A5065992735- Lipid metabolism and disorders
- Apelin-related biomedical research
- Hormonal Regulation and Hypertension
- FOXO transcription factor regulation
- Pancreatic function and diabetes
- Adipose Tissue and Metabolism
- Robot Manipulation and Learning
- Parallel Computing and Optimization Techniques
- Real-Time Systems Scheduling
- Natural Language Processing Techniques
- Protein Degradation and Inhibitors
- Signaling Pathways in Disease
- Lipid metabolism and biosynthesis
- Peroxisome Proliferator-Activated Receptors
- Sphingolipid Metabolism and Signaling
- Endoplasmic Reticulum Stress and Disease
- Cancer-related molecular mechanisms research
- Muscle Physiology and Disorders
- Liver Disease Diagnosis and Treatment
- Heat shock proteins research
- Diet, Metabolism, and Disease
- Distributed and Parallel Computing Systems
- Topic Modeling
University of California, Berkeley
2014-2021
National University of Kaohsiung
2016
Chronic glucocorticoid exposure is associated with the development of insulin resistance. We showed that glucocorticoid-induced resistance was attenuated upon ablation
Glucocorticoids contribute to adipocyte differentiation by cooperating with transcription factors, such as CCAAT/enhancer-binding protein β (C/EBPβ), stimulate of the gene encoding peroxisome proliferator-activated receptor (PPARγ), a master regulator adipogenesis. However, mechanism PPARγ regulation glucocorticoids, glucocorticoid (GR), and its coregulators is poorly understood. Here we show that two GR binding regions (GBRs) in mouse were responsive glucocorticoid, treatment 3T3-L1...
Angiopoietin-like 4 (Angptl4) is a glucocorticoid receptor (GR) primary target gene in hepatocytes and adipocytes. It encodes secreted protein that inhibits extracellular LPL promotes adipocyte lipolysis. In Angptl4 null mice, glucocorticoid-induced lipolysis hepatic steatosis are compromised. Markedly, insulin suppressed transcription. To unravel the mechanism, we utilized small molecules to inhibit signaling components found phosphatidylinositol 3-kinase Akt were vital for suppression...
Glucocorticoids promote lipolysis in white adipose tissue (WAT) to adapt energy demands under stress, whereas superfluous causes metabolic disorders, including dyslipidemia and hepatic steatosis. Glucocorticoid-induced requires the phosphorylation of cytosolic hormone-sensitive lipase (HSL) perilipin 1 (Plin1) lipid droplet by protein kinase A (PKA). We previously identified Pik3r1 (also called p85α) as a glucocorticoid receptor target gene. Here, we found that glucocorticoids increased HSL...
Chronic or excess glucocorticoid exposure causes lipid disorders such as hypertriglyceridemia and hepatic steatosis. Angptl4 (angiopoietin-like 4), a primary target gene of the receptor in hepatocytes adipocytes, is required for steatosis induced by synthetic dexamethasone. has also been shown to be dexamethasone-induced ceramide production. Here, we further examined role ceramide-mediated signaling dyslipidemia caused chronic exposure. Using stable isotope-labeling technique, found that...
Glucocorticoids and FoxO3 exert similar metabolic effects in skeletal muscle. gene expression was increased by dexamethasone (Dex), a synthetic glucocorticoid, both vitro vivo. In C2C12 myotubes the is due to, at least part, elevated rate of transcription. mouse gene, we identified three glucocorticoid receptor (GR) binding regions (GBRs): one being upstream transcription start site, −17kbGBR; two introns, +45kbGBR +71kbGBR. Together, these GBRs contain four 15-bp response elements (GREs)....
Chronic glucocorticoid exposure causes insulin resistance and muscle atrophy in skeletal muscle. We previously identified phosphoinositide-3-kinase regulatory subunit 1 (Pik3r1) as a primary target gene of receptors involved the glucocorticoid-mediated suppression action. However, vivo functions Pik3r1 remain unclear. Here, we generated striated muscle-specific knockout (MKO) mice treated them with dexamethasone (DEX), synthetic glucocorticoid. Treating wildtype (WT) DEX attenuated activated...
Named Entity Recognition has traditionally been a key task in natural language processing, aiming to identify and extract important terms from unstructured text data. However, notable challenge for contemporary deep-learning NER models identifying discontinuous entities, which are often fragmented within the text. To date, methods address Discontinuous have not explored using ensemble learning best of our knowledge. Furthermore, rise large models, such as ChatGPT recent years, shown...
The purpose of this paper is to study the task scheduling problem sets on multiprocessor systems. In set there are parallel tasks and sequential tasks. Parallel can not meet their deadlines if they executed by one unique thread. We propose Worst-Fit based Equal Slack (WFES) algorithm for deadline setting assignment. To derive a feasible assignment, we must select proper parallelization level from available options each task. Then will be split into several subtasks. Finally, generated...