A5036776281- Diabetes and associated disorders
- Immune Cell Function and Interaction
- Phytochemicals and Antioxidant Activities
- Immune Response and Inflammation
- Immune cells in cancer
- Macrophage Migration Inhibitory Factor
- Eosinophilic Esophagitis
- Mesenchymal stem cell research
- Neuroinflammation and Neurodegeneration Mechanisms
- Natural Antidiabetic Agents Studies
- Pancreatic function and diabetes
- IL-33, ST2, and ILC Pathways
- Pomegranate: compositions and health benefits
- Diabetes Management and Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Essential Oils and Antimicrobial Activity
- Diet, Metabolism, and Disease
- Polysaccharides and Plant Cell Walls
- Bioactive Compounds in Plants
- Bioactive natural compounds
- Atherosclerosis and Cardiovascular Diseases
- Melanoma and MAPK Pathways
- Breast Cancer Treatment Studies
- Advanced Cellulose Research Studies
- Gastroesophageal reflux and treatments
University of Belgrade
2017-2025
Oncology Institute of Vojvodina
2022
Institute for Biological Research “Siniša Stanković”
2020
Wound healing of acute full-thickness injuries and chronic non-healing ulcers leads to delayed wound closure, prolonged recovery period hypertrophic scarring, generating a demand for an autologous cell therapy relevant pre-clinical research models healing. In this study, immunocompetent model was employed using syngeneic murine line mesenchymal stem cells cultured from the mouse whisker hair follicle outer root sheath (named moMSCORS). moMSCORS were isolated air-liquid interface method,...
Chokeberry (Aronia melanocarpa) is known for its anti-oxidant, anti-inflammatory and anti-diabetic properties. Since the effects of chokeberry extract on immune response have been only sporadically assessed, our aim was to investigate fruit water in vivo vitro. When administered orally healthy mice, exerted immunomodulatory gut evidenced by altered proportion macrophages, dendritic cells T cells. Importantly, oral consumption resulted blood glucose level increase C57BL/6 mice with...
Alzheimer's disease (AD) is characterized by accumulation of amyloid-β plaques that further promotes microglia-mediated neuroinflammatory responses and inflammation in the brain. Emerging data are revealing relation between gut-associated lymphoid tissue (GALT) cells CNS, as effector primed gut might home to This study aimed determine cell composition GALT 5xFAD mice, an established model for AD. Immune isolated from Peyer's patches (PP) mesenteric lymph nodes (MLN) were stained with surface...
Type 1 diabetes (T1D) is an autoimmune disease in which a strong inflammatory response causes the death of insulin-producing pancreatic β-cells, while inefficient regulatory mechanisms allow that to become chronic. Ethyl pyruvate (EP), stable derivate and certified inhibitor alarmin - high mobility group box (HMGB1), exerts anti-oxidant anti-inflammatory properties animal models rheumatoid arthritis encephalomyelitis. To test its therapeutic potential T1D, EP was administered...
Abstract Macrophage migration inhibitory factor (MIF) is a multifunctional protein that involved in the development of gut-related inflammation. To investigate role MIF function intestinal barrier, we have explored permeability and gut-associated immune response MIF-deficient (MIF-KO) mice. The absence provoked impairment tight adherens epithelial junctions colon through disturbance E-cadherin, zonula occludens-1, occludin claudin-2 expression, which lead to increase barrier permeability. In...
Recent data indicate the link between number and function of T regulatory cells (Treg) in gut immune tissue initiation development autoimmunity associated with type 1 diabetes (T1D). Since 3 innate lymphoid (ILC3) small intestine are essential for maintaining FoxP3+ Treg there no about possible role ILC3 T1D pathogenesis, aim this study was to explore ILC3-Treg during T1D. Mature diabetic NOD mice had lower frequencies IL-2-producing lamina propria (SILP) compared prediabetic mice....
Aryl Hydrocarbon Receptor (AHR) ligands, upon binding, induce distinct gene expression profiles orchestrated by the AHR, leading to a spectrum of pro- or anti-inflammatory effects. In this study, we designed, synthesized and evaluated three indole-containing potential AHR ligands (FluoAHRL: AGT-4, AGT-5 AGT-6). All compounds were shown emit fluorescence in near-infrared. Their agonist activity was first predicted using silico docking studies, then confirmed luciferase reporter cell lines....
Ethyl pyruvate (EP), a stable form of pyruvate, has shown beneficial effects in animal models shock, ischemia/reperfusion injury, and sepsis due to its potent anti-oxidant anti-inflammatory properties. Our recent study demonstrated that EP application prevented the clinical manifestation type 1 diabetes mice by augmenting regulatory T cell (Treg) number function. present shows increases Treg proliferation suppressive function (perforin IL-10 expression) during vitro differentiation from...
Ethyl pyruvate (EP) has profound anti-inflammatory and immunomodulatory properties. Here, its effects were determined on experimental autoimmune myocarditis (EAM) induced in mice by heart-specific myosin-alpha heavy chain peptide immunization. EP was applied intraperitoneally, daily, starting with the Severity of EAM histological assessment immune cell infiltrates into heart. Cells phenotypically characterized flow cytometry. Concentration cytokines culture supernatants sera ELISA. reduced...
Mesenchymal stem cells (MSCs) are known for their immunosuppressive properties. Based on the demonstrated anti-inflammatory effect of mouse MSCs from hair follicles (moMSCORS) in a murine wound closure model, this study evaluates potential preventing type 1 diabetes (T1D) C57BL/6 mice. T1D was induced mice by repeated low doses streptozotocin. moMSCORS were injected intravenously weekly basis. reduced incidence, insulitis stage, and preserved insulin production treated animals. primarily...
Type 1 diabetes (T1D) is an autoimmune disease with a strong chronic inflammatory component. One possible strategy for the treatment of T1D to stimulate regulatory arm immune response, i.e. promote function tolerogenic dendritic cells (tolDC) and T (Treg). Since both cell types have been shown be responsive aryl hydrocarbon receptor (AHR) activation, we used recently characterized member new class fluorescent AHR ligands, AGT-5, modulate streptozotocin-induced in C57BL/6 mice. Prophylactic...
Chokeberry has exhibited cardioprotective, anti-bacterial, immunomodulating and anti-cancer properties. extract (CE) was tested in the model of melanoma induced by B16 cells inoculation C57BL/6 mice. CE treatment that began 7 days before continued through observation period, delayed appearance increased infiltration immune tumor microenvironment (TME). Levels TNF, perforin, granzyme B IL-1β did not differ between CE-treated control animals, but TME mice contained more IFN-γ-producing a...
Chokeberry extract boosts anti-bacterial immune response through the activation of macrophage bactericidal capacity and increased proportions cytotoxic T lymphocytes resulting in faster eradication <italic>Listeria monocytogenes</italic>.
Background and Objectives: Reducing time of treatment during COVID-19 outbreaks has been recommended by the leading Radiation Oncology societies. Still minimizing radiation induced tissue toxicity is one most important issues in breast cancer patients. The study aimed to investigate compliance, clinical dosimetry normal toxicity, cosmetic results between moderated ultra-fractionated regimes for patients pandemic. Materials Methods: This pilot prospective randomized included 60 with early...