Abstract Gluten and soy allergies are significant health concerns, particularly in individuals with celiac disease or sensitivity. While dietary sources of these allergens well-studied, their presence medicinal products remains under-explored. This study assessed the prevalence gluten soy-derived excipients 308 authorized for marketing Portugal. A systematic search Summary Product Characteristics (SmPC) database was conducted 108 analgesics antipyretics containing paracetamol, 85 NSAIDs...

Non-steroid anti-inflammatory drugs (NSAIDs) are a widely used therapeutic group in the world, and particularly Portuguese population.To compare NSAID's use by prescription self-medication acquisition to determine pattern of indication NSAIDs, their usage profile possible implications for patients' safety.A cross-sectional design was where individuals presenting at community pharmacy requesting NSAIDs during study period (one month) were invited answer face-to-face interview...

In a survey of levels acesulfame-K and aspartame in soft drinks light nectars, the intake these intense sweeteners was estimated for group teenage students. Acesulfame-K detected 72% drinks, with mean concentration 72 mg l(-1) found 92% samples 89 l(-1). When data on content were analysed according to flavour, cola had highest both 98 103 aspartame, respectively. For based mineral water, 62% samples, 82 77%, level 48 All nectars contained acesulfame-K, 128 80% 73 A frequency questionnaire,...

Abstract The use of lactose and cow milk protein (CMP) as potential allergens in pharmaceuticals their ability to cause allergic reactions remains a significant concern medicine. Lactose, common pharmaceutical excipient due its inert, inexpensive, stable properties, is found many prescription-only over-the-counter medications. However, despite widespread use, individuals with intolerance (LI) or allergy (CMPA) may experience adverse these excipients. This study investigated the prevalence...

Nowadays, food supplements are widely consumed, often without any medical supervision. In this study, 25 for weight loss, randomly purchased from five different suppliers in the European Union, were analysed by Wavelength Dispersive X ray Fluorescence spectrometry (WDXRF). The aim of study was risk assessment trace elements and mixture present loss. obtained Hazard Index (0.11) showed no potential non-carcinogenic effects to human health. However, since humans frequently exposed routes...

The pharmacokinetic parameters of vancomycin in a neonatal population have been characterized to enable development optimum dosage guidelines for intensive-care units and examine the relationship between these various demographic, developmental clinical factors which might be associated with changes kinetic profile vancomycin. Forty-four infants (twenty-five males nineteen females) suspected or proven Gram-positive infection who received intravenous October 1993 December 1996 were included...

This work demonstrates that an analytical method based on wavelength dispersive X-ray fluorescence spectrometry has acceptable degree of linearity, precision and accuracy in a given range, which make it suitable for the purpose determining Cu, Zn, Fe Cr impurities final drug products.

Food allergies are a growing concern, especially in Western societies and can dramatically impact the quality of life affected individuals. In recent years, various food allergens have been introduced into oral care industry to improve product properties provide best possible treatment. Since small doses may be sufficient trigger allergic reactions, non-discrimination sources certain excipients composition compromise patient's health. Therefore, knowledge awareness among health professionals...

Abstract Warfarin is a 4-hydroxycoumarin anticoagulant drug used for the prevention and management of thromboembolic vascular diseases. It acts through inhibition vitamin K-dependent transcarboxylation reactions that convert precursors clotting factors into their active form. Appropriate use warfarin requires patient monitoring dosage adjustments, to ensure its safety efficacy. The aim this work was clarify relationship between traditional (prothrombin time, usually expressed as...

The heterogeneous nature of the kraft pulping wood is experimentally demonstrated in this paper, and a new methodology for investigation presented. strategy proposed here enables measurement alkali lignin concentrations liquor, both inside outside chips. With procedure, it possible to independently determine, entrapped free liquors, time histories as well total dissolved solids, which are direct result mass transfer chemical reactions that take place during process. influence chip thickness...

Introdução: Muitos fármacos podem induzir fotodermatoses (Blakely et al., 2019; Hofmann & Weber, 2021), com manifestações clínicas de difícil diagnóstico. No caso dos idosos polimedicados, há maior probabilidade isso acontecer, sendo importante identificar as terapêuticas fotossensibilizantes e prevenir aplicando protetor solar. Objetivos: Foi realizado um estudo transversal para avaliar o potencial fotossensibilizante da terapêutica idosos, em ambiente familiar, mais 65 anos, a tomar...

Introdução: O consumo de suplementos alimentares (SA) tem aumentado em todo o mundo, com uma prevalência aproximada 30% Portugal, sobretudo os SA contendo vitaminas e minerais. selénio (Se) zinco (Zn) são micronutrientes essenciais às funções fisiológicas, mas doses excessivas podem desencadear efeitos adversos: Zn pode causar náuseas, vómitos, letargia, anemia tonturas, excesso Se provocar neuropatia periférica, fadiga, irritabilidade alterações no cabelo unhas. Objetivos: Este estudo...

Objective : The aim of our work was to define the kinetic profile carbamazepine (CBZ), in order improve on dosing schedules through a Bayesian approach. Method: Carbamazepine dose/steady-state trough concentrations data pairs and associated information were collected retrospectively population adult epileptic patients. Results: Fifty patients (index population) with two or more available (total 174 determinations) met inclusion criteria. Patients taking CBZ (200–1800 mg/day) mono-...

Almeida, A. M.; Canas, N.; Costa, I. Caramona, M. Falcão, C. Author Information

Introduction Food allergy is an increasing health care concern, being cow’s milk protein (CMPA) the most prevalent food in infants and young children (2–7.5%) [1 Manuyakorn W, Tanpowpong P. Cow other common allergies intolerances. Paediatr Int Child Health. 2019;39(1):32–40.[Taylor & Francis Online], [Web of Science ®] , [Google Scholar],2 Mousan G, Kamat D. Cow's allergy. Clin Pediatr. 2016;55(11):1054–1063.[Crossref], [PubMed], Scholar]]. CMPA symptoms involve mostly skin, gastrointestinal...

People aged 65+ are generally polymedicated. In this age group, it is important to be aware of the potential for drug-induced photosensitivity. Sunscreen use an effective way prevent sun damage skin. Our study aimed evaluate sunscreen habits in 104 non-institutionalized elderly people 65 years and older taking/use photosensitizing medications. It was concluded that all but one take drugs do not regularly. Although therapies were prescribed or advised by health professionals, virtually stated...

Cyclic nucleotide phosphodiesterases (PDEs) are enzymes that regulate the cellular levels of second messengers adenosine 3´5´-cyclic monophosphate (cAMP) and guanosine (cGMP) by controlling their rates degradation. The increase intracellular cAMP cGMP, through PDE inhibition, represents a useful strategy for eliciting variety pharmacological effects with important clinical applications. The different tissue distribution large diversity in structure, regulation function among PDE isozymes,...

Almeida, A. M.; Costa, I. Leitão, F.; Santos, J.; Caramona, M. Falcão, C. Author Information

Introduction: Adequate vitamins consumption is indispensable for the maintenance of health and to prevent disease. Both poor overdose intakes may result in adverse effects [Citation1]. Recommended Daily Allowance (RDA) average daily level intake sufficient meet nutrient requirements nearly all (97-98%) healthy individuals [Citation2]; Tolerable Upper Intake Level (UL) maximum total chronic a judged be unlikely pose risk humans [Citation3]. Owing ability fat-soluble accumulate liver adipose...