- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Crystal structures of chemical compounds
- Cancer therapeutics and mechanisms
- Synthesis and Biological Evaluation
- Crystallography and molecular interactions
- Synthesis and biological activity
- Bioactive Compounds and Antitumor Agents
- Phenothiazines and Benzothiazines Synthesis and Activities
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Chemical Thermodynamics and Molecular Structure
- Fluorine in Organic Chemistry
- Thermal and Kinetic Analysis
- Chemical Synthesis and Analysis
- Nonlinear Optical Materials Research
- Synthesis and Reactions of Organic Compounds
- Molecular Sensors and Ion Detection
- Cancer Treatment and Pharmacology
- Photochemistry and Electron Transfer Studies
- Free Radicals and Antioxidants
- Osteoarthritis Treatment and Mechanisms
- Hydrogels: synthesis, properties, applications
- Radical Photochemical Reactions
- Advanced Chemical Physics Studies
- Proteoglycans and glycosaminoglycans research
University of Gdańsk
2013-2024
Faculty (United Kingdom)
2015-2016
V. N. Karazin Kharkiv National University
2010
Pacific Northwest National Laboratory
2003-2008
Battelle
2003-2004
1,3-Diphenylisobenzofuran (DPBF) has been developed as a selective probe for the detection and quantitative determination of hydrogen peroxide in samples containing different reactive nitrogen oxygen species (RNOS). DPBF is fluorescent which, almost 20 years, was believed to react highly specific manner toward some (ROS) such singlet hydroxy, alkyloxy or alkylperoxy radicals. Under action these individuals rapidly transformed 1,2-dibenzoylbenzene (DBB). In order check if can act unique...
10-Methyl-9-(phenoxycarbonyl)acridinium trifluoromethanesulfonates bearing alkyl substituents at the benzene ring were synthesized, purified, and identified. In reaction with OOH(-) in basic aqueous media, cations of compounds investigated converted to electronically excited 10-methyl-9-acridinone, whose relaxation was accompanied by chemiluminescence (CL). The kinetic constants CL decay, relative efficiencies light emission, quantum yields, resistance toward alkaline hydrolysis determined...
A flavonol-based ESIPT fluorescence probe for evaluation of β-glucosidase activity was synthesized and tested sensitivity to enzymatic cleavage at different conditions.
A series of 10-methyl-9-(phenoxycarbonyl)acridinium trifluoromethanesulfonates (XAEs), bearing substituents various characteristics in the lateral benzene ring (2-halogen, 2,6-dihalogen, 2-trifluoromethyl, 2-nitro, 2-methoxy, 3-halogen and 4-halogen) were synthesized with high yields, identified subjected to a physicochemical theoretical investigation. The main task work was assess mechanism optimal conditions light emission liquid systems based on above salts order evaluate their potential...
<b><i>Aim:</i></b> (1) To describe the whole blood content of thiamine diphosphate (TDP), a biologically active form vitamin B1 in end-stage kidney disease patients treated with hemodialysis (HD); (2) to establish impact single HD procedure on TDP concentrations; and (3) potential explanatory variables influencing dialysis related losses, including prescription, dietary intake supplementation. <b><i>Methods:</i></b> Single-center,...
Abstract We have evaluated a biomaterial to serve as scaffold for the propagation and amplification of chondrocytes that promotes original cellular phenotype these cells. The goal present study was investigate use thermally reversible polymer gels poly(NiPAAm‐ co ‐AAc), biocompatible supporting chondrocytic at temperatures above its lower critical solution temperature whereas liquefying below 34.5°C. Hence, polymer, in gelled form, has ability hold cells situ , forming matrix similar natural...
The chemiluminogenic (CL) properties of aryl esters 9-carboxy-10-methylacridinium acid and 9-carboxy-2-methoxy-10-methylacridinium (AE), variously substituted in the benzene ring (2-H, 2-CH(3), 2-Cl) were investigated aliphatic alcohols, acetonitrile, dimethyl sulfoxide presence hydrogen peroxide different bases-potassium hydroxide, tetra-n-butylammonium 1,8-diazabicyclo[5.4.0]undec-7-ene. dependence their CL (decay rate constants (k(CL)) relative efficiencies (RE)) on solvent parameters,...
Abstract Acridinium salts, due to their chemiluminogenic properties, have found several applications in biomedical analysis as labels and indicators, where the assessment of emission intensity is used for end‐point detection. This work presents use chemiluminescent indicators form selected acridinium esters order determine antioxidant properties exemplary formulations, namely quercetin, vitamin C dietary supplement, Apiextract . The principle measurements based on a change kinetics decay...
Biologically active compounds containing sulfhydryl groups (RSHs: N-acetyl-l-cysteine, d-penicillamine, glutathione and acetylthiocholine chloride) were used to develop a luminometric method for their quantification. The title substrate capable of chemiluminescence (CL) was isolated in highly pure state as chloride salt (99.9% using RP-HPLC) identified mass spectrometry (ESI Q-TOF) 1 H NMR spectroscopy. cation included the salt, 9-CMA+ , underwent oxidation an alkaline environment RSHs by...
Abstract The acridanone derivative 5‐dimethylaminopropylamino‐8‐hydroxytriazoloacridinone (C‐1305) has been described as a potent inhibitor of cancer cell growth. Its mechanism action in vitro conditions was attributed, among others, to its ability bind and stabilize the microtubule network subsequently exhibit tumour‐suppressive effects synergy with paclitaxel (PTX). Therefore, objective present study analyse combined treatment C‐1305 PTX vivo. In addition, considering results previous...
Abstract We previously evaluated a thermoreversible polymer gel composed of N ‐isopropylacrylamide and acrylic acid as cell culture substrate cell‐delivery vehicle. The copolymer promoted phenotype expression amplification chondrocytes. In this study, we determined whether addition fibroblast growth factor 9 (FGF‐9), which is mitogenic for chondrocytes, would further enhance proliferation in the polymer. tested hypothesis that containing FGF‐9 promote increased chondrocyte expression....
Abstract The 1 H and 13 C NMR spectra of 9‐(methoxyamino)acridine ( ) 9‐hydrazinoacridine 2 show that these compounds exist principally in the imino tautomeric form CDCl 3 , acetone‐ d 6 CD CN, DMSO‐ Py‐ 5 all solvents with different polarities abilities to participate specific interactions. other two investigated— N ‐(2‐chloroethyl)acridin‐9‐amine ‐(5‐methylpyridin‐2‐yl)acridin‐9‐amine 4 )—indicate they coexist amino forms. tautomer compound predominates CN . On hand, forms probably whereas...
Rational drug design and in vitro pharmacology profiling constitute the gold standard development pipelines. Problems arise, however, because this process is often difficult due to limited information regarding complete identification of a molecule's biological activities. The increasing affordability genome-wide next-generation technologies now provides an excellent opportunity understand compound's diverse effects on gene regulation. Here, we used unbiased approach lung colon cancer cell...
The title compounds, C21H14F2NO2+.CF3SO3-, (I), and C20H11F2NO2, (II), form monoclinic triclinic crystals, respectively. Adjacent cations of (I) are oriented in a ;head-to-tail' manner linked to one another via networks C-H...O, C-F...pi, S-O...pi multidirectional pi-pi interactions. molecules (II) also arranged C-H...O mean planes the acridine moieties lie parallel lattices both compounds. benzene rings parallel. However, difluorophenyl mutually at an angle 17.3 (2) degrees 5.8 (II). This...
Abstract Ionic copolymers of N ‐isopropylacrylamide (NIPA) exhibiting sol–gel transitions in aqueous solutions were investigated. The studies aimed at understanding the structure–property relationship design injectable, situ forming gels for potential biomedical applications delivery therapeutics and tissue engineering. Aqueous NIPA ionic found to flow freely ambient temperatures formed soft with controlled syneresis above 32 °C, lower critical solution temperature NIPA....