A5090731593- Fatty Acid Research and Health
- Diet and metabolism studies
- Eicosanoids and Hypertension Pharmacology
- Nutritional Studies and Diet
- Peroxisome Proliferator-Activated Receptors
- Lipid metabolism and biosynthesis
- Alzheimer's disease research and treatments
- Antioxidant Activity and Oxidative Stress
- Adipose Tissue and Metabolism
- Hormonal and reproductive studies
- Birth, Development, and Health
- Metabolomics and Mass Spectrometry Studies
- Anesthesia and Pain Management
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Meningioma and schwannoma management
- Biochemical effects in animals
- Cancer, Lipids, and Metabolism
- Prostate Cancer Treatment and Research
- Sperm and Testicular Function
- Alcoholism and Thiamine Deficiency
- Neurogenesis and neuroplasticity mechanisms
- Growth Hormone and Insulin-like Growth Factors
- Antiplatelet Therapy and Cardiovascular Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
Suntory Foundation for Life Sciences
2009-2024
National Center for Geriatrics and Gerontology
2022-2024
Suntory (Japan)
2011-2015
Omega-6 (n-6) and omega-3 (n-3) polyunsaturated fatty acids (PUFAs) are essential nutrients. Although several studies have suggested that a balanced dietary n-6:n-3 ratio is for brain development, the underlying cellular molecular mechanism poorly understood. Here, we found feeding pregnant mice an n-6 excess/n-3 deficient diet, which reflects modern human diets, impairsed neocortical neurogenesis in offspring. This impaired neurodevelopment occurs through precocious fate transition of...
The importance of arachidonic acid (ARA) among the elderly has recently gained increased attention. effects ARA supplementation in are not fully understood, although is considered to be associated with various diseases. We investigate whether Japanese subjects affects clinical parameters involved cardiovascular, inflammatory, and allergic also examine levels metabolites such as prostanoids during intervention.We conducted a randomized, double-blind placebo-controlled parallel group...
It is believed that the amyloid β-protein (Aβ) plays a causative role in development of Alzheimer's disease (AD). The amyloid-β protein precursor (AβPP), substrate Aβ, and β-secretase γ-secretase complex proteins, which process AβPP to generate are all membrane proteins. Thus, it reasonable assume alterations brain lipid metabolism modulate and/or Aβ metabolism. However, cellular polyunsaturated fatty acids processing has not been completely understood yet. We report here 4 months treatment...
Several studies have reported that the supplementation of long-chain polyunsaturated fatty acids (LCPUFA), such as docosahexaenoic acid (DHA), eicosapentaenoic (EPA), and arachidonic (ARA) improve cognitive function in elderly. However, doses used these were higher than general dietary LCPUFA intake levels. This randomized, double-blind, placebo-controlled trial evaluated effects low corresponding to on non-demented elderly Japanese participants. men aged 55-64 years enrolled randomly...
Arachidonic acid (ARA), docosahexaenoic (DHA), and eicosapentaenoic (EPA), which are long-chain polyunsaturated fatty acids (LCPUFAs), as well lutein (L) zeaxanthin (Z), can potentially improve brain function. However, the effect of a combination these components (LCPUFAs + LZ) on memory function in healthy older individuals remains unclear. This study aimed to determine if LCPUFAs LZ-supplemented food could Exploratory confirmatory trials (Trials 1 2, respectively) were conducted Japanese...
Omega-6 (n-6) and omega-3 (n-3) polyunsaturated fatty acids (PUFAs) are essential nutrients for normal brain development. The principal dietary n-6 n-3 PUFAs linoleic acid (LA) α-linolenic (ALA), respectively, We have previously shown that maternal imbalance between these PUFAs, i.e., rich in LA poor ALA, affected development increased anxiety-related behavior the mouse offspring. Here we further addressed sex difference offspring exposed to LA:ALA imbalance. fed pregnant mice a excess/ALA...
Arachidonic acid (ARA) is an n-6 PUFA and thought to have important role in various physiological psychological functions. Recently, supplementation with ARA-enriched TAG was shown improve age-related decreases cognitive function healthy elderly men. To investigate the influence of baseline serum ARA status on its improvement, we analyzed stratified by level. The analysis also conducted for effects improvement. Cognitive evaluated measuring event-related potentials (ERPs), including P300...
Abstract Multifactorial lifestyle intervention is known to be more effective for ameliorating cognitive decline than single factor intervention; however, the effects of combining exercise with long-chain polyunsaturated fatty acids (LCPUFA) on elderlies' function remain unclear. We conducted a randomised, single-masked placebo-controlled trial in non-demented elderly Japanese individuals. Participants were randomly allocated LCPUFA, placebo, or no placebo (control) groups. groups performed...
Multifactorial lifestyle approaches could be more effective than a single factor for maintaining cognitive function. This study investigated the association of combining cognitively stimulating leisure activities (CSLAs), including puzzles, quizzes, and training games, with intake long-chain polyunsaturated fatty acids (LCPUFAs), docosahexaenoic acid (DHA), eicosapentaenoic (EPA), arachidonic (ARA), on function in older Japanese individuals without dementia. Participants were...
Although several studies have reported the effects of long-chain polyunsaturated fatty acid (LCPUFA) supplementation on mood in healthy adults, LCPUFA elderly individuals remain unclear. Thus, we hypothesized that improves elderly. To address this hypothesis, 115 Japanese men aged 55-64 years were assigned and randomly allocated to or placebo group. Participants received 4 weeks with LCPUFA-containing oil (docosahexaenoic (DHA) 300 mg/day, eicosapentaenoic (EPA) 100 arachidonic (ARA) 120...
Social connections are essential for human health. While curiosity and empathy crucial psychological factors a fulfilling life connected with others, it is unclear if acquired environmental influence them. In this cross-sectional observational study, 1,311 men women aged 20-79 years living in Japan were observed to explore how lifestyle such as diet, sleep, leisure activities (such exercise hobbies) impact empathy. A hierarchical multiple regression analysis revealed that diet impacted...