A5051470367- Multiple Sclerosis Research Studies
- Erythrocyte Function and Pathophysiology
- Muscle Physiology and Disorders
- Cytokine Signaling Pathways and Interactions
- Pancreatic function and diabetes
- Biochemical and Molecular Research
- Autoimmune Neurological Disorders and Treatments
- Eosinophilic Disorders and Syndromes
- T-cell and B-cell Immunology
- Blood groups and transfusion
- Genetic Neurodegenerative Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- CNS Lymphoma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Inflammatory Myopathies and Dermatomyositis
Heinrich Heine University Düsseldorf
2023-2025
Düsseldorf University Hospital
2025
University of Münster
2024
University at Buffalo, State University of New York
1980
Introduction: The efficacy of anti-CD20 antibodies has significantly contributed to advancing our understanding disease pathogenesis and improved treatment outcomes in relapsing-remitting multiple sclerosis (RRMS). A comprehensive analysis the peripheral immune cell profile, combined with prospective clinical characterization, RRMS patients treated ocrelizumab (OCR) or ofatumumab (OFA) was performed further understand reconstitution following B-cell depletion. Methods: REBELLION-MS is a...
Abstract Background Immune dysregulation is a hallmark of autoimmune diseases the central nervous system (CNS), characterized by an excessive immune response, and primary CNS tumors (pCNS-tumors) showing highly immunosuppressive parenchymal microenvironment. Methods Aiming to provide novel insights into pathogenesis autoimmunity cerebral tumor immunity, we analyzed peripheral blood (PB) cerebrospinal fluid (CSF) 81 limbic encephalitis (ALE), 148 relapsing–remitting multiple sclerosis (RRMS),...
Cells coated with complement components (C3b‐C4b and C4b cells) were prepared by various methods stored in liquid nitrogen using a low‐glycerol, rapid freeze technique. Freshly cells, cells then frozen tested versus antiglobulin anticomplement reagents to evaluate the reactivity of such frozen, stored, complement‐coated human red blood cells. Liquid preservation proved be feasible when compared freshly control
Experimental autoimmune encephalomyelitis (EAE) is the most common murine model for multiple sclerosis (MS) and frequently used to further elucidate still unknown etiology of MS in order develop new treatment strategies. The myelin oligodendrocyte glycoprotein peptide 35-55 (MOG35-55) EAE reproduces a self-limiting monophasic disease course with ascending paralysis within 10 days after immunization. mice are examined daily using clinical scoring system. driven by different pathomechanisms...
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