changes in IBS, but the precise roles not determined. We explored issues rats vivo . The threshold visceromotor response, i.e., abdominal muscle contractions induced by balloon distention was electrophysiologically measured. Colonic estimated quantifying...

A glucagon-like peptide-1 analog, liraglutide, has been reported to block inflammatory somatic pain. We hypothesized that liraglutide attenuates lipopolysaccharide (LPS)-induced and repeated water avoidance stress (WAS)-induced visceral hypersensitivity tested the hypothesis in rats.The threshold of visceromotor response induced by colonic balloon distention was measured assess sensation. Colonic permeability determined vivo quantifying absorbed Evans blue spectrophotometrically, which...

Abstract Lipopolysaccharide (LPS) or repeated water avoidance stress (WAS) induces visceral allodynia and gut hyperpermeability via corticotropin-releasing factor (CRF) proinflammatory cytokines, which is a rat irritable bowel syndrome (IBS) model. As butyrate known to suppress the release of cytokine, we hypothesized that alleviates these colonic changes in IBS models. The pain was assessed by electrophysiologically measuring threshold abdominal muscle contractions response distention....

Abstract Background and Aim Repeated water avoidance stress (WAS) induces visceral hypersensitivity. Additionally, it is also known to activate corticotropin‐releasing factor (CRF), mast cells, pro‐inflammatory cytokines systems, but their precise roles on sensation have not been determined definitely. The aim of the study was explore this issue. Methods Abdominal muscle contractions induced by colonic balloon distention, that is, visceromotor response (VMR) detected electrophysiologically...

We analyzed the rate of polymyalgia rheumatica (PMR) and remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome, both characterized as inflammatory arthritis in elderly, an outpatient unit where primary care physicians are working Japan to better understand epidemiological characteristics diseases Japan. Consecutive outpatients who newly visited at Department General Medicine, Asahikawa Medical University Hospital, Japan, between April 2004 March 2010 were analyzed....

Functional abdominal pain syndrome (FAPS) has chronic unexplained and is similar to the psychiatric diagnosis of somatoform disorder. A patient with irritable bowel (IBS) also pain, rectal hypersensitivity observed in a majority patients. However, no reports have evaluated visceral sensory function FAPS precisely. We aimed test hypothesis that would show altered sensation compared healthy controls or IBS. The present study determined perceptual threshold, intensity using visual analogue...

Metformin has been shown to have anti-cytokine property. Lipopolysaccharide (LPS)-induced or repeated water avoidance stress (WAS)-induced visceral allodynia and increased gut permeability were pro-inflammatory cytokine-dependent responses, which considered be animal models of irritable bowel syndrome (IBS). We hypothesized that metformin improves symptoms in the patients with IBS by attenuating these changes tested hypothesis rats.The threshold visceromotor response induced colonic balloon...

Visceral hypersensitivity and impaired gut barrier are crucial contributors to the pathophysiology of irritable bowel syndrome (IBS), those mediated via corticotropin-releasing factor (CRF)−Toll like receptor 4–pro-inflammatory cytokine signaling. Phlorizin is an inhibitor sodium-linked glucose transporters (SGLTs), known have anti-cytokine properties. Thus, we hypothesized that phlorizin may improve these gastrointestinal changes in IBS, tested this hypothesis rat IBS models, i.e.,...

Grape seed extract (GSE) is rich in polyphenols composed mainly of proanthocyanidins, which are known to attenuate proinflammatory cytokine production. Repeated water avoidance stress (WAS) induces visceral allodynia and colonic hyperpermeability via toll-like receptor 4 (TLR4) pathways, a rat irritable bowel syndrome (IBS) model. Thus, we explored the effects GSE on repeated WAS (1 h for 3 days)-induced Sprague-Dawley rats. Paracellular permeability, as evaluated by transepithelial...

Lipopolysaccharide (LPS) or repeated water avoidance stress (WAS) induces visceral allodynia and colonic hyperpermeability via corticotropin-releasing factor (CRF) proinflammatory cytokines, which is considered to be a rat irritable bowel syndrome (IBS) model. As losartan known inhibit cytokine release, we hypothesized that it improves these changes.The threshold of visceromotor response (VMR), is, abdominal muscle contractions induced by balloon distention was electrophysiologically...

Hyponatremia is a common clinical problem that results from various causes. Hypothyroidism known to be one of the causes this disorder. We report case metastatic thyroid cancer presenting with severe hyponatremia in association hypothyroidism induced by pretreatment I(131) therapy, such as low-iodine diet and withdrawal hormone. Serum arginine vasopressin (AVP) was elevated urine osmolality higher than serum. Saline infusion hormone replacement normalized serum sodium AVP. Inappropriate...

Abstract Objective and Background: Stress‐induced visceral hypersensitivity may play an important role in the pathogenesis of irritable bowel syndrome (IBS) but not functional abdominal pain (FAPS). We examined rectal sensation those patients. Methodology: Experiment 1: Rectal thresholds (PT) maximum tolerance were assessed by barostat with ramp distention before after repetitive painful (RRD). 2, PT was measured basal state intravenous CRF (100 µg) or vehicle, together without RRD. 3: Three...

Visceral hypersensitivity and impaired gut barrier with minor inflammation are considered to play an important role in the pathophysiology of irritable bowel syndrome (IBS). Since pioglitazone is known have anti-inflammatory property, we hypothesized that beneficial for treating IBS. In this study, effect was tested rat IBS models such as lipopolysaccharide or repeated water avoidance stress-induced visceral allodynia increased colonic permeability. Pioglitazone blocked these changes,...

Little is known about the prevalence of primary and secondary headache in clinics Japan. The aim this study to characterize patients with an outpatient unit where care physicians are working Consecutive outpatients who newly visited Department General Medicine, Asahikawa Medical College Hospital, Asahikawa, Japan between April 2005 March 2009 were analyzed. Each parameter such as age, sex or diagnosis was investigated. Out 4693 patients, 418 our department because headache. Primary found 167...

We have recently demonstrated that N(6)-cyclopentyladenosine (CPA), an adenosine A1 receptor agonist, acts centrally to induce a visceral antinociception. Since serotonin (5-HT), cannabinoid (CB), dopamine or opioid signaling in the central nervous system is involved regulation of sensation, we made hypothesis may play role CPA-induced Visceral sensation was evaluated by colonic distension-induced abdominal withdrawal reflex (AWR) conscious rats. Subcutaneously administered CPA significantly...