A5065257294- Angiogenesis and VEGF in Cancer
- Nitric Oxide and Endothelin Effects
- Hippo pathway signaling and YAP/TAZ
- Cancer, Hypoxia, and Metabolism
- Cell Adhesion Molecules Research
- Eicosanoids and Hypertension Pharmacology
- Hormonal Regulation and Hypertension
- Connective tissue disorders research
- Computational Drug Discovery Methods
- Kruppel-like factors research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Atherosclerosis and Cardiovascular Diseases
- Cardiac Valve Diseases and Treatments
- RNA and protein synthesis mechanisms
- Protease and Inhibitor Mechanisms
- Barrier Structure and Function Studies
- Inflammatory mediators and NSAID effects
- Advanced biosensing and bioanalysis techniques
- Cardiomyopathy and Myosin Studies
- Caveolin-1 and cellular processes
- Ubiquitin and proteasome pathways
Uppsala University
2021-2023
Science for Life Laboratory
2021-2022
Goethe University Frankfurt
2014-2019
German Centre for Cardiovascular Research
2019
The University of Texas Southwestern Medical Center
2014
Max Delbrück Center
2014
Vascular endothelial (VE)-cadherin in adherens junctions is an essential component of the vascular barrier, critical for tissue homeostasis and implicated diseases such as cancer retinopathies. Inhibitors Src cytoplasmic tyrosine kinase have been applied to suppress VE-cadherin phosphorylation prevent excessive leakage, edema high interstitial pressure. Here we show that Src-related Yes kinase, rather than Src, localized at cell (EC) where it becomes activated a flow-dependent manner....
Endothelial phospholipase Cγ (PLCγ) is essential for vascular development; however, its role in healthy, mature, or pathological vessels unexplored. Here, we show that PLCγ was prominently expressed of several human cancer forms, notably renal cell carcinoma (RCC). High expression clear RCC correlated with angiogenic activity and poor prognosis, while low immune activation. induced downstream endothelial growth factor receptor 2 (VEGFR2) phosphosite Y1173 (pY1173). Heterozygous...
Cytochrome P450–derived epoxides of arachidonic acid [i.e., the epoxyeicosatrienoic acids (EETs)] are important lipid signaling molecules involved in regulation vascular tone and angiogenesis. Because many actions 11,12-<i>cis</i>-epoxyeicosatrienoic (EET) dependent on activation protein kinase A (PKA), existence a cell-surface G<sub>s</sub>-coupled receptor has been postulated. To assess whether responses endothelial cells to 11,12-EET enantiomer specific linked potential G protein–coupled...
Abstract Aim Protein kinase (PK) A anchoring protein (AKAP) 12 is a scaffolding that anchors PKA to compartmentalize cyclic AMP signalling. This study assessed the consequences of downregulation or deletion AKAP12 on endothelial cell migration and angiogenesis. Methods The siRNA‐mediated were studied in primary cultures human cells as well retinas from wild‐type versus −/− mice. Molecular interactions investigated using combination immunoprecipitation mass spectrometry. Results was expressed...
PALMD (palmdelphin) belongs to the family of paralemmin proteins implicated in cytoskeletal regulation. Single nucleotide polymorphisms locus that result reduced expression are strong risk factors for development calcific aortic valve stenosis and predict severity disease.Immunodetection public database screening showed dominant endothelial cells (ECs) brain cardiovascular tissues including valves. Mass spectrometry, coimmunoprecipitation, immunofluorescent staining allowed identification...
Cytochrome P450 (CYP)‐derived epoxides of arachidonic acid, i.e., the epoxyeicosatrienoic acids (EETs), are important lipid signaling molecules. Since many actions 11,12‐EET dependent on activation protein kinase A (PKA), existence a cell surface Gs‐coupled receptor has been postulated. To assess whether responses endothelial cells to enantiomer specific and linked potential G protein‐coupled receptor, we assessed 11,12‐EET‐induced, PKA‐dependent translocation transient (TRP) C6 channels as...
Abstract Vascular Endothelial (VE)-cadherin in endothelial adherens junctions is an essential component of the vascular barrier, critical for tissue homeostasis and implicated progression diseases such as cancer eye diseases. Inhibitors SRC cytoplasmic tyrosine kinase have been applied to suppress phosphorylation VE-cadherin thereby prevent excessive leakage, edema high interstitial pressure. We show that SRC-related YES rather than SRC, localized at cell (EC) junctions. EC-specific deletion...