A5039067680- Traumatic Brain Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrest and Resuscitation
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Meta-analysis and systematic reviews
- Intensive Care Unit Cognitive Disorders
- Drug-Induced Hepatotoxicity and Protection
- Scoliosis diagnosis and treatment
- Musculoskeletal pain and rehabilitation
- Sepsis Diagnosis and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- S100 Proteins and Annexins
- Spinal Cord Injury Research
- Spinal Fractures and Fixation Techniques
- Adolescent and Pediatric Healthcare
- Neuroinflammation and Neurodegeneration Mechanisms
- Pelvic and Acetabular Injuries
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and healthcare impacts
- Renal Transplantation Outcomes and Treatments
- Gastrointestinal motility and disorders
- CAR-T cell therapy research
University of British Columbia
2020-2025
King Abdulaziz University
2025
Children's Hospital of Eastern Ontario
2025
University of Toronto
2025
McMaster Children's Hospital
2025
Hospital for Sick Children
2025
University of Alberta
2025
SickKids Foundation
2025
International Collaboration On Repair Discoveries
2020-2024
Toronto Metropolitan University
2024
Abstract Studies on severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) suggest a protective effect of anti-A antibodies against viral cell entry that may hold relevance for SARS-CoV-2 infection. Therefore, we aimed to determine whether ABO blood groups are associated with different severities COVID-19. We conducted multicenter retrospective analysis and nested prospective observational substudy critically ill patients collected data pertaining age, sex, comorbidities, dates symptom...
Traumatic spinal cord injury (SCI) is highly heterogeneous, and tools to better delineate pathophysiology recovery are needed. Our objective was profile the response of 2 biomarkers, neurofilament light (NF-L) glial fibrillary acidic protein (GFAP), in serum CSF patients with acute SCI evaluate their ability objectively characterize severity predict neurologic recovery.Blood samples were obtained from prospectively enrolled through days 1-4 postinjury, concentration NF-L GFAP quantified...
Rationale: Secondary brain hypoxia portends significant mortality in ischemic diseases; yet, our understanding of hypoxic injury (HIBI) pathophysiology humans remains rudimentary. Objective: To quantify the impact secondary on to neurovascular unit patients with HIBI. Methods and Results: We conducted a prospective interventional study invasive neuromonitoring 18 post–cardiac arrest The partial pressures tissue O 2 (PbtO ) intracranial pressure were directly measured via intraparenchymal...
To provide an objective characterization of acute neurologic injury in critically ill patients with coronavirus disease 2019.Prospective observational study. Demographics, comorbidities, and daily clinical physiologic laboratory data were collected. Plasma levels neurofilament-light chain, total tau, ubiquitin carboxy-terminal hydrolase L1, glial fibrillary acidic protein measured. The primary outcome was delirium defined by the Intensive Care Delirium Screening Checklist (scale 1-8)....
Coronavirus disease 2019 (COVID-19) severity appears to parallel the host immune response, with a subset of patients developing COVID-19 cytokine storm syndrome (CSS).1 Serum inflammatory cytokines are elevated in COVID-192-5 and interleukin 6 (IL-6) play central role COVID-19-related CSS.6-8 Based on success IL-6-receptor blockade for chimeric antigen receptor T-cell therapy associated release (CAR-T cell CRS), similar strategies using tocilizumab being investigated COVID-19. However, early...
Obesity is a complex, chronic, stigmatized disease whereby abnormal or excess body fat may impair health increase the risk of medical complications, and can reduce quality life shorten lifespan in children families. We developed this guideline to provide evidence-based recommendations on options for managing pediatric obesity that support shared decision-making among living with obesity, their families, care providers. followed Grading Recommendations Assessment, Development Evaluation...
The majority of coronavirus disease 2019 mortality and morbidity is attributable to respiratory failure from severe acute syndrome 2 infection. pathogenesis underpinning 2019-induced may be a dysregulated host immune response. Our objective was investigate the pathophysiological relationship between proinflammatory cytokines in 2019.Multicenter prospective observational study.ICU.Critically ill patients with noncoronavirus critically (ICU control group).Daily measurement serum inflammatory...
Blood biomarkers have the potential to transform diagnosis and prognosis for multiple neurological indications. Establishing normative data is a critical benchmark in analytical validation process. Normative are important children as little known about how brain development may impact biomarkers. The objective of this study generate pediatric reference intervals (RIs) serum neurofilament light (NfL), an axonal marker, glial fibrillary acidic protein (GFAP), astrocytic marker.
Abstract INTRODUCTION This study investigates the effect of apolipoprotein E ( APOE ) genotype on neurology plasma biomarkers in cognitively healthy Super‐Seniors. METHODS Three hundred seventy specimens from Super‐Senior participants ≥ 85 years old, who have never been diagnosed with dementia, cancer, diabetes, cardiovascular, or major pulmonary disease, were analyzed Quanterix Simoa HD‐X analyzer using commercial Neurology 4‐plex and phosphorylated tau (p‐tau)181 assays. RESULTS Eighty...
Abstract Background Glial fibrillary acidic protein (GFAP) has emerged as a promising fluid biomarker for several neurological indications including traumatic brain injury (TBI), leading cause of death and disability worldwide. In humans, serum or plasma GFAP levels can predict abnormalities hemorrhage on computed tomography (CT) scans magnetic resonance imaging (MRI). However, assays to quantify in preclinical models are not yet available. Methods We developed validated novel sensitive...
A major obstacle for translational research in acute spinal cord injury (SCI) is the lack of biomarkers that can objectively stratify severity and predict outcome. Ubiquitin C-terminal hydrolase L1 (UCH-L1) a neuron-specific enzyme shows promise as diagnostic biomarker traumatic brain (TBI), but has not been studied SCI. In this study, cerebrospinal fluid (CSF) serum samples were collected over first 72-96 h post-injury from 32 SCI patients who followed prospectively to determine...
Abstract Developing objective measures to diagnose sport-related concussion (SRC) is a top priority, particularly in the pediatric context, given vulnerability of developing brain. While advances SRC blood biomarkers are being made adult populations, less data available for adolescents. Clinical validation post-SRC will first require investigation healthy uninjured state. Further, rapid pubertal changes during adolescence may implicate possible interactions with circulating sex hormones and...
Importance Blood-based biomarkers may clarify underlying neuropathology and potentially assist in clinical management of adolescents with sport-related concussion (SRC). Objective To investigate the association between SRC plasma adolescents. Design, Setting, Participants Prospective cohort study Canadian sport clinic settings (Surveillance High Schools Community Sport to Reduce Concussions Their Consequences study; September 2019 November 2022). were a convenience sample 849 adolescent...
Traumatic brain injury (TBI) is an established risk factor for neurodegenerative diseases. In this study, we used the Closed Head Injury Model of Engineered Rotational Acceleration (CHIMERA) to investigate effects a single high-energy TBI in rTg4510 mice, mouse model tauopathy. Fifteen male mice (4 mo) were impacted at 4.0 J using interfaced CHIMERA and compared sham controls. Immediately after injury, showed significant mortality (7/15; 47%) prolonged duration loss righting reflex. At 2 mo...
The COVID-19 pandemic continues to challenge the capacities of hospital ICUs which currently lack ability identify prospectively those patients who may require extended management. In this study 90 ICU patients, we evaluated serum levels four cytokines (IL-1β, IL-6, IL-10 and TNFα) as well standard clinical laboratory measurements. On 42 these (binned into Initial Replication Cohorts), further performed CyTOF-based deep immunophenotyping peripheral blood mononuclear cells with a panel 38...
<h3>Objective</h3> Examine plasma t-tau, NFL, and GFAP levels in serial samples following interval exercise, while considering age, sex, sleep, assess agreement between serum biomarker concentrations. <h3>Design</h3> Randomized-crossover cohort. <h3>Setting</h3> UCalgary Laboratory. <h3>Participants</h3> Ten healthy participants were recruited from the community (ages 19–26; 7:3/female:male). Participants excluded if prior diagnosed concussion or metabolic disease, not recreationally active,...
<h3>Objective</h3> To characterize levels of plasma GFAP, NF-L, UCH-L1, T-tau, and p-tau181 in healthy youth athletes considering the influence previous concussion, age, sex, menstrual cycle stage, sex hormone concentrations. <h3>Design</h3> Cohort study. <h3>Setting</h3> Canadian high-school community sport settings. <h3>Participants</h3> Healthy participating SHRed Concussions study (n=149, 48% female, ages 11–17). <h3>Assessment Risk Factors</h3> Previous concussion (Yes/No), age (years),...
<h3>Objective</h3> To investigate agreement between plasma biomarker measurements run in duplicate and explore the precision of statistical modelling approaches using all replicate data vs standard practice sample means >20%CV exclusion. <h3>Design</h3> Cohort study. <h3>Setting</h3> Canadian high-school community sport settings. <h3>Participants</h3> Healthy youth athletes participating SHRed Concussions study (n=149, 48% female, ages 11–17). <h3>Assessment Risk Factors</h3> Previous...
<p>Mild traumatic brain injury (mTBI) is often accompanied by chronic pain-related disability, but the underlying mechanisms require further understanding. Here, I examine relations among domains of executive functioning (EF) with pain catastrophizing, depression, and anxiety. Moreover, assess extent to which EF uniquely contributes catastrophizing disability. Participants were adults mTBI who underwent a naturalistic neuropsychological assessment in community clinic. revealed moderate...
<p>Mild traumatic brain injury (mTBI) is often accompanied by chronic pain-related disability, but the underlying mechanisms require further understanding. Here, I examine relations among domains of executive functioning (EF) with pain catastrophizing, depression, and anxiety. Moreover, assess extent to which EF uniquely contributes catastrophizing disability. Participants were adults mTBI who underwent a naturalistic neuropsychological assessment in community clinic. revealed moderate...
Advancing research on fluid biomarkers associated with sport-related concussion (SRC) highlights the importance of detecting low concentrations using ultrasensitive platforms. However, common statistical practices may overlook replicate errors and specimen exclusion, emphasizing need to explore robust modeling approaches that consider all available data for comprehensive understanding sample variation inferences.To evaluate impact error different biostatistical SRC biomarker...
Purpose: Hospitalizations and length of stay are quickly becoming an important economic, reimbursement, quality care parameter. The Healthcare Costs Utilization Project (HCUP) data have shown a steady increase in hospitalizations cost hospitalization for cirrhotics over the past decade. One area that has not varied is (LOS) at approximately five days per overt hepatic encephalopathy (HE) admission. purpose this abstract to retrospectively investigate LOS patients hospitalized with HE....
Abstract The COVID-19 pandemic continues to challenge the capacities of hospital ICUs which currently lack ability identify prospectively those patients who may require extended management. In this study 90 ICU patients, we evaluated serum levels four cytokines (IL-1β, IL-6, IL-10 and TNFα) as well standard clinical laboratory measurements. On 42 these (binned into Initial Replication Cohorts), further performed CyTOF-based deep immunophenotyping peripheral blood mononuclear cells with a...