A5058333118- Dialysis and Renal Disease Management
- Muscle and Compartmental Disorders
- Central Venous Catheters and Hemodialysis
- Cardiovascular Function and Risk Factors
- Cardiovascular and exercise physiology
- Blood Pressure and Hypertension Studies
- Exercise and Physiological Responses
- Chronic Kidney Disease and Diabetes
- Cardiac Health and Mental Health
- Cardiac Imaging and Diagnostics
- Pharmacological Effects and Toxicity Studies
- Advanced MRI Techniques and Applications
- Physical Activity and Health
- Organ Donation and Transplantation
- Organ Transplantation Techniques and Outcomes
- Apelin-related biomedical research
- Heart Failure Treatment and Management
- Climate Change and Health Impacts
- Health Systems, Economic Evaluations, Quality of Life
- Heart Rate Variability and Autonomic Control
- Autoimmune and Inflammatory Disorders Research
- Body Composition Measurement Techniques
- Hemodynamic Monitoring and Therapy
- Grief, Bereavement, and Mental Health
- Peripheral Artery Disease Management
University of Leicester
2015-2024
Leicester General Hospital
2015-2021
University Hospitals of Leicester NHS Trust
2016-2021
NIHR Leicester Biomedical Research Centre
2021
Native T1 mapping is a cardiovascular magnetic resonance (CMR) technique that associates with markers of fibrosis and strain in hemodialysis patients. The reproducibility patients, prone to changes fluid status, unknown. Accurate quantification myocardial this population has prognostic potential.
There is emerging evidence that exercise training could positively impact several of the cardiovascular risk factors associated with sudden cardiac death amongst patients on haemodialysis. The primary aim this study to evaluate effect an intradialytic programme left ventricular mass. Prospective, randomised cluster open-label blinded endpoint clinical trial in 130 end stage renal disease Patients will be 1:1 either 1) minimum 30 min continuous cycling thrice weekly during dialysis or 2)...
Cardiovascular disease is the most common cause of mortality in haemodialysis (HD) patients and highly predicted by markers chronic inflammation. Regular exercise may have beneficial anti-inflammatory effects, but this unclear HD patients. This study assessed effect regular intradialytic on soluble inflammatory factors leucocyte phenotypes.Twenty-two from a centre where cycling was offered thrice weekly 16 receiving usual care volunteered. Exercising aimed to cycle for 30 min at rating...
No formal cost-effectiveness analysis has been performed for programs of cycling exercise during dialysis (intradialytic [IDC]). The objective this is to determine the effect a 6-month program IDC on health care costs.This retrospective adult participants with end-stage kidney disease undertaking in-center maintenance hemodialysis enrolled in CYCLE-HD trial. Data hospital utilization, primary consultations, and prescribed medications were extracted from medical records 6 months before,...
Research evidence outlines the benefits of intradialytic exercise (IDE), yet implementation into practice has been slow, ostensibly due to a lack patient and staff engagement. The aim this quality improvement project was improve outcomes via introduction an IDE programme, evaluate uptake sustainability enhance engagement routine haemodialysis (HD) with delivery programme. We developed refined including interventions designed increase that were based on Theoretical Domains Framework (TDF),...
Extended periods of haemodialysis (HD) can improve patient outcomes. In-centre nocturnal (INHD) should be explored as a method offering extended HD to patients unsuitable for or unable perform home therapy.Ten self-selecting, prevalent started an INHD programme assess feasibility and satisfaction. Quality-of-life (QOL) measures were evaluated at enrolment after 4 months using the EQ-5D, Hospital Anxiety Depression Scale (HADS) SF-12 questionnaires. Demographic, biochemical haematological...
Evidence suggests extended-hours haemodialysis (HD) may improve cardiovascular, medical and quality-of-life outcomes. In-centre nocturnal (INHD) is an established but underutilized method of providing treatment. This 6-month, non-randomized controlled trial (ISRCTN16672784) recruited 13 INHD patients 12 control on conventional HD. The effects treatment left ventricular (LV) structure, function myocardial fibrosis were assessed using cardiac magnetic resonance imaging native T1 mapping....
Abstract Background Intradialytic cycling (IDC) may provide cardiovascular benefits to individuals receiving haemodialysis, but the exact mechanism behind these improvements remains unclear. The primary aim of this study was investigate effect a 6-month programme IDC on circulating endotoxin (secondary analysis from CYCLE-HD trial). Secondary aims were changes in cytokines [interleukin-6 (IL-6), IL-10, tumour necrosis factor-α, C-reactive protein (CRP) and IL-6:IL-10 ratio] their...
Abstract Purpose Patients receiving haemodialysis (HD) display elevated circulating microparticle (MP) concentration, tissue factor (TF) expression and markers of systemic inflammation, though regular intradialytic cycling (IDC) may have a therapeutic effect. This study investigated the impact regular, moderate-intensity IDC on MPs inflammatory in unit-based HD patients. Methods were cluster-randomised to intervention ( n = 20, age: 51.4 ± 18.1 years, body mass: 77.6 18.3 kg, mean SD) or...
Abstract Introduction End‐stage kidney disease causes significant morbidity, mortality, and reduced quality of life. Despite improvements in conventional hemodialysis, these problems persist. In‐center nocturnal hemodialysis (INHD) has been shown to be beneficial observational studies. This report outlines a 4‐year renal network experience INHD from the patient frontline staff perspective. Methods Staff patients' experiences were evaluated through two work streams. Work stream one: 12...
In-centre nocturnal haemodialysis (INHD) is an underutilised dialysis regimen that can potentially provide patients with better clinical outcomes due to extended treatment times. We have established INHD programme within our network, fulfilling a previously unmet patient need. This feasibility study aims gather sufficient data on numerous outcome measures inform the design of multicentre randomised controlled trial will establish potential benefits and increase availability this service...
The haemodialysis (HD) population is sedentary, with substantial cardiovascular disease risk. In the general population, small increases in daily step count associate significant reductions mortality. This study explores relationship between and surrogate markers of disease, including left ventricular ejection fraction (LVEF) native T1 (a marker diffuse myocardial fibrosis), within HD population.
between TSAT and cardiac function in maintenance hemodialysis patients has yet to be investigated.METHODS: We conducted a cross-sectional study included 100 outpatients receiving (78 men 22 women).The were divided into two groups according the mean levels during last 1 year (low group; <20% (n=51), high 20% (n=49)).The was assessed by echocardiography.RESULTS: Age, Kt/V, nPCR, Alb, blood pressure comparable groups.In low group, left atrial dimension (LAD) (41.7 vs. 38.1 mm, p < 0.05)...