A5001937405- Aortic aneurysm repair treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Diseases and Immunity
- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Cardiac, Anesthesia and Surgical Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Cells and Metastasis
- Colorectal Cancer Treatments and Studies
- Gastric Cancer Management and Outcomes
- Aortic Disease and Treatment Approaches
- Pediatric Hepatobiliary Diseases and Treatments
- Renal and Vascular Pathologies
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Hormonal Regulation and Hypertension
- Metastasis and carcinoma case studies
- Peripheral Artery Disease Management
- Multiple and Secondary Primary Cancers
- Renal Transplantation Outcomes and Treatments
- Cancer Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Ocular Surface and Contact Lens
- Biliary and Gastrointestinal Fistulas
Karolinska Institutet
2014-2025
Karolinska University Hospital
2011-2024
Integrated Cardio Metabolic Centre
2024
Hôpital André Mignot
1989
•CCA was diagnosed in 2% of patients with PSC during a 5-year follow-up.•The risk hepatobiliary malignancy associated severe biliary strictures.•Yearly MRI cancer surveillance failed to provide long-term survival.•Individualised strategies for early diagnosis CCA are warranted. Background & AimsThe evidence tumour primary sclerosing cholangitis (PSC) is scarce. In this study, we aimed prospectively evaluate cholangiocarcinoma (CCA) yearly cholangiopancreatography (MRI/MRCP) nationwide...
Liver transplantation (LTX) using donors after controlled circulatory death (cDCD) is associated with poorer graft survival and increased incidence of nonanastomotic biliary strictures (NASs) compared to livers procured from brain-dead (DBD). The use normothermic regional perfusion (NRP) during cDCD procurement may improve posttransplant outcomes reduce the NAS. In Sweden, LTX was introduced through a national pilot protocol mandatory NRP. This study aims evaluate outcome period. Donor...
A perimetastatic capsule is a strong positive prognostic factor in liver metastases, but its origin remains unclear. Here, we systematically quantify the capsule's extent and cellular composition 263 patients with colorectal cancer metastases to investigate clinical significance origin. We show that survival improves proportionally increasing encapsulation decreasing tumor-hepatocyte contact. Immunostaining reveals gradual zonation of capsule, transitioning from benign-like NGFR
Primary sclerosing cholangitis (PSC) is the classical hepatobiliary manifestation of inflammatory bowel disease (IBD) and a lead indication for liver transplantation (LT) in western world. In this article, we present Consensus Statement on LT practice, developed by dedicated Guidelines' Taskforce European Society Organ Transplantation (ESOT). The overarching goal to provide practical guidance commonly debated topics, including indications timing LT, management bile duct stenosis patients...
There is no medical treatment to prevent abdominal aortic aneurysm (AAA) growth and rupture, both of which are linked smoking. Our objective was map the tunica-specific pathophysiology AAA with consideration intraluminal thrombus, age, sex, subsequently identify mechanisms were smoking diameter rate. Approach Results: Microarray analyses performed on 246 samples from 76 patients 13 controls. In media adventitia, there 5889 2701 differentially expressed genes, respectively. Gene sets related...
BackgroundDespite more than 50 years of research and parallel improvements in hepatology oncology, there is still today neither a treatment to prevent disease progression primary sclerosing cholangitis (PSC), nor reliable early diagnostic tools for the associated hepatobiliary cancers. Importantly, limited understanding underlying biological mechanisms PSC its natural history not only affects identification new drug targets but implies lack surrogate markers that hampers design clinical...
Abstract Background Resection outcomes for perihilar cholangiocarcinoma differ between Western and Eastern centres, but reasons behind these disparities remain unclear. This study aimed to compare current a an expert centre identify prognostic factors. Methods Patients who underwent hepatobiliary resection 2010 2022 at Karolinska University Hospital (Stockholm, Sweden) Cancer Institute (Tokyo, Japan) were retrospectively included. Primary outcome was overall survival. Secondary disease-free...
The occurrence of colorectal liver metastases (CRLM) impairs prognosis, yet long-term survival can be achieved by enabling resection. This study aims to describe factors associated with conversion therapy leading surgery and treatment outcome.A retrospective cohort was conducted including all patients CRLM discussed at multidisciplinary team conference Karolinska University Hospital, Stockholm, Sweden, from 2013 2018. Factors outcome following were analysed logistic regression analyses.Out...
BackgroundAbdominal aortic aneurysms (AAAs) primarily affect elderly men. The effect of sex on aneurysm development has been associated with the effects hormones through mechanisms that are not fully understood. present study examined association between levels and occurrence AAAs in men.MethodsA prospective case-control was conducted 452 men aged 65 years participating screening for from 2013 to 2019. Of men, 230 had an AAA 222 diameter <30 mm (control group). Questionnaires blood samples...
Abdominal aortic aneurysms (AAAs) in women differ some important aspects from those men. The lower prevalence rate, higher rupture rate and potentially increased growth with AAA suggest gender to be of importance for aneurysm development progression. aim the study was analyze wall properties respect synthesis destruction elastin men AAA, without an intraluminal thrombus.Patient characteristics biopsies were collected all (n = 14) treated open repair 2008-2012, similar diameter age 23) during...
Metastatic spread of colorectal cancer to the liver impacts prognosis. Advances in chemotherapy have resulted increased resectability rates and thereby improved survival patients with metastases (CRLM). However, criteria are needed ensure that selected for hepatic resection benefit from invasive therapy. The study aimed construct a predictive model overall (OS) CRLM, based on preoperatively available information.The retrospective cohort reviewed all CRLM discussed at multidisciplinary team...
BACKGROUND:Solid pseudopapillary neoplasm (SPN) of the pancreas, which predominantly affects young women, is an uncommon condition with low malignant potential. It often asymptomatic. This tumor has a metastatic rate and good prognosis in contrast to other pancreatic tumors. Approximately 14% SPNs develop liver metastasis, but for features metastasis been reported occur over 55% cases. Complete surgical resection treatment choice increasing survival recurrent disease. When impossible,...
For some patients undergoing resection under the suspicion of a perihilar cholangiocarcinoma (pCCA), postoperative diagnosis may differ from preoperative diagnosis. While finding benign bile duct stricture is known to affect 3-15% patients, less has been described about consequences other biliary tract cancers postoperatively. This study compared pre- and diagnoses, risk characteristics, outcomes after surgery for suspected pCCA.Retrospective single-center study, Karolinska University...
Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasing in prevalence globally. MASLD associated with an increased rate of comorbidities, including cardiovascular disease, cirrhosis, and hepatocellular carcinoma (HCC). While the link between HCC well known, potential association biliary tract cancer, cholangiocarcinoma (CCA) gallbladder cancer (GBC), less certain. To evaluate whether individuals are at risk developing CCA compared to general population, we...
Background Abdominal aortic aneurysm (AAA) is a potentially life-threatening disease, and until today there no other treatment available than surgical intervention. Dipeptidyl peptidase-4 (DPP4)-inhibitors, used clinically to treat type 2 diabetes, have in murine models been shown attenuate formation decrease wall matrix degradation, inflammation apoptosis. Our aim was investigate if DPP4 present, active differentially expressed human AAA. Methods results gene expression elevated both media...
Abstract Aim Surgical treatment of colorectal cancer with synchronous liver metastases (SCRLM) can follow three different strategies regard to the timing resection. The aim this study was describe selection surgical strategy, focusing on differences between colon and rectal SCRLM, postoperative morbidity/mortality survival. Method This a retrospective population‐based patients SCRLM registered in Swedish Colorectal Cancer Registry Stockholm/Gotland region during 2010–2017 treated resection...
Unresectable colorectal liver metastases (CRLM) is a condition with poor prognosis. A recent treatment alternative improving survival in patients unresectable CRLM, has emerged the introduction of transplantation (LT), yet not uncontroversial current organ shortage. This study aimed to retrospectively investigate potential declined donors acceptable risk as graft and CRLM recipients.All central Sweden all discussed at multidisciplinary team conference Karolinska University Hospital, January...
Background and objective: Gallbladder cancer (GBC) is a rare malignancy in the Nordic countries no common treatment guidelines exist. This study aimed to characterize current diagnostic strategies disclose differences these strategies. Methods: was survey with cross-sectional questionnaire of all 19 university hospitals providing curative-intent surgery for GBC Sweden, Norway, Denmark, Finland. Results: In except neoadjuvant/downstaging chemotherapy used patients. T1b T2, majority centers...