A5000580616- Vitamin D Research Studies
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Metal complexes synthesis and properties
- Estrogen and related hormone effects
- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Cancer Cells and Metastasis
- Synthesis and Biological Evaluation
- Crystallography and molecular interactions
- Alzheimer's disease research and treatments
- Hops Chemistry and Applications
- Vitamin C and Antioxidants Research
- Cancer, Hypoxia, and Metabolism
- Cancer therapeutics and mechanisms
- Thermal and Kinetic Analysis
- Chromatography in Natural Products
- Lanthanide and Transition Metal Complexes
- Cell Adhesion Molecules Research
- Advanced Breast Cancer Therapies
- PI3K/AKT/mTOR signaling in cancer
- GDF15 and Related Biomarkers
- Click Chemistry and Applications
- Crystal structures of chemical compounds
- Organometallic Compounds Synthesis and Characterization
Polish Academy of Sciences
2016-2025
Ludwik Hirszfeld Institute of Immunology and Experimental Therapy
2016-2025
University of Wrocław
2023
Polish Academy of Learning
2017-2020
Ripamonti
2018
Wrocław University of Science and Technology
2008
Instytut Farmaceutyczny
2003
Xanthohumol (XN) and four minor hops prenylflavonoids: α,β-dihydroxanthohumol (2HXN), isoxanthohumol (IXN), 8-prenylnaringenin (8PN), 6-prenylnaringenin (6PN), were tested for antiproliferative activity towards human cancer normal cell lines. Nonprenylated naringenin (NG) was used as a model compound. Xanthohumol, the most active compounds. exhibited higher than cisplatin (CP) against five lines: ovarian resistant to A2780cis, breast MDA-MB-231 T-47D, prostate PC-3, colon HT-29....
The antiproliferative activity of xanthohumol (1), a major prenylated chalcone naturally occurring in hops, and its aurone type derivative (Z)-6,4′-dihydroxy-4-methoxy-7-prenylaurone (2) were investigated. Both flavonoids, as well cisplatin reference anticancer drug, tested vivo against ten human cancer cell lines (breast (MCF-7, SK-BR-3, T47D), colon (HT-29, LoVo, LoVo/Dx), prostate (PC-3, Du145), lung (A549) leukemia (MV-4-11) two normal (human microvascular endothelial (HLMEC)) murine...
At present, effective anticancer therapy remains one of the most challenging tasks facing scientific community. A major limitation to conventional low-molecular weight chemotherapeutics is their unfavourable uptake by healthy tissue, fast metabolism and lack tumour cell selectivity. One way solve this problem application hybrid nanoparticles containing widely known therapeutic substances. This study was performed with aim investigating potential use hydroxyethyl starch (HES) as a...
In the present study, we evaluated antitumor effect of two synthetic analogs vitamin D, namely PRI-2191 [(24R)-1,24-dihydroxyvitamin D3] and PRI-2205 (5,6-trans calcipotriol), in combined human colon HT-29 cancer treatment with 5-fluorouracil (5-FU). Mice bearing tumors transplanted subcutaneously or orthotopically were injected D 5-FU various schedules. A statistically significant inhibition subcutaneous orthotopic tumor growth was observed as a result therapy. cells from vitro culture,...
Low vitamin D status is considered as a risk factor for breast cancer and has prognostic significance. Furthermore, deficiency increases after adjuvant therapy, which alters bone metabolism increasing the of osteoporosis. It now postulated that supplementation in treatment delays recurrence thereby extending survival. We evaluated impact calcitriol its low-calcemic analogs, PRI‑2191 PRI‑2205, on tumor growth, angiogenesis, metastasis 4T1 mouse mammary gland cancer. Gene expression analysis...
Numerous in vitro and vivo studies have demonstrated that calcitriol [1,25(OH)2D3] different vitamin D analogs possess antineoplastic activity, regulating proliferation, differentiation apoptosis, as well angiogenesis. Vitamin compounds been shown to exert synergistic effects when used combination with agents anticancer therapies cancer models. The aim of this study was evaluate the mechanisms cooperation [1,24(OH)2D3 (PRI‑2191) 1,25(OH)2D3] tyrosine kinase inhibitors (imatinib sunitinib)...
In our previous study, calcitriol and its analogs PRI-2191 PRI-2205 stimulated 4T1 mouse mammary gland cancer metastasis. Therefore, we aimed to analyze the inflammatory response in 4T1-bearing mice treated with these compounds. Gene expression analysis of splenocytes regional lymph nodes demonstrated prevalence T helper lymphocytes (Th2) an increased activity regulatory (Treg) We also observed number mature granulocytes B a decreased TCD4+, TCD4+CD25+, TCD8+, as well natural killer (NK)...
Long-acting insulins are part of the WHO’s List Essential Medicines, which highlights their importance in treatment diabetes. Often mode action relies on albumin binding propensity they owe to chemical conjugations with fatty acids. In this work, we propose an alternative development strategy for albumin-binding through metallacarborane conjugation. study, insulin was modified newly synthesised aldehyde-bearing metallacarboranes reductive aminations yield insulin-metallacarborane conjugates...
Diastereomeric and geometric analogs of calcipotriol, PRI-2202 PRI-2205, were synthesized as advanced intermediates from vitamin D C-22 benzothiazoyl sulfones side-chain aldehydes using our convergent strategy. Calcitriol, calcipotriol (PRI-2201) tacalcitol (PRI-2191) used the reference compounds. Among a series tested diastereomeric analog showed strongest antiproliferative activity on human breast cancer cell line MCF-7, whereas PRI-2205 was weakest. Both less potent in against HL-60 cells...
In previous papers, we presented data on studies the anticancer activity of vitamin D₃ analogs, named PRI-2191 and PRI-2205, in different cancer models. this study, showed improved antiproliferative a combination imatinib mesylate (Gleevec, GV) cytostatic agents vitro studies, when used with third compound, namely PRI-2191, an A549 human lung model. Furthermore, analyzed influence both as well PRI-2205 GV mice bearing tumors. The route analog administration significant impact outcome...
Calcitriol and its analogues are considered drugs supporting the anticancer treatment of breast cancer preventing osteoporosis that results from development or chemotherapy hormone therapy. Following orthotopic implantation 4T1 mammary carcinoma cells into aged ovariectomized (OVX) mice, we evaluated effects calcitriol two analogues, PRI-2191 PRI-2205, on metastatic spread bone homeostasis. temporarily inhibited formation metastases in lungs. Unexpectedly, only mice treated with showed a...
The use of hybrid molecules has become one the most significant approaches in new cytotoxic drug design. This study describes synthesis and characterization conjugates consisting two well-known characterized chemotherapeutic agents: methotrexate (MTX) epirubicin (EPR). synthesized combine anticancer strategies: combinatory therapy targeted therapy. These drugs were chosen because they have different mechanisms action, which can increase effect obtained conjugates. MTX, is a folic acid...
1,25-Dihydroxycholecalciferol, the hormonally active vitamin D3 metabolite, is known to exhibit therapeutic effects against breast cancer, mainly by lowering expression of estrogen receptors and aromatase activity. Previously, safety D metabolite (24R)-1,24-dihydroxycholecalciferol (PRI-2191) 1,25(OH)2D3 analog PRI-2205 was tested, in vitro activity these analogs different cancer cell lines studied. We determined effect two compounds on anastrozole (An) based antiproliferative activity,...