A5054731979- Opioid Use Disorder Treatment
- Substance Abuse Treatment and Outcomes
- Cannabis and Cannabinoid Research
- Prenatal Substance Exposure Effects
- Diet and metabolism studies
- Meta-analysis and systematic reviews
- Innovations in Medical Education
- Colorectal Cancer Screening and Detection
- Pharmaceutical Practices and Patient Outcomes
- Pain Management and Placebo Effect
- Suicide and Self-Harm Studies
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Pharmacology and Obesity Treatment
- Schizophrenia research and treatment
- Health Systems, Economic Evaluations, Quality of Life
- Colorectal Cancer Surgical Treatments
- Healthcare professionals’ stress and burnout
- Health Policy Implementation Science
- Sports injuries and prevention
- Cardiac Arrest and Resuscitation
- COVID-19 diagnosis using AI
- HIV, Drug Use, Sexual Risk
- Food Allergy and Anaphylaxis Research
- Knee injuries and reconstruction techniques
McMaster University
2015-2024
Health Sciences Centre
2024
Albert Einstein College of Medicine
2024
Montefiore Medical Center
2024
Impact
2020-2023
Delaware County Memorial Hospital
2021
St Michael's Hospital
2021
University of Toronto
2021
St. Joseph’s Healthcare Hamilton
2021
McGill University
2021
KEY POINTS Obesity is a complex chronic disease in which abnormal or excess body fat (adiposity) impairs health, increases the risk of long-term medical complications and reduces lifespan.[1][1] Epidemiologic studies define obesity using mass index (BMI; weight/height2), can stratify
Food allergy, in particular peanut is a growing concern Western countries. The prevalence of allergy to peanut, which currently stands at 1.4%, nearly tripled between 1997 and 2008. Allergic sensitization particularly difficult process study as it clinically silent. We sought identify key pathways mediators critically involved the induction allergic peanut.Comprehensive metabolomics analysis with liquid chromatography-mass spectrometry was used detect metabolite changes mice (C57BL/6)...
There is a significant interindividual variability in treatment outcomes methadone maintenance (MMT) for opioid use disorder (OUD). This prospective cohort study examines the impact of comorbid psychiatric disorders on continued illicit patients receiving MMT OUD.Data were collected from 935 outpatient clinics between June 2011 and 2015. Using linear regression analysis, we evaluated having during MMT, adjusting important confounders. The main outcome measure was percentage opioid-positive...
The novel coronavirus disease 2019 (COVID-19) pandemic has now surpassed 1 million documented cases globally. forced social distancing measures and cancellation of nonessential services at an unprecedented scale. COVID-19, caused by the viral pathogen severe acute respiratory syndrome 2 (SARS-CoV-2), permeated communities unparalleled rates. Within just a few months after initial documentation in December 2019, World Health Organization (WHO) declared pandemic. Prior to this, however, WHO...
Concomitant opioid abuse is a serious problem among patients receiving methadone maintenance treatment (MMT) for use disorder. This an exploratory study that aims to identify predictors of the length time patient MMT disorder remains abstinent (relapse-free).Data were collected from 250 enrolled in addiction clinics across Southern Ontario. The impact certain clinical and socio-demographic factors on outcome (time until relapse) was determined using Cox proportional hazard model.History...
Opioid use disorder (OUD) affects approximately 21.9 million people worldwide. This study aims to determine the association between age of onset opioid and comorbid disorders, both physical psychiatric, in patients receiving methadone maintenance treatment (MMT) for OUD. Understanding this may inform clinical practice about important prognostic factors on MMT, enabling clinicians identify high-risk patients.This includes data collected June 2011 August 2016 Genetics Addiction research...
Abstract Background With the ongoing opioid crisis and policy changes regarding legalization of cannabis occurring around world, it is necessary to consider use in context disorder (OUD) its treatment. We aimed examine (1) past-month patients with OUD, (2) self-reported cannabis-related side effects craving, (3) association between specific characteristics during treatment users. Methods Participants receiving pharmacological for OUD ( n = 2315) were recruited from community-based addiction...
Opioid use has reached an epidemic proportion in Canada and the United States that is mostly attributed to excess availability of prescribed opioids for pain. This opioid led increase prevalence disorder (OUD) requiring treatment. The most common treatment recommendations include medication-assisted (MAT) combined with psychosocial interventions. Clinical trials investigating effectiveness MAT, however, have a limited focus on measures overlook patient-important outcomes. Despite patients...
Existing methods of measuring effectiveness pharmacological treatment for opioid use disorder (OUD) are highly variable. Therefore, understanding patients' goals is an integral part patient-centred care. Our objective to explore whether align with a frequently used clinical outcome, abstinence. Triangulation mixed-methods design. We collected prospective data from 2030 participants who were receiving methadone or buprenorphine-naloxone diagnosis OUD in order meet study inclusion criteria....
The opioid use disorder (OUD) crisis in North America has become "an epidemic within a pandemic" the context of COVID-19 virus. We aimed to explore association between pandemic and changes patterns among patients receiving treatment for OUD.
Nonalcoholic Fatty Liver Disease (NAFLD) is a chronic progressive illness with spectrum of disease severity from steatosis to end-stage liver disease. Emerging evidence suggests total serum bilirubin levels are inversely related the prevalence metabolic syndrome including NAFLD. We investigated effects on all-cause and cause-specific mortality stratified by NAFLD status.We used third National Health Nutrition Examination Survey Cohort (1988-1994) linked dataset through 2019. Cox-regression...
Cannabis is the most commonly used illicit drug. In general population, its use has been linked to a heightened propensity for suicidal behavior (SB). We hypothesize that this association varies in patients with psychiatric disorders. SB known vary by sex and therefore an investigation of cannabis' must consider differences. The purpose study investigate between cannabis suicide attempts men women merged data collected two studies based Ontario, Canada (n = 985). employed multivariable...
POINTS CLÉS L'obésité est une maladie chronique complexe dans laquelle la graisse corporelle anormale ou excessive (adiposité) nuit à santé, augmente le risque de complications médicales long terme et réduit durée vie[1][1]. Les études épidémiologiques définissent l'obé