A5084135830- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Polyomavirus and related diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Immunotherapy and Immune Responses
- Autoimmune Neurological Disorders and Treatments
- Immune Cell Function and Interaction
- Systemic Sclerosis and Related Diseases
- T-cell and B-cell Immunology
- SARS-CoV-2 and COVID-19 Research
- Atherosclerosis and Cardiovascular Diseases
- RNA Interference and Gene Delivery
- Immune Response and Inflammation
- Chronic Lymphocytic Leukemia Research
- Otitis Media and Relapsing Polychondritis
- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Long-Term Effects of COVID-19
- Cytomegalovirus and herpesvirus research
- Dysphagia Assessment and Management
- Autoimmune and Inflammatory Disorders Research
- Neurogenesis and neuroplasticity mechanisms
- Ion channel regulation and function
- Inflammatory Myopathies and Dermatomyositis
- Calcium signaling and nucleotide metabolism
Heinrich Heine University Düsseldorf
2021-2024
Düsseldorf University Hospital
2021-2024
University of Münster
2020-2023
Essen University Hospital
2021-2023
University of Giessen
2023
The University of Sydney
2021-2023
Palacký University Olomouc
2023
Medical University of Vienna
2023
University Hospital of Basel
2023
University of Basel
2023
To evaluate the clinical consequences of extended interval dosing (EID) ocrelizumab in relapsing-remitting multiple sclerosis (RRMS) during coronavirus disease 2019 (COVID-19) pandemic.In our retrospective, multicenter cohort study, we compared patients with RRMS on EID (defined as ≥4-week delay dose interval) a control group standard (SID) at same period (January to December 2020).Three hundred eighteen were longitudinally evaluated 5 German centers. One sixteen received (median...
Background: Oral cladribine has been approved for the treatment of relapsing multiple sclerosis (MS) yet real-world evidence regarding its effectiveness and safety remains scarce. Objective: To evaluate efficacy outcomes MS patients following induction cladribine. Methods: We evaluated our prospective cohort cladribine-treated from two tertiary centres in Germany. Relapses, disability worsening occurrence new or enlarging T2-hyperintense magnetic resonance imaging (MRI) lesions were assessed...
Abstract Although CSF analysis routinely enables the diagnosis of neurological diseases, it is mainly used for gross distinction between infectious, autoimmune inflammatory, and degenerative disorders CNS. To investigate, whether a multi-dimensional cellular blood characterization can support clinically similar we analysed 546 patients with neuroinflammatory, degenerative, or vascular conditions in cross-sectional retrospective study. By combining feature selection dimensionality reduction...
Background Vaccination has proven to be effective in preventing SARS-CoV-2 transmission and severe disease courses. However, immunocompromised patients have not been included clinical trials real-world data point an attenuated immune response vaccines among with multiple sclerosis (MS) receiving immunomodulatory therapies. Methods We performed a retrospective study including 59 ocrelizumab (OCR)-treated MS who received vaccination. Anti-SARS-CoV-2-antibody titres, routine blood parameters...
To provide first real-world experience on patients with MS treated the B cell-depleting antibody ocrelizumab.We retrospectively collected data of who had received at least 1 treatment cycle (2 infusions) ocrelizumab 3 large neurology centers. Patients' characteristics including premedication, clinical disease course, and documented side effects were analyzed.We could identify 210 (125 women, mean age ± SD, 42.1 11.4 years) a duration 7.3 years median Expanded Disability Status Scale score...
In MS, an age-related decline in disease activity and a decreased efficacy of disease-modifying treatment have been linked to immunosenescence, state cellular dysfunction associated with chronic inflammation.To evaluate immunologic alterations we compared immune signatures peripheral blood (PB) CSF by flow cytometry patients relapsing-remitting (RR) (PB n = 38; 51) primary progressive (PP) MS 40; 36) respective controls 85).Analysis revealed significant changes cell composition, especially...
Flow stagnation of peri-ischemic capillaries due to dynamic leukocyte stalls has been described be a contributor ongoing penumbral injury in transient brain ischemia, but not investigated permanent experimental stroke so far. Moreover, it is discussed that obstructing neutrophils are involved this process; however, their contribution yet proven. Here, we characterize the dynamics neutrophil granulocytes two models (photothrombosis and middle cerebral artery occlusion) using intravital...
Abstract Several studies suggest a role for the peripheral immune system in pathophysiology of amyotrophic lateral sclerosis. However, comprehensive investigating intrathecal sclerosis are rare. To elucidate whether compartment-specific inflammation contributes to pathophysiology, we here investigated and profiles patients compared them with controls free neurological disorders (controls) dementia or primary progressive multiple Routine CSF parameters were examined 308 patients, including...
Progressive multifocal leukoencephalopathy (PML) is a rare pathologic CNS condition caused by JC polyomavirus (JCPyV) in immunodeficient patients. Immune checkpoint inhibition was previously reported to potentially facilitate the antiviral response.1
Objectives Alemtuzumab is effective in patients with active multiple sclerosis but has a complex safety profile, including the development of secondary autoimmunity. Most enrolled randomised clinical trials alemtuzumab were either treatment naïve or pretreated injectable substances. Other previous disease-modifying treatments (DMTs) not used study cohorts, and therefore, associated risks might yet remain unidentified. Methods We retrospectively evaluated prospective dual-centre cohort 170...
Autoimmune limbic encephalitis (ALE) presents with new-onset mesial temporal lobe seizures, progressive memory disturbance, and other behavioral cognitive changes. CD8 T cells are considered to play a key role in those cases where autoantibodies (ABs) target intracellular antigens or no ABs were found. Assessment of such patients clinical challenge, novel noninvasive imaging biomarkers urgently needed. Here, we demonstrate that visualization the translocator protein (TSPO) [
Cladribine is a synthetic deoxyadenosine analogue approved for the treatment of highly active relapsing multiple sclerosis (RMS). considered to be semi-selective immune-reconstitution therapy (IRT) that induces long-term remission following short course treatment. Here, we evaluated effect cladribine on immune cell reduction and reconstitution during first two years treatment.We analyzed our longitudinal, prospective, real-world cohort 80 cladribine-treated RMS patients from tertiary centers...
Intravenous methylprednisolone is the standard treatment for a multiple sclerosis relapse; however, this fails to improve symptoms in up one quarter of patients. Immunoadsorption an accepted refractory relapses, but prospective comparator-controlled studies are missing.In observational study, patients with steroid-refractory acute relapses receiving either six courses tryptophan-immunoadsorption or double-dose therapy were analysed. Outcomes evaluated at discharge and three months later....
To report 77 patients with multiple sclerosis (MS) who developed skin-related adverse events (AEs) following treatment cladribine.We evaluated our prospective bicentric cladribine cohort. Cladribine-treated a skin AE were identified.Two hundred thirty-nine cladribine-treated MS evaluated. Seventy-seven (32%) showed at least 1 median month after initiation (range: 1-12). Within first 3 months last exposition, hair thinning (n = 28, 12%), rash 20; 8%), mucositis 13, 5%), and pruritus 6, 3%)...
Abstract It remains largely unclear how thymocytes translate relative differences in T cell receptor (TCR) signal strength into distinct developmental programs that drive the fate decisions towards conventional (Tconv) or regulatory cells (Treg). Following TCR activation, intracellular calcium (Ca 2+ ) is most important second messenger, for which potassium channel K 2P 18.1 a relevant regulator. Here, we identify as central translator of thymus-derived Treg (tTreg) selection process. was...
Neurological manifestations of autoimmune connective tissue diseases (CTD) are poorly understood and difficult to diagnose. We here aimed address this shortcoming by studying immune cell compositions in CTD patients with without neurological manifestation.Using flow cytometry, we retrospectively investigated paired cerebrospinal fluid (CSF) blood samples 28 manifestation, 38 manifestation (N-CTD), non-inflammatory controls, multiple sclerosis (MS) patients, a paradigmatic primary...
Therapeutic options targeting inflammation in multiple sclerosis (MS) have evolved rapidly for relapsing-remitting MS, whereas few therapies are available progressive forms of particular secondary MS (SPMS). The approval siponimod SPMS has allowed optimism the otherwise discouraging therapeutic landscape.We conducted a retrospective, multicenter, non-interventional study analyzing efficacy and safety under real-world conditions 227 patients. According to retrospective framework, data was...
Background Typically defined as a thromboinflammatory disease, ischemic stroke features early and delayed inflammatory responses, which determine the extent of ischemia-related brain damage. T natural killer cells have been implicated in neuronal cytotoxicity inflammation, but precise mechanisms immune cell-mediated progression remain poorly understood. The activating immunoreceptor NKG2D is expressed on both may be critically involved. Methods Results An anti-NKG2D blocking antibody...
To identify radiological and laboratory hallmarks in patients with primary Sjögren's syndrome (pSS) presenting spinal cord involvement.Clinical routine parameters were analyzed a retrospective multicenter case series of four who developed myelitis associated pSS. Serological cerebrospinal fluid (CSF) measurements pSS anti-SSA(Ro)-antibodies initiated, CSF neurofilament light chain (NFL) levels assessed. NFL values compared results from 15 sex- age-matched healthy controls. Radiological...
Rag1-/- mice, lacking functional B and T cells, have been extensively used as an adoptive transfer model to evaluate neuroinflammation in stroke research. However, it remains unknown whether natural killer (NK) cell development functions are altered mice well. This connection has rarely discussed previous studies but might important implications for data interpretation. In contrast, the NOD-Rag1nullIL2rgnull (NRG) mouse is devoid of NK cells therefore eliminate this potential shortcoming....