A5091669396- Heavy Metal Exposure and Toxicity
- Immunotoxicology and immune responses
- Pediatric health and respiratory diseases
- Gut microbiota and health
- Trace Elements in Health
- Wound Healing and Treatments
- Animal Ecology and Behavior Studies
- Clostridium difficile and Clostridium perfringens research
- Contact Dermatitis and Allergies
- Essential Oils and Antimicrobial Activity
- Nanoparticles: synthesis and applications
- Therapeutic Uses of Natural Elements
- Zoonotic diseases and public health
- Natural Antidiabetic Agents Studies
- Animal testing and alternatives
- Air Quality and Health Impacts
- Yersinia bacterium, plague, ectoparasites research
- Immune Response and Inflammation
- IL-33, ST2, and ILC Pathways
- Fungal Biology and Applications
- Listeria monocytogenes in Food Safety
- Retinoids in leukemia and cellular processes
- Pressure Ulcer Prevention and Management
- Pesticide Exposure and Toxicity
- Psoriasis: Treatment and Pathogenesis
University of Belgrade
2017-2025
Background: This study explores wound healing and the antimicrobial potential of a natural formulation containing polysaccharide extract from Cerioporus squamosus, hyaluronic acid, dexpanthenol. Methods: Wound effects were assessed using HaCaT keratinocytes, while activity was evaluated against human skin pathogens microdilution assay. In vitro cytotoxicity tests ensured safety, whereas in vivo further investigated an animal model. Gene expression analysis performed to assess molecular...
Inflammatory/immune cells and mediators are substantial for wound healing because they orchestrate biological activities in this complex process. Among factors that affect healing, obesity, metabolic diseases among the most significant, particularly of a relationship between obesity prediabetic state with immune reactivity. Using Dark Agouti (DA) Albino Oxford (AO) rats, which differ responses as well proneness to we examined impact these intrinsic on cutaneous healing. Dynamics process were...
Although obesity and metabolic syndrome (comprising at least three of the following traits—abdominal obesity, elevated blood pressure, triglycerides glucose/insulin resistance, reduced high-density lipoprotein cholesterol in serum) are known to impact immune system activity, these conditions often not considered when response characteristics investigated various rodent strains. In this work, indices compared 3 month-old (young) 6 (adult) rats Dark Agouti (DA) Albino Oxford (AO) strains,...
While the effect of gut microbiota and/or inflammation on a distant body site, including lungs (gut-lung axis), has been well characterized, data about influence lung and homeostasis (lung-gut axis) are scarce. Using well-characterized model pulmonary infection with fungus Aspergillus fumigatus, we investigated alterations in by next-generation sequencing V3-V4 regions total bacterial DNA. Pulmonary due to A. fumigatus caused dysbiosis both gut, but different characteristics. increased alpha...
The aim of this work is in situ anodization/anaphoretic deposition a nano amorphous calcium phosphate (ACP)/chitosan oligosaccharide lactate (ChOL) multifunctional hybrid coating decorated with selenium (Se) on titanium substrate and vivo investigation its immunomodulatory anti-inflammatory effect. Investigating phenomena at the implant-tissue interface interest for controlled inflammation immunomodulation was also research. In our earlier research, we designed coatings based ACP ChOL...
The efficacy of topical dinitrochlorobenzene (DNCB) in the treatment some skin dermatoses is based both on local and systemic effects. It not known, however, whether it can be applied to patients receiving other therapy associated with immunomodulation. aim present paper using a rat model was examine oral warfarin (WF) intake, as shown by others us, had an immunomodulatory potential interfere effects DNCB immunotherapy.Rats received 3.5 mg/l WF sodium drinking water for 30 days were...
The skin is a direct target of the air pollutant benzo[a]pyrene (BaP). While its carcinogenic qualities are well-studied, immunotoxicity BaP after dermal exposure less understood. This study examines immunomodulatory effects 10-day epicutaneous application, in environmentally/occupationally relevant doses, by analyzing ex vivo immune response (skin explant, epidermal cells and draining lymph node/DLN cell activity), alongside skin's reaction to sensitization with experimental hapten...
Bacterial microbiota of the gastrointestinal tract is known to prevent invasion pathogenic microorganisms and regulate intestinal permeability, digestion, metabolism, immune response. It affects function, homeostasis, disease outcomes in extra-intestinal sites such as lungs. This review summarizes currently available knowledge regarding gut-lung axis. The association bacterial composition and/or dysbiosis gut with asthma, chronic obstructive lung disease, cystic fibrosis, recurrent...