A5054150364- Coenzyme Q10 studies and effects
- Plant biochemistry and biosynthesis
- Mosquito-borne diseases and control
- Photosynthetic Processes and Mechanisms
- Malaria Research and Control
- Bioactive Compounds and Antitumor Agents
Universidade de São Paulo
2019-2023
Atovaquone (AV) acts on the malaria parasite by competing with ubiquinol (UQH 2 ) for its union to mitochondrial bc 1 complex, preventing ubiquinone-8 and ubiquinone-9 (UQ-8 UQ-9) redox recycling, which is a necessary step in pyrimidine biosynthesis. This study focused UQ biosynthesis Plasmodium falciparum adopted proof-of-concept research better elucidate mechanism of action AV improve efficacy.
Abstract Ubiquinone (UQ) is a fundamental mitochondrial electron transport chain component. This compound synthesized as the condensation of p-substituted benzoic acid and polyisoprenic moiety catalyzed by enzyme 4-hydroxybenzoate polyprenyltransferase (EC 2.5.1.39). In Plasmodium spp., this still uncharacterized. work, we expressed sequence falciparum PF3D7_0607500 gene (abbreviated PfCOQ2) in coq2Δ mutant strain Saccharomyces cerevisiae, studied functionality its product. open reading...