A5070265721- Opioid Use Disorder Treatment
- Substance Abuse Treatment and Outcomes
- Cannabis and Cannabinoid Research
- Prenatal Substance Exposure Effects
- Mental Health Treatment and Access
- COVID-19 and Mental Health
- Child and Adolescent Psychosocial and Emotional Development
- Suicide and Self-Harm Studies
- Schizophrenia research and treatment
- Child and Adolescent Health
- Alcohol Consumption and Health Effects
- Neurotransmitter Receptor Influence on Behavior
- Healthcare Policy and Management
- Alcoholism and Thiamine Deficiency
- Poisoning and overdose treatments
- Emergency and Acute Care Studies
- Religion, Spirituality, and Psychology
- Pain Management and Opioid Use
- Health disparities and outcomes
- Statistical Methods and Bayesian Inference
- Psychedelics and Drug Studies
- Telemedicine and Telehealth Implementation
- Eating Disorders and Behaviors
- Nerve injury and regeneration
- Epilepsy research and treatment
Children's Hospital of Eastern Ontario
2023-2025
Impact
2020-2025
McMaster University
2016-2025
University of Ottawa
2022-2025
Delaware County Memorial Hospital
2021
There is a significant interindividual variability in treatment outcomes methadone maintenance (MMT) for opioid use disorder (OUD). This prospective cohort study examines the impact of comorbid psychiatric disorders on continued illicit patients receiving MMT OUD.Data were collected from 935 outpatient clinics between June 2011 and 2015. Using linear regression analysis, we evaluated having during MMT, adjusting important confounders. The main outcome measure was percentage opioid-positive...
Background Individuals with opioid use disorder (OUD) have a high prevalence of co-occurring mental health disorders; however, there exists little information on service for this population. We aimed to determine the non-substance use-related emergency department (ED) visits, hospitalizations, and outpatient physician visits individuals receiving treatment OUD over one year. also explored individual-level characteristics associated care estimated costs care. Methods linked observational...
Bayesian analyses offer a robust framework for integrating data from multiple sources to better inform population-level estimates of disease prevalence. This methodological approach is particularly suited instances where observational studies linked administrative health records, with the capacity advance our understanding psychiatric disorders. The objective paper was provide an introductory overview and tutorial on analysis primary in mental research. We provided: (i) statistics, (ii)...
Background Vaping is increasing in popularity. Vape products are offered a wide variety and promise to reduce harms associated with cigarette smoking, among other claims. The motivations for vaping patients substance use disorder largely unknown. Aims To describe perceptions regarding opioid (OUD) who vape. Method A convergent mixed-methods study design was used, individual, semi-structured interviews were conducted 41 individuals OUD receiving medication also vaped. An inductive data-driven...
Abstract Background With the ongoing opioid crisis and policy changes regarding legalization of cannabis occurring around world, it is necessary to consider use in context disorder (OUD) its treatment. We aimed examine (1) past-month patients with OUD, (2) self-reported cannabis-related side effects craving, (3) association between specific characteristics during treatment users. Methods Participants receiving pharmacological for OUD ( n = 2315) were recruited from community-based addiction...
Importance Data suggest that the opioid crisis in North America has recently been reflected opioid-related mortality among youths. Despite recommendation for its use, youths encounter barriers to accessing OAT, including stigma, burden of witnessed dosing, and lack availability youth-oriented services prescribers comfortable treating this population. Objective To compare rates agonist treatment (OAT) between aged 15 24 years adults 25 44 Ontario, Canada, over time. Design, Setting,...
Abstract Background Social functioning (SF), the ability to engage with life and fulfill roles may be a salient “patient important outcome” in addiction treatment. It is not known if medication-assisted treatment (MAT) impacts SF opioid use disorder (OUD). There growing evidence suggest that men women are impacted differently by OUD. This study largest date sex differences OUD explore associations between MAT SF. Methods Data were collected from 2736 participants OUD, enrolled for varying...
<h3>Importance</h3> In the literature on opioid use disorder (OUD), abstinence is used as an outcome measure for individuals receiving medication-assisted treatment (MAT), without consideration of patient-reported goals (PRGs). <h3>Objectives</h3> To identify common PRGs youths MAT OUD and assess whether these patients achieve their stated goals. <h3>Design, Setting, Participants</h3> This prospective cohort study examined data from 152 aged 16 to 25 years (noninclusive) recruited between...
Opioid use has reached an epidemic proportion in Canada and the United States that is mostly attributed to excess availability of prescribed opioids for pain. This opioid led increase prevalence disorder (OUD) requiring treatment. The most common treatment recommendations include medication-assisted (MAT) combined with psychosocial interventions. Clinical trials investigating effectiveness MAT, however, have a limited focus on measures overlook patient-important outcomes. Despite patients...
Due to the loss of tolerance opioids during medication-assisted treatment (MAT), this period may represent a time heightened risk for overdose. Identifying factors associated with increased overdose is therefore paramount improving outcomes. We aimed determine prevalence opioid overdoses in patients receiving MAT. Additionally, we explored MAT and association between length enrolled overdose.Data were collected prospectively from 2360 participants outpatient Ontario, Canada. Participants...
Abstract Background and Objectives Substance use disorders are highly prevalent among individuals with psychotic associated negative outcomes. This study aims to explore differences in characteristics treatment outcomes for when compared other nonpsychotic psychiatric enrolled opioid disorder (OUD). Methods Data were collected from a prospective cohort of 415 outpatient methadone maintenance (MMT). Psychiatric comorbidity was assessed using the Mini-International Neuropsychiatric Interview....
Existing methods of measuring effectiveness pharmacological treatment for opioid use disorder (OUD) are highly variable. Therefore, understanding patients' goals is an integral part patient-centred care. Our objective to explore whether align with a frequently used clinical outcome, abstinence. Triangulation mixed-methods design. We collected prospective data from 2030 participants who were receiving methadone or buprenorphine-naloxone diagnosis OUD in order meet study inclusion criteria....
The opioid use disorder (OUD) crisis in North America has become "an epidemic within a pandemic" the context of COVID-19 virus. We aimed to explore association between pandemic and changes patterns among patients receiving treatment for OUD.
Cannabis is the most commonly used illicit drug. In general population, its use has been linked to a heightened propensity for suicidal behavior (SB). We hypothesize that this association varies in patients with psychiatric disorders. SB known vary by sex and therefore an investigation of cannabis' must consider differences. The purpose study investigate between cannabis suicide attempts men women merged data collected two studies based Ontario, Canada (n = 985). employed multivariable...
Background Cannabis is the most commonly used substance among patients in methadone maintenance treatment (MMT) for opioid use disorder. Current programmes neither screen nor manage cannabis use. The recent legalisation of Canada incites consideration into how this may affect current crisis. Aims Investigate health status users MMT. Method Patients were recruited from addiction clinics Ontario, Canada. Regression analyses to assess association between adverse conditions and Further sex...
We provide up-to-date perspectives on the benefits and risks of medical cannabis for pain management in children youth. To date, only two studies (a case report a small observational study) have examined effects No controlled trial has commented long-term safety cannabis. Findings from recreational literature reveal significant potential short- regular use, including impaired driving, depression, suicidality, psychosis, tolerance. Despite this, many youth are self-medicating with cannabis,...
Background: Suicide is a serious public health concern for which there have been well-established protective and risk factors reported in literature. There lack of evidence on the indirect effects other variables these factors. Specifically, association between stressful life events suicidal behavior may be affected by perceived social support, but its role this largely uninvestigated. Objectives: Thus, paper aims to explore support behavior. Perceived will explored as mediator moderator...
Abstract Background As the legalization of recreational cannabis becomes more widespread, its impact on individuals with substance use disorders must be studied. Amidst an ongoing opioid crisis, Canada’s in October 2018 provides important setting for investigation. We examined changes to patterns patients receiving medication-assisted treatment (MAT) disorder (OUD) following legalization. Methods This study includes cross-sectional data from 602 participants recruited 6 months...