A5013888575- Voice and Speech Disorders
- Respiratory and Cough-Related Research
- Dysphagia Assessment and Management
- Pediatric health and respiratory diseases
- Tracheal and airway disorders
- Gastroesophageal reflux and treatments
- Biochemical Analysis and Sensing Techniques
- Infant Health and Development
- Advanced Chemical Sensor Technologies
- Asthma and respiratory diseases
- Olfactory and Sensory Function Studies
- Speech Recognition and Synthesis
- Phonetics and Phonology Research
- Diverse Musicological Studies
- Gut microbiota and health
- Stuttering Research and Treatment
- Eosinophilic Esophagitis
- Advanced biosensing and bioanalysis techniques
- Biomedical Text Mining and Ontologies
- Immune Response and Inflammation
- Neuroscience of respiration and sleep
- Wound Healing and Treatments
- Cleft Lip and Palate Research
- DNA and Nucleic Acid Chemistry
- Head and Neck Cancer Studies
University of Colorado Anschutz Medical Campus
2016-2025
Google (United States)
2012-2024
Emory University
2021
University of Montana
2021
University of Utah
2021
University of Colorado Denver
2016-2020
Rocky Mountain MS Center
2019
University of Wisconsin–Madison
2010-2017
University of Colorado System
2016
Highland Community College - Illinois
2014
This study investigated the relationship between acoustic spectral/cepstral measures and listener severity ratings in normal disordered voice samples. CAPE-V sentence samples vowel /ɑ/were elicited from eight speakers 24 patients with varying degrees of dysphonia severity. Samples were analysed for cepstral peak prominence (CPP), ratio low-to-high spectral energy, their respective standard deviations. Perceptual overall also obtained all Results showed that variables combined a four-factor...
Abstract Purpose The purpose of this study was to investigate the typical symptoms and medical management characteristics adult patients with refractory chronic cough (RCC) who are referred speech-language pathology (SLP) for behavioral suppression therapy (BCST) in order estimate cost-effectiveness efficiency current practice patterns population. Methods One hundred sixty-four (164) RCC BCST were surveyed. Patients completed an initial survey at onset related symptom pattern prior...
Abstract Prolonged diffuse laryngeal inflammation from smoking and/or reflux is commonly diagnosed as chronic laryngitis and treated empirically with expensive drugs that have not proven effective. Shifts in microbiota been associated many inflammatory diseases, though little known about how resident microbes may contribute to laryngitis. We sought characterize the core of disease-free human tissue investigate shifts microbial community membership exposure cigarette smoke reflux. Using 454...
Background: The term ‘laryngopharyngeal reflux’ (‘LPR’) is frequently applied to aerodigestive symptoms despite lack of objective reflux evidence. This initiative aimed develop a modern care paradigm for LPR supported by otolaryngology and gastroenterology disciplines. Methods: A 28-member international inter-disciplinary working group developed practical statements within the following domains: definition/terminology, initial diagnostic evaluation, monitoring, therapeutic trials, behavioral...
Abstract Objectives/Hypothesis: In vitro modeling of cell‐matrix interactions that occur during human vocal fold scarring is uncommon, as primary scar fibroblast cell lines are difficult to acquire. The purpose this study was characterize morphologic features, growth kinetics, contractile properties, α‐smooth muscle actin (α‐SMA) protein expression and gene profile fibroblasts derived from (sVFF) relative normal (nVFF). Study Design: vitro. Methods: We successfully cultured tissue explants...
Objectives/Hypothesis Vocal fold fibroblasts (VFF) are responsible for extracellular matrix synthesis supporting lamina propria in normal and diseased conditions. When tissue is injured, VFF become activated differentiate into myofibroblasts to facilitate wound healing response. We investigated if vocal can be utilized as surrogate cells scarred VFF. Study Design In vitro. Methods Normal cell lines from a 21‐year‐old male (N21), 59‐year‐old female (N59), scar line 56‐year‐old (S56) were used...
Background Antagonists to the P2X purinergic receptors on airway sensory nerves relieve refractory or unexplained chronic cough (RCC/UCC) but can evoke unwanted dysgeusias because gustatory innervating taste buds express this same family of receptors. However, subunit composition in these systems may differ, with implications for pharmacological intervention RCC/UCC. In most species, extrapulmonary involved predominantly P2X3 subunits that form homotrimeric contrast, mice both P2X2 and...
Although probable causative agents have been identified (e.g., refluxate components, tobacco smoke), the definitive mechanism for inflammation-related laryngeal mucosal damage remains elusive. Multichannel intraluminal impedance combined with pH monitoring (MII/pH) has emerged as a sensitive tool diagnosis and characterization of gastroesophageal reflux disease laryngopharyngeal manifestations. To determine relationship between signs MII/pH, we examined correlations Reflux Finding Score...
Benign vocal fold lesions, including cysts, nodules, polyps, and Reinke's edema, are common causes of hoarseness subsequent voice disorders. Given the prevalence these disease etiology pathophysiology remain unclear their microbiota has not been studied to date secondary paucity available biopsies for investigation. We sought characterize compare bacterial communities in edema collected from patients Germany Wisconsin. These samples were then compared found healthy saliva throat Human...
The primary self-assessment questionnaire used for patients with chronic cough is the Leicester Cough Questionnaire (LCQ). LCQ a validated that ranges in total score from 3 to 21. While it known higher on reflects better quality of life, normative data have not been reported this questionnaire.The purpose study was determine scores healthy population without cough.The distributed via electronic survey authors' universities, professional affiliation email lists, and personal contacts....
Objectives The goal of this preliminary study was to determine whether neck surface electromyography (sEMG) is sensitive possible changes in vocal hyperfunction associated with injection laryngoplasty, particularly respect alterations the degree hyperfunction. Methods Thirteen individuals undergoing office-based laryngoplasty for glottal phonatory insufficiency were prospectively studied a battery acoustic, aerodynamic, endoscopic, and anterior sEMG assessments before procedure approximately...
Objectives/Hypothesis Patients with muscle tension dysphonia often demonstrate an elevation in Reflux Symptom Index (RSI) and 10‐item Voice Handicap (VHI‐10) scores, may be erroneously diagnosed laryngopharyngeal reflux disease. In this study we assessed the effects of voice therapy on RSI VHI‐10 scores patients complaints not responsive to antireflux medications. Study Design Retrospective cohort study. Methods A was conducted at a single tertiary‐care center over 1 year (January...
Objectives/Hypothesis The larynx is a highly responsive organ exposed to mechanical, thermal, and chemical stimuli. Chemicals elicit responses both in intraepithelial nerve fibers specialized chemosensory cells, including scattered solitary cells as well taste organized into buds. Activation of buds the cough, swallow, or apnea with exposure sour bitter substances, even by water sweet‐tasting chemicals. In an effort begin understanding their function, we sought compare distribution, density,...
Misconceptions on Behavioral Cough Suppression Therapy for Pediatric Nonspecific Cough: A Response to Weinberger and Buettner's Commentary Fujiki et al.Laurie Slovarp, PhD, School of Speech, Language, Hearing, & Occupational Sciences, University MontanaMarie Jette, Department Otolaryngology – Head Neck Surgery, Colorado Anschutz Medical CampusJane Reynolds, MontanaAmanda Gillespie, Emory UniversityJulie Barkmeier-Kraemer, Division UtahMary Sandage, Hearing Auburn UniversityJaclyn Smith,...
The larynx is a mucosal organ rich in lymphatic tissue that regularly exposed to multitude of inhaled, ingested, and refluxed microorganisms irritants. first line immune defense the barrier, including resident cells. T regulatory (Treg) cells are specialized subset CD4+ suppress or dampen responses prevent damaging immunopathology. As Treg have been shown preferentially accumulate at sites infection, may contribute persistence infection by impairing antibacterial immunity, we sought quantify...
CO2 laser medial transverse cordotomy is a permanent static procedure performed to achieve adequate functional airway in cases of posterior glottic stenosis and bilateral vocal fold paralysis. Although it the preferred method manage long-term immobility, widely believed that has potential cause aspiration. The minimal existing data on effect surgical enlargement swallowing function heterogeneous. Through investigation dysphagia after cordotomy, we hope better understand influence its role...
Shifts in healthy human microbial communities have now been linked to disease numerous body sites. Noninvasive swabbing remains the sampling technique of choice most locations; however, it is not well known if this method samples entire community, or only those members that are easily removed from surface. We sought compare found via and biopsied tissue true vocal folds, a location difficult sample without causing potential damage impairment function. A secondary aim study was determine swab...