A5085458889- Salivary Gland Disorders and Functions
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Salivary Gland Tumors Diagnosis and Treatment
- Botulinum Toxin and Related Neurological Disorders
- Rheumatoid Arthritis Research and Therapies
- Telemedicine and Telehealth Implementation
- Systemic Sclerosis and Related Diseases
- Helicobacter pylori-related gastroenterology studies
- Urticaria and Related Conditions
- COVID-19 Clinical Research Studies
- IgG4-Related and Inflammatory Diseases
- SARS-CoV-2 detection and testing
- Inflammatory Myopathies and Dermatomyositis
- Eosinophilic Disorders and Syndromes
- Long-Term Effects of COVID-19
- Gastrointestinal disorders and treatments
- Gastroesophageal reflux and treatments
- Immunodeficiency and Autoimmune Disorders
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- SARS-CoV-2 and COVID-19 Research
- Melanoma and MAPK Pathways
- Spondyloarthritis Studies and Treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- Multiple Sclerosis Research Studies
Medizinische Hochschule Hannover
2016-2024
German Center for Infection Research
2018
University of Lübeck
2018
Immungenetics (Germany)
2015
Objective: Sjögren's syndrome is a heterogeneous inflammatory disorder frequently involving peripheral nerves with wide spectrum of sensory modalities and distribution patterns. The objective this cross-sectional study was to determine characteristics as cause for severe neuropathy limb weakness. Methods: One hundred eighty four patients polyneuropathy associated weakness underwent routine diagnostics including investigations syndrome. Forty-four (ACR-EULAR classification criteria) were...
Interstitial lung disease (ILD) represents a frequent extra-glandular manifestation of primary Sjögren's Syndrome (pSS). Limited published data regarding phenotyping and treatment exists. Advances in managing specific ILD phenotypes have not been comprehensively explored patients with coexisting pSS. This retrospective study aimed to phenotype diseases occurring well-described pSS-ILD cohort describe course outcomes. Between April 2018 February 2020, all pSS attending our Outpatient clinic...
Serology testing is explored for epidemiological research and to inform individuals after suspected infection. During the coronavirus disease 2019 (COVID-19) pandemic, frontline healthcare professionals (HCP) may be at particular risk No longitudinal data on functional seroconversion in HCP regions with low COVID-19 prevalence pre-test probability exist. In a large German university hospital, we performed weekly questionnaire assessments anti-severe acute respiratory syndrome 2 (SARS-CoV-2)...
Early diagnosis and treatment of inflammatory rheumatic diseases can prevent consequential damage such as permanently limited mobility joint or organ damage. Simultaneously, there is an increasing deficit in medical care owing to the lack rheumatological capacity. Rural regions are particularly affected.
Systemic sclerosis (SSc) is a severe rheumatic disease causing fibrotic tissue rearrangement. Aberrant toll-like receptor (TLR) 8 transcripts in plasmacytoid dendritic cells (pDCs) were recently linked to SSc pathogenesis, which at least partially mediated by increased type I interferon (IFN-I) responses. Here, we addressed the functional role of TLR8 signaling different immune cell subsets patients with SSc.
Abstract Melanoma differentiation-associated protein 5 (MDA5) antibody positive amyopathic dermatomyositis (DM) is a rare inflammatory disease. So far, there no official treatment guideline in MDA5 dermatomyositis, but early and aggressive immunosuppressive combination can induce stable remission. We retrospectively analyzed cohort of eight patients (male n = 5) that were diagnosed with MDA5-positive DM. Patient data comprised demographics, CT-guided diagnosis pulmonary involvement, function...
Generalized lymphadenopathy is a common cause of concern for both patients and clinicians. Possible etiologies include infections, malignancies autoimmune diseases. Kikuchi Fujimoto disease (KFD) hyperergic condition that presents with fever, can systemic involvement, thus being easily mistaken the above-mentioned entities. We report case previously healthy 18-year-old male who presented selflimiting generalized lymphadenopathy, high fevers, skin vasculitis polyserositis. The lymph-node...
To identify radiological and laboratory hallmarks in patients with primary Sjögren's syndrome (pSS) presenting spinal cord involvement.Clinical routine parameters were analyzed a retrospective multicenter case series of four who developed myelitis associated pSS. Serological cerebrospinal fluid (CSF) measurements pSS anti-SSA(Ro)-antibodies initiated, CSF neurofilament light chain (NFL) levels assessed. NFL values compared results from 15 sex- age-matched healthy controls. Radiological...
Abstract Objective Extraglandular neurological manifestations of Sjögren’s syndrome are increasingly recognized, defining the disease entity Neuro‐Sjögren. Neuropsychological assessment patients with has hitherto been performed on predominantly rheumatological cohorts. These studies revealed a wide variety prevalence rates for cognitive impairment (22–80%), while variable cut‐off criteria detection were applied. Attentional functions have not yet thoroughly investigated in these patients,...
The phenotype of Sjögren's syndrome-associated neuropathy has been better characterized in recent years. However, remains an underdiagnosed entity with only few insights considering the pathomechanisms nerve damage. Nerve ultrasound proven to be a useful and efficient tool detecting damage autoimmune origin. We, therefore, aimed evaluate this method for neuropathy.Patients syndrome clinical signs underwent sonographic examination both median ulnar nerves. thickening was classified...
Sjögren's syndrome is an immunologically mediated disease with salivary and lacrimal gland destruction characterised by typical sicca symptoms of dry mouth eyes. Awareness extraglandular neurological manifestations such as polyneuropathy affection cranial nerves rising. Hearing loss consequence involvement the vestibulocochlear nerve presents a severe disability. The exact prevalence nature hearing dysfunction in patients Neuro-Sjögren has been insufficiently evaluated to date.
Besides adaptive immunity genes, genetic risk factors for psoriatic arthritis (PsA) include innate loci, which suggests an autoinflammatory disease mechanism, at least in a subset of patients. Here, we aimed investigating the background PsA. A total 120 patients with PsA visiting outpatient clinics Hannover University hospital underwent targeted next-generation sequencing, searching variations genes linked inborn errors classified as disorders (AIDs). Deleteriousness rare variants was...
Tuberculosis (TB) control is a primary global health priority but the goal to eliminate TB being threatened by increase in incidence of multidrug-resistant tuberculosis (MDR-TB). With this series seven MDR-TB cases migrant patients with identical Mycobacterium strains we aim illustrate challenges encountered during therapy and follow-up: language barriers, access care for patients, depression due isolation, adverse reactions treatment, management pediatric TB, further contact tracing. We...
Abstract Background Serology testing is explored for epidemiological research and to inform individuals after suspected infection. During the COVID-19 pandemic, frontline healthcare professionals (HCP) may be at particular risk No longitudinal data on functional seroconversion in HCP regions with low prevalence pre-test probability exist. Methods In a large German university hospital, we performed weekly questionnaire assessments anti-SARS-CoV-2 IgG measurements various commercial tests,...
Telemedicine was implemented in outpatient care during the lockdown between March and May 2020. The aim of study to assess patients from a private practice university department with respect patient satisfaction telemedicine, COVID-19 worries vaccination behavior compare teleconsultation by medical assistant for rheumatology (RFA) physician.Patients rheumatoid arthritis, psoriatric arthropathy or spondylarthritis without treatment modifications since previous presentation were offered...
Diagnosing multiple sclerosis (MS) is challenging due to diverse symptoms and the absence of specific biomarkers. Concurrent autoimmune diseases (AID) or non-specific antibodies further complicate diagnosis, progression monitoring, management. Data on AID prevalence in MS patients are sparse. This study aims identify concurrent AIDs alongside MS.
Treatment options for rheumatoid arthritis (RA), spondyloarthritis (SpA) and psoriatic (PsA) have improved with the introduction of biologic targeted synthetic disease-modifying antirheumatic drugs.Although a good clinical response even remission can be achieved in most cases, low quality life (QOL), depression, chronic pain often persist lead to an increased disease burden.Surveys shown that estimated rates pet owners last decades Germany.In 2019, there was at least 1 dog approximately 19%...