A5060932660- Probiotics and Fermented Foods
- Gut microbiota and health
- Adipose Tissue and Metabolism
- Biochemical effects in animals
- Exercise and Physiological Responses
- Muscle metabolism and nutrition
- Nutrition and Health in Aging
- Muscle Physiology and Disorders
- Fatty Acid Research and Health
- Immune Response and Inflammation
- Lower Extremity Biomechanics and Pathologies
- Antioxidant Activity and Oxidative Stress
- Immune Cell Function and Interaction
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Nutritional Studies and Diet
- Diet and metabolism studies
- Antimicrobial Peptides and Activities
- Sesame and Sesamin Research
- Osteoarthritis Treatment and Mechanisms
- Body Composition Measurement Techniques
- Muscle activation and electromyography studies
- Viral gastroenteritis research and epidemiology
- Transgenic Plants and Applications
- Adipokines, Inflammation, and Metabolic Diseases
Suntory Foundation for Life Sciences
2010-2025
Suntory (Japan)
2007-2017
Tohoku University
2012
Okayama University
1998
<i>Background:</i> Many types of fermented food are consumed in Japan. Although some produced by plant-origin lactic-acid bacteria (LAB) fermentation, the physiological functions such remain unclear. We therefore isolated LAB plant origin from Kyoto pickles and determined immunological activity heat-killed preparations LAB. <i>Methods:</i> The <i>Lactobacillus pentosus</i> strain S-PT84 was selected among 16 as strongest interleukin (IL)-12-inducing...
Although quercetin has numerous biological benefits, including preventing muscle atrophy due to disuse, no reports have been published date about the preventive effects and molecular mechanisms underlying drug-induced atrophy. Highly soluble bioavailable glycosides (QGs) were used examine inhibition of dexamethasone (DEX)-induced in vivo. Male BALB/cCrSlc mice treated with or without QGs for 7 days ad libitum, followed by addition DEX their drinking water a further days. The weight...
Background/Objectives: As a result of aging societies, the increasing number older adults requiring nursing care has become serious issue and extension healthy life expectancy an urgent priority. Ergothioneine (EGT) is sulfur-containing amino acid found in foods such as mushrooms. Low EGT blood concentrations have been reported to be associated with risk onset progression various diseases. However, distribution their association dietary habits Japanese general population remains unclear....
Dietary habits are of considerable interest as a modifiable factor for the maintenance muscle health, especially sarcopenia. The present study aimed to investigate association between dietary intake and sarcopenia prevalence in community-dwelling Japanese subjects. This cross-sectional was conducted using data from fifth survey Research on Osteoarthritis/Osteoporosis against Disability (ROAD) study, 1345 participants (437 men 908 women) aged ≥60 years were included analysis. Sarcopenia...
Arachidonic acid (ARA), docosahexaenoic (DHA), and eicosapentaenoic (EPA), which are long-chain polyunsaturated fatty acids (LCPUFAs), as well lutein (L) zeaxanthin (Z), can potentially improve brain function. However, the effect of a combination these components (LCPUFAs + LZ) on memory function in healthy older individuals remains unclear. This study aimed to determine if LCPUFAs LZ-supplemented food could Exploratory confirmatory trials (Trials 1 2, respectively) were conducted Japanese...
Muscle satellite cells are committed myogenic progenitors capable of contributing to myogenesis maintain adult muscle mass and function. Several experiments have demonstrated that can differentiate into adipocytes in vitro, supporting the mesenchymal differentiation potential these cells. Moreover, may be a source ectopic adipocytes, explaining lipid accumulation often observed aged skeletal (sarcopenia) muscles patients` with diabetes. Quercetin, polyphenol, is one most abundant flavonoids...
Grape seed extract (GSE) is rich in polyphenols composed mainly of proanthocyanidins, which are known to attenuate proinflammatory cytokine production. Repeated water avoidance stress (WAS) induces visceral allodynia and colonic hyperpermeability via toll-like receptor 4 (TLR4) pathways, a rat irritable bowel syndrome (IBS) model. Thus, we explored the effects GSE on repeated WAS (1 h for 3 days)-induced Sprague-Dawley rats. Paracellular permeability, as evaluated by transepithelial...
Intestinal administration of various lactobacilli has been reported to affect autonomic neurotransmission, blood pressure, and body weight in rats. In this study, three molecules (peaks A, B, C) were isolated from Lactobacillus pentosus strain S-PT84 (S-PT 84) culture supernatants. Intraduodenal (ID) injection these increased or inhibited renal sympathetic nerve activity (RSNA) rats as follows: peak 134%; 40.1%; C, 408%. Furthermore, we identified C...
The effect of Lactobacillus pentosus strain S-PT84 (S-PT84) on postprandial hypertriacylglycerolemia was investigated in rats. dose-dependently inhibited the hydrolysis triacylglycerols by pancreatic lipase vitro. Intragastric administration significantly reduced lymphatic recovery (3)H-trioleoylglycerol up to 8 h. oral a fat emulsion, with or without S-PT84, resulted concentration plasma triacylglycerol 2 h and 3 after being lower group than (control group). These results suggest that...
l-Anserine, an imidazole peptide, has a variety of physiological activities, but its effects on skeletal muscle differentiation and contractile force remain unknown. Thus, in this study, we investigated the effect l-anserine human cells. In two-dimensional culture, 1 μM significantly increased myotube diameters (26.5 ± 1.71, 27.7 1.08, 28.8 0.85 μm with 0, 0.1, l-anserine, respectively) expression levels genes involved sarcomere structure. three-dimensional engineered tissues cultured...
Lactobacillus pentosus (L. pentosus) strain S-PT84, isolated from Kyoto pickles, enhances splenic natural killer (NK) cell activity, and has high T-helper1 (Th1) cytokine type 1-IFN (IFN-α) inducing activity. In the present study, we investigated influence of S-PT84 ingestion on mucosal immunity healthy Salmonella Typhimurium (S. Typhimurium)-infected mice. S. infection model, numbers in feces spleen were significantly decreased, body weight loss deterioration general health score...
Lactobacillus pentosus S-PT84, which was isolated from Kyoto pickles, enhances splenic natural killer (NK) cell activity, increases IgA production Peyer's patch cells and has high T-helper 1 (Th1) cytokine type 1-interferon-inducing activity. However, all of these effects were obtained by using heat-killed S-PT84. In the present study, we investigated immunomodulatory effect live S-PT84 in BALB/c mice. Unexpectedly, indicated weak activity on Th1 (interleukin-12 or interferon-γ) splenocytes...
We previously showed a prophylactic effect of Lactobacillus pentosus strain S-PT84 against oral candidiasis in mice. In the present study, we evaluated protective Candida infection gastrointestinal tract. As first step, used an vitro assay to compare inhibitory effects several lactobacilli (S-PT84 and type JCM1558T, gasseri JCM1131T casei JCM1134T) on mycelial growth albicans. directly adhered cells strongest growth-inhibitory activity among tested strains. second experiment, vivo evaluate...
Aging of skeletal muscle is characterized not only by a decrease quantity but also changes in quality, such as an increase stiffness. The present study aimed to investigate the effects supplementation with quercetin glycosides (QGs), well-known polyphenolic flavonoids, combined resistance exercise on and
Multifactorial lifestyle approaches could be more effective than a single factor for maintaining cognitive function. This study investigated the association of combining cognitively stimulating leisure activities (CSLAs), including puzzles, quizzes, and training games, with intake long-chain polyunsaturated fatty acids (LCPUFAs), docosahexaenoic acid (DHA), eicosapentaenoic (EPA), arachidonic (ARA), on function in older Japanese individuals without dementia. Participants were...
Skeletal muscle comprises slow and fast myofibers, with myofibers excelling in aerobic metabolism endurance. Quercetin, a polyphenol, is reported to induce rodent skeletal both vitro vivo. However, its effect on human myofiber types remains unexplored. In this study, we evaluated quercetin's impact induction using satellite cells. two-dimensional culture, quercetin enhanced gene expression, contributing differentiation, significantly expanded the area of slow-type myosin heavy chain positive...
Background/Objectives: Circadian clocks are endogenous systems that regulate numerous biological, physiological, and behavioral events in living organisms. Aging attenuates the precision robustness of circadian clocks, leading to prolonged dampened gene oscillation rhythms amplitudes. This study investigated effects food-derived polyphenols such as ellagic acid its metabolites (urolithin A, B, C) on aging clock at cellular level using senescent human fibroblast cells, TIG-3 cells. Methods:...