A5044437921- Advanced MRI Techniques and Applications
- Menopause: Health Impacts and Treatments
- Advanced Neuroimaging Techniques and Applications
- Estrogen and related hormone effects
- Cerebrovascular and Carotid Artery Diseases
- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Cancer-related cognitive impairment studies
- Alzheimer's disease research and treatments
- Stress Responses and Cortisol
- Metabolomics and Mass Spectrometry Studies
- Phytoestrogen effects and research
- Lanthanide and Transition Metal Complexes
- Multiple Sclerosis Research Studies
- Electron Spin Resonance Studies
- Mitochondrial Function and Pathology
- Biochemical effects in animals
- Neuroscience and Neuropharmacology Research
- Advanced NMR Techniques and Applications
- Atomic and Subatomic Physics Research
- Glioma Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Neural dynamics and brain function
- Enzyme Production and Characterization
Mayo Clinic
2020-2024
Mayo Clinic in Arizona
2020-2024
WinnMed
2024
Sağlık Bilimleri Üniversitesi
2021
University of Antwerp
2015-2021
Antwerp University Hospital
2018
Leiden University
2011-2015
Middle East Technical University
2003
T2-family acidic endoribonucleases are represented in all genomes. A physiological role for RNase T2 has yet to be defined metazoa. RNASET2 mutation humans is linked with a leukoencephalopathy that arises infancy characterized by cortical cysts and multifocal white matter lesions. We now show localization of within lysosomes. Further, we demonstrate loss rnaset2 mutant zebrafish results accumulation undigested rRNA lysosomes neurons the brain. using high field intensity magnetic resonance...
Detrimental inflammatory responses in the central nervous system are a hallmark of various brain injuries and diseases. With this study we provide evidence that lentiviral vector-mediated expression immune-modulating cytokine interleukin 13 (IL-13) induces an alternative activation program both microglia macrophages conferring protection against severe oligodendrocyte loss demyelination cuprizone mouse model for multiple sclerosis (MS). First, IL-13 mediated modulation induced lesions was...
Background Findings from Kronos Early Estrogen Prevention Study (KEEPS)-Cog trial suggested no cognitive benefit or harm after 48 months of menopausal hormone therapy (mHT) initiated within 3 years final menstrual period. To clarify the long-term effects mHT in early postmenopause, observational KEEPS Continuation reevaluated cognition, mood, and neuroimaging participants enrolled KEEPS-Cog its parent study approximately 10 completion. We hypothesized that women randomized to transdermal...
In vivo MRS is a non‐invasive measurement technique used not only in humans, but also animal models using high‐field magnets. enables the of metabolite concentrations as well metabolic rates and their modifications healthy animals disease models. Such data open way to deeper understanding underlying biochemistry, related disturbances mechanisms taking place during or prior symptoms tissue changes. this work, we focus on main preclinical 1 H, 31 P 13 C approaches study brain metabolism rodent...
Conventional MRI is frequently used during the diagnosis of multiple sclerosis but provides only little additional pathological information. Proton MRS (1H-MRS), however, biochemical information on lesion pathology by visualization a spectrum metabolites. In this study we aimed to better understand changes in metabolite concentrations following demyelination white matter. Therefore, cuprizone model, well-established mouse model mimic type III human demyelinating lesions. First, identified...
Abstract Background Findings from Kronos Early Estrogen Prevention Study (KEEPS)-Cog trial suggested no cognitive benefit or harm after 48 months of menopausal hormone therapy (mHT) initiated within three years menopause onset. Long-term effects mHT exposure during early postmenopause remain understudied. To clarify the long-term in postmenopause, observational KEEPS-Continuation reevaluated cognition, mood, and neuroimaging participants enrolled KEEPS-Cog its parent study KEEPS...
Abstract Objective This study aimed to determine long-term cardiometabolic effects of hormone therapies initiated within 3 years onset menopause after a 14-year follow-up participants the Kronos Early Estrogen Prevention Study (KEEPS). Methods KEEPS was multisite clinical trial that recruited recently menopausal women with good cardiovascular health for randomization oral conjugated equine estrogens (Premarin, 0.45 mg/d) or transdermal 17β-estradiol (Climara, 50 μg/d) both micronized...
The corpus callosum is the largest commissural fiber connecting left and right hemisphere of brain. Emerging evidence suggests that a variety abnormalities detected in microstructure this white matter can be an early event Alzheimer's disease (AD) pathology. However, little known about tissue characteristics these how evolve during AD progression. In study, we measured vivo magnetic resonance transverse relaxation times (T2) to longitudinally monitor changes integrity related myelination...
To establish regional T1 and T2 values of the healthy mouse brain at ultra-high magnetic field strength 17.6 T to follow changes with age.In vivo in C57BL/6J were followed age using multislice-multiecho sequence multiple spin echo saturation recovery variable repetition time sequence, respectively, 9.4 T. Gadolinium-tetra-azacyclo-dodecane-tetra-acetic acid phantoms used validate measurements. Student's t-test was compare mean relaxation values.A field-dependent decrease is shown validated...
Advanced MRS protocols improve data quality and reproducibility relative to vendor-provided protocols; however, they are challenging incorporate into the clinical workflow require local expertise for successful implementation. Here, we developed an automated advanced acquisition protocol at 3T facilitate of high-quality spectroscopic without expertise.First, a B0 shimming was selected automation by comparing 3 widely used algorithms (2 vendor FAST(EST)MAP). Next, voxel-based B1 calibrations...
Abstract INTRODUCTION Premenopausal bilateral oophorectomy (PBO) is associated with later‐life cognition, but the underlying brain changes remain unclear. We assessed impact of PBO and age on white matter integrity. METHODS Female participants regional diffusion tensor imaging (DTI) metrics fractional anisotropy (FA) mean diffusivity (MD) were included (22 < 40 years; 43 40‐45 39 46‐49 907 referents without 50 years). Linear regression models adjusted for apolipoprotein E ( APOE) genotype...
In vivo proton (1H) magnetic resonance spectroscopy (MRS) is a powerful noninvasive method which can measure Alzheimer’s disease (AD) related neuropathological alterations at the molecular level. AD biomarkers include amyloid-beta (Aβ) plaques and hyperphosphorylated tau neurofibrillary tangles. These be detected via postmortem analysis, but also in living individuals through positron emission tomography (PET) or biofluid of Aβ tau. This review offers an overview biochemical abnormalities by...
The present study was designed to examine which kind of memory: reference or working, better correlates with individual variation in rats' spatial learning abilities. To answer this question two groups rats were trained an arbitrary criterion a partially baited 12-arm radial maze under different experimental conditions: without allothetic cues. After 10 days break, examined the same conditions for memory retention. Within- and between-group length training criterion, frequency working errors...
Glutamate is the principal excitatory neurotransmitter in brain and at base of a wide variety neuropathologies, including epilepsy, autism, Fragile X, obsessive compulsive disorder. has also become target for novel drugs treatment fundamental research settings. However, much remains unknown on working mechanisms these effects chronic administration glutamatergic system. This study investigated two glutamate-modulating with imaging techniques to further clarify their future opportunities....
In vivo magnetic resonance spectroscopy is a powerful tool which can be applied non-invasively to monitor disease progression at molecular level in the brain of human patients with Alzheimers (AD) and transgenic mouse models AD. Application imaging (MRI) (MRS) AD makes it possible follow metabolic changes structural same time longitudinally. This review focuses on MRS studies highlights future impact techniques finding crucial biomarkers Keywords: Alzheimer's Disease, spectroscopy, models,...